Patents by Inventor Paul Eastwood

Paul Eastwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT2A ANTAGONISTS
    Publication number: 20070265309
    Abstract: The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R1 and R2 are as defined herein. The compounds of this invention are selective 5HT2A antagonists, and are therefore, useful in treating a variety of diseases including but not limited to a wide variety of sleep disorders as disclosed and claimed herein.
    Type: Application
    Filed: July 25, 2007
    Publication date: November 15, 2007
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Paul EASTWOOD, Hazel HUNT, David FINK, Helen SMITH, Richard TODD
  • SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP)
    Publication number: 20070032489
    Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: September 26, 2006
    Publication date: February 8, 2007
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Philip Weintraub, Paul Eastwood, Shujaath Mehdi, David Stefany, Kwon Musick, Neil Moorcroft, Sungtaek Lim, John Jiang, Hartmut Rutten, Stefan Peukert, Uwe Schwahn
  • Substituted morphinans and methods of their use
    Publication number: 20060063792
    Abstract: Novel 4,5-? epoxy-morphinan compounds are disclosed. Pharmaceutical compositions containing the 4,5-? epoxy-morphinan compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.
    Type: Application
    Filed: September 15, 2005
    Publication date: March 23, 2006
    Applicant: Adolor Corporation
    Inventors: Roland Dolle, Bertrand Le Bourdonnec, Jonathan Sutton, Paul Eastwood, Ines Warner
  • Chemical compounds
    Publication number: 20050228018
    Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
    Type: Application
    Filed: February 14, 2005
    Publication date: October 13, 2005
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Peter Astles, Paul Eastwood, Olivier Houille, Julian Levell, Heinz Pauls, Mark Czekaj, Guyan Liang, Yong Gong, James Pribish, Kent Neuenschwander
  • Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)
    Publication number: 20050054631
    Abstract: The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 10, 2005
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: John Jiang, Jack Koehl, Shujaath Mehdi, Neil Moorcroft, Kwon Musick, Philip Weintraub, Paul Eastwood