Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A wheelbarrow (10) including a receptacle (12) comprising a tub for carrying a load of material; a wheel assembly facilitating movement of the wheelbarrow; a handle for controlling operation of the wheelbarrow; and a plurality of removable compartments (18, 19) located within the receptacle (12), each for containing a portion of the load of material. The receptacle (12) and each removable compartment (18, 19) are configured to interact with each other so as to, in use, hinder movement of each comportment (18, 19) relative to the receptacle (12).

Abstract: A wheelbarrow (10) including a receptacle (12) comprising a tub for carrying a load of material; a wheel assembly facilitating movement of the wheelbarrow; a handle for controlling operation of the wheelbarrow; and a plurality of removable compartments (18, 19) located within the receptacle (12), each for containing a portion of the load of material. The receptacle (12) and each removable compartment (18, 19) are configured to interact with each other so as to, in use, hinder movement of each comportment (18, 19) relative to the receptacle (12).

Abstract: A detector assembly (10) powered by mains electricity and an elongate backup battery (76) is disclosed. The assembly includes: a ceiling mountable base (10) having a body defining a downwardly opening socket (24); a detector module (20) having a battery support portion (75) for holding the battery (76) in a vertical orientation, the module (20) receivable by the socket (24); a quick connection means for mechanically and electrically connecting the module (20) to the base (10); and shutter (50) mounted to the base (10). The shutter (50) prevents operation of the quick connection means when no vertical battery (76) is installed within the module (20). The quick connection means comprises co-operable pairs of conductors. The conductor pairs transmit power from the base (10) to the module (20). The pairs of conductors each comprise a stud conductor mounted to the base (10) and a forked conductor mounted to the module (20).