Abstract: The invention features compositions and methods for treating inflammation and other immune-related disorders.

Abstract: The apparatus and methods of the present invention provide a non-invasive measurement of blood pressure with a frequency that approximates a continuous measurement. Blood pressure measurement provides information that is both clinically and diagnostically significant. In accordance with an aspect of the present invention, a method for providing a non-invasive measurement of blood pressure, includes obtaining a first input signal and a second input signal indicative of occlusive measurements of systolic blood pressure and diastolic blood pressure, respectively; tracking a signal indicative of pulse pressure; continuously measuring a third signal indicative of mean blood pressure; and processing the signals to obtain a measurement indicative of systolic and diastolic blood pressure, wherein at least a portion of the measurement indicative of systolic and diastolic blood pressure is continuous.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode, The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: Several techniques are provided for aiding in the discrimination of detected biological signals indicative of blood pressure from detected signals not indicative of blood pressure (e.g., noise). A threshold, based predominantly on a level of noise, is developed and used in the discrimination. A second threshold, based predominantly on levels of previously detected biological signals, is developed and additionally used to help discriminate the biological signals from noise. The biological signals are detected during a selected portion of a cardiac cycle, and additional signals detected outside of the selected portion of the cycle are applied to the detected signals. Another threshold may be developed based predominantly on a level of signals sensed by a transducer positioned to preferentially sense noise; the transducer is positioned so that the noise that it detects is related to noise that is detected during the detection of the biological signals.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: A stethoscope, operable in an acoustic or electronically augmented mode, is disclosed. In one electronically augmented mode of operation, the stethoscope simultaneously provides the listener with combined unmodified, familiar audible sounds and sounds which have been electronically augmented to bring them within the human auditory range. Additionally, a timing sound may be provided along with the unmodified, familiar audible sounds and electronically augmented sounds to assist the listener in determining when sounds occur in the heart cycle. The timing sound may be enabled in the acoustic mode of stethoscope operation so that the listener can place familiar audible sounds within the heart cycle.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectivley operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operartion. All fluids flow through a unitary disposable cassette without making any other system contact.

Abstract: Apparatus and method for continuously monitoring the fetal heart rate simultaneously using ultrasonic and electrocardiographic signals. The signals are continuously processed to provide an improved output fetal heart rate indication in terms of better continuity and accuracy.

Abstract: Apparatus and method for continuously monitoring the fetal heart rate simultaneously using ultrasonic and electrocardiographic signals. The signals are continuously processed to provide an improved output fetal heart rate indication in terms of better continuity and accuracy.

Abstract: Apparatus and method for continuously monitoring the fetal heart rate simultaneously using ultrasonic and electrocardiographic signals. The signals are continuously processed to provide an improved output fetal heart rate indication in terms of better continuity and accuracy.

Abstract: An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact.