Patents by Inventor Paul F. Sieving

Paul F. Sieving has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polychelants
    Patent number: 6274713
    Abstract: Invention is directed to polychelants and their metal chelates which are useful in diagnostic imaging. The polychelants comprise a plurality of macrocyclic chelant moieties, eg. DOTA residues, conjugated by thiourea, urea or glycinamide linkages to a backbone moiety through a donor atom.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 14, 2001
    Assignee: Salutar, Inc.
    Inventors: Paul F. Sieving, Alan David Watson, Steven C. Quay, Scott Michael Rocklage
  • Adducts of macrocyclic chelants
    Patent number: 5554748
    Abstract: There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a polyamine backbone molecule, e.g. polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein. For example, adducts of a macrocyclic chelant can be formed by the process of (a) dispersing a carboxylic macrocyclic chelant in a polar, anhydrous solvent, (b) adding a base with a pKa sufficient to remove all carboxyl protons to create an amine salt of the chelant soluble in the solvent, (c) chilling the reaction mixture to between about 5.degree. C. and 55.degree. C.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: September 10, 1996
    Assignee: Nycomed Salutar, Inc.
    Inventors: Paul F. Sieving, Alan D. Watson
  • Polychelants containing macrocyclic chelant moieties
    Patent number: 5364613
    Abstract: There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g, DOTA residues, conjugated to a polyamine backbone molecule, e.g, polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: November 15, 1994
    Inventors: Paul F. Sieving, Alan D. Watson, Steven C. Quay, Scott M. Rocklage