Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.

Abstract: Systems and methods that use interference signal from a sample tissue (e.g. retina) obtained in a self-referenced manner to obtain one or more characteristics about the sample tissue, such as thickness and intensity information, are discussed in the present disclosure. One example method of analyzing the sample tissue using an interferometry system includes illuminating the sample tissue with a beam of light using a spectrally broadband source. Scattered light signal is collected from the sample tissue at a detector. The signal results from optical interference between light scattered from multiple scatterers located at different depths in the tissue. The light signal is dominated by light scattered from a scatterer located within the bulk of the tissue. One or more characteristics of the sample tissue are determined based on the collected signal.

Abstract: Systems and methods for improving the assessment of disruption or abnormalities to retinal layers are presented. The disruptions are detected by analyzing at least one segmented boundary of optical coherence tomography data. Several different types of analysis can be used alone or in combination to make an assessment of the level of disruption to the particular boundary or layer defined by the boundary. The results can be presented as an end face image and quantified to report an amount of disruption. In one embodiment, a method for determining the disruption to the photoreceptor outer segment is described.

Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

Abstract: Systems and methods that use interference signal from a sample tissue (e.g. retina) obtained in a self-referenced manner to obtain one or more characteristics about the sample tissue, such as thickness and intensity information, are discussed in the present disclosure. One example method of analyzing the sample tissue using an interferometry system includes illuminating the sample tissue with a beam of light using a spectrally broadband source. Scattered light signal is collected from the sample tissue at a detector. The signal results from optical interference between light scattered from multiple scatterers located at different depths in the tissue. The light signal is dominated by light scattered from a scatterer located within the bulk of the tissue. One or more characteristics of the sample tissue are determined based on the collected signal.

Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.

Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.

Abstract: The present invention improves projection displays of volume data. Using the Minimum Intensity Projection (MinIP), fluid filled regions or other regions of hyporeflective tissue are displayed. By limiting the projection to partial volumes within the volume, differences in the scattering intensity within specific regions are isolated. In this way, hyperreflectivity of weakly scattering tissue can be assessed.

Abstract: Methods and devices for reducing noise effects in a system for measuring a physiological parameter, including receiving an input signal, obtaining an assessment of the signal quality of the input signal, selecting coefficients for a digital filter using the assessment of signal quality; and filtering the input signal using the digital filter, without comparing the filter's output signal with the input signal.

Abstract: The present invention improves projection displays of volume data. Using the Minimum Intensity Projection (MinIP), fluid filled regions or other regions of hyporeflective tissue are displayed. By limiting the projection to partial volumes within the volume, differences in the scattering intensity within specific regions are isolated. In this way, hyperreflectivity of weakly scattering tissue can be assessed.

Abstract: Methods and devices for reducing noise effects in a system for measuring a physiological parameter, including receiving an input signal, obtaining an assessment of the signal quality of the input signal, selecting coefficients for a digital filter using the assessment of signal quality; and filtering the input signal using the digital filter, without comparing the filter's output signal with the input signal.

Abstract: Systems and methods for efficiently displaying large volumes of medical imaging data using pre-defined dynamic displays to illustrate key anatomic features are described. In a preferred embodiment, one or more pulse files comprising en face images of sub sections of the volume are displayed sequentially to the user in a playback loop. These displays can aid in navigation of data for review and future data acquisition. Additional images generated from the data can be displayed next to or overlaid on the pulse files.

Abstract: The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

Abstract: Embodiments of the present invention provide methods for finding the lateral position of the fovea in an OCT image volume. In one instance, a cost function is developed whose minimum is located at or near the foveal center. This cost function includes one or more measures of retinal layer thickness and/or measures of distance from blood vessels or a priori locations.

Abstract: Various methods are disclosed for mapping optical coherence tomography (OCT) data to facilitate review and diagnosis. In one aspect, high resolution 2D line scans are obtained along with lower density 3D cube scans and displayed in a manner to provide context to the clinician. In another aspect, OCT data is analyzed to provide information about non-uniformities of the tissue. Binary image maps of maps useful for determining tautness of membranes are also disclosed.