Patents by Inventor Paul Fatheree

Paul Fatheree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dual-acting antihypertensive agents
    Patent number: 8349875
    Abstract: The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: January 8, 2013
    Assignee: Theravance, Inc.
    Inventors: Paul Allegretti, Seok-Ki Choi, Roland Gendron, Paul Fatheree, Keith Jendza, Robert Murray McKinnell, Darren McMurtrie, Brooke Olson
  • Dual-acting antihypertensive agents
    Patent number: 8236846
    Abstract: The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: August 7, 2012
    Assignee: Theravance, Inc.
    Inventors: Paul Allegretti, Seok-Ki Choi, Roland Gendron, Paul Fatheree, Keith Jendza, Robert Murray McKinnell, Darren McMurtrie, Brooke Olson
  • INDAZOLE-CARBOXAMIDE COMPOUNDS
    Publication number: 20100292223
    Abstract: The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 23, 2010
    Publication date: November 18, 2010
    Applicant: THERAVANCE, INC.
    Inventors: Paul FATHEREE, Roland GENDRON, Adam A. GOLDBLUM, Daniel D. LONG, Daniel MARQUESS, S. Derek TURNER, Seok-Ki CHOI
  • Indazole-carboxamide compounds
    Patent number: 7786136
    Abstract: The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: August 31, 2010
    Assignee: Theravance, Inc.
    Inventors: Paul Fatheree, Roland Gendron, Adam A Goldblum, Daniel D Long, Daniel Marquess, S. Derek Turner, Seok-Ki Choi
  • 5-HTreceptor agonist compounds
    Patent number: 7534889
    Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: May 19, 2009
    Assignee: Theravance, Inc.
    Inventors: Seok-Ki Choi, Paul Fatheree, Adam A Goldblum, Lan Jiang, Daniel D Long, Daniel Marquess, S. Derek Turner
  • Quinolinone-carboxamide compounds
    Patent number: 7498442
    Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: March 3, 2009
    Assignee: Theravance, Inc.
    Inventors: Seok-Ki Choi, Paul Fatheree, Roland Gendron, Adam A Goldblum, Lan Jiang, Daniel D Long, Daniel Marquess
  • 5-HT4 RECEPTOR AGONIST COMPOUNDS
    Publication number: 20080255187
    Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 11, 2008
    Publication date: October 16, 2008
    Inventors: Seok-Ki Choi, Paul Fatheree, Adam A. Goldblum, Lan Jiang, Daniel D. Long, Daniel Marquess, S. Derek Turner
  • Indazole-carboxamide compounds
    Patent number: 7419989
    Abstract: The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: September 2, 2008
    Assignee: Theravance, Inc.
    Inventors: Paul Fatheree, Roland Gendron, Adam A Goldblum, Daniel D Long, Daniel Marquess, S. Derek Turner, Seok-Ki Choi
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7405199
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: July 29, 2008
    Assignee: Theravance, Inc.
    Inventors: Daniel Marquess, Martin S. Linsell, Paul Fatheree, Michael R. Leadbetter
  • 5-HTreceptor agonist compounds
    Patent number: 7399862
    Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: July 15, 2008
    Assignee: Theravance, Inc.
    Inventors: Seok-Ki Choi, Paul Fatheree, Adam A Goldblum, Lan Jiang, Daniel D Long, Daniel Marquess, S. Derek Turner
  • Quinolinone-carboxamide compounds
    Publication number: 20080167295
    Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: March 13, 2008
    Publication date: July 10, 2008
    Inventors: Seok-Ki Choi, Paul Fatheree, Roland Gendron, Adam A. Goldblum, Lan Jiang, Daniel D. Long, Daniel Marquess
  • Quinolinone-carboxamide compounds
    Patent number: 7396933
    Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: July 8, 2008
    Assignee: Theravance, Inc.
    Inventors: Seok-Ki Choi, Paul Fatheree, Roland Gendron, Adam A Goldblum, Lan Jiang, Daniel D Long, Daniel Marquess
  • Indazole-carboxamide compounds
    Publication number: 20080132491
    Abstract: The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: January 15, 2008
    Publication date: June 5, 2008
    Inventors: Paul Fatheree, Roland Gendron, Adam A. Goldblum, Daniel D. Long, Daniel Marquess, S.Derek Turner, Seok-Ki Choi
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080108558
    Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: October 25, 2007
    Publication date: May 8, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Long, Daniel Marquess, Edmund Moran, Matthew Nodwell, S. Derek Turner, James Aggen
  • Cross-linked glycopeptide - cephalosporin antibiotics
    Publication number: 20080103299
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: December 19, 2007
    Publication date: May 1, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Marquess, Daniel Long, Jason Chinn, Matthew Nodwell, Edmund Moran, James Aggen
  • Glycopeptide derivatives and pharmaceutical compositions containing the same
    Publication number: 20080103292
    Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: October 24, 2007
    Publication date: May 1, 2008
    Inventors: J. Judice, Paul Fatheree, Bernice Lam, Michael Leadbetter, Martin Linsell, YongQi Mu, Sean Trapp, Guang Yang, Yan Zhu
  • Carbamate compounds as 5-HT4 receptor agonists
    Publication number: 20080090811
    Abstract: The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclosure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: December 6, 2007
    Publication date: April 17, 2008
    Inventors: Daniel Long, Seok-Ki Choi, Paul Fatheree, Adam Goldblum, Daniel Marquess
  • Benzoimidazolone-carboxamide compounds as 5-HT4 receptor agonists
    Publication number: 20080070923
    Abstract: The invention provides novel benzoimidazolone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: November 20, 2007
    Publication date: March 20, 2008
    Inventors: Roland Gendron, Seok-ki Choi, Paul Fatheree, Adam Goldblum, Daniel Long, Daniel Marquess, S. Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080051577
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 28, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Marquess, S. Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080045721
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 21, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Long, Daniel Marquess, Edmund Moran, Matthew Nodwell, S. Derek Turner, James Aggen