Patents by Inventor Paul Fiedler

Paul Fiedler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7129056
    Abstract: A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular infection by various viruses or other infectious agents, and also cells which have expressed surface epitopes that indicate the presence of non-infectious medical conditions. The analysis involves the examination of cells in the blood sample for the presence or absence of particular surface epitopes while the blood sample is disposed in a centrifuged blood sampling container. The epitopic analysis for the presence or absence of infected cells, or cells which indicate the presence of non-infectious medical conditions relies on the detection of known target expressed epitopes. The target epitopes on the target cell types are epitopes which are also known to be absent on normal circulating cells in the blood.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: October 31, 2006
    Inventors: David L. Rimm, Paul Fiedler, Robert A. Levine, Stephen C. Wardlaw
  • Publication number: 20050239058
    Abstract: A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular infection by various viruses or other infectious agents, and also cells which have expressed surface epitopes that indicate the presence of non-infectious medical conditions. The analysis involves the examination of cells in the blood sample for the presence or absence of particular surface epitopes while the blood sample is disposed in a centrifuged blood sampling container. The epitopic analysis for the presence or absence of infected cells, or cells which indicate the presence of non-infectious medical conditions relies on the detection of known target expressed epitopes. The target epitopes on the target cell types are epitopes which are also known to be absent on normal circulating cells in the blood.
    Type: Application
    Filed: June 20, 2005
    Publication date: October 27, 2005
    Inventors: David Rimm, Paul Fiedler, Robert Levine, Stephen Wardlaw
  • Patent number: 6911315
    Abstract: A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular infection by various viruses or other infectious agents, and also cells which have expressed surface epitopes that indicate the presence of non-infectious medical conditions. The analysis involves the examination of cells in the blood sample for the presence or absence of particular surface epitopes while the blood sample is disposed in a centrifuged blood sampling container. The epitopic analysis for the presence or absence of infected cells, or cells which indicate the presence of non-infectious medical conditions relies on the detection of known target expressed epitopes. The target epitopes on the target cell types are epitopes which are also known to be absent on normal circulating cells in the blood.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: June 28, 2005
    Inventors: David L. Rimm, Paul Fiedler, Robert A. Levine, Stephen C. Wardlaw
  • Patent number: 6670197
    Abstract: This method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence or absence of fragments of target analyte cancer cells which are circulating in blood. The analysis is performed in a sample of centrifuged anticoagulated whole blood. The analysis of the presence or absence of fragments of cancer cells relies on the detection of external or internal binding sites which are known to be present only in or on tumorous cancer cells. Fluorophors with distinct wavelength emissions are coupled with antibodies, or other binding moieties such as complementary nucleotide sequences, which antibodies are directed against the epithelial cell fragment membrane binding sites, such as internal or external surface epitopes on the cell fragments, or internal binding sites on cell organelles; and which nucleotide sequences are complementary to portions of cell fragment RNA and/or DNA. The labled binding agents are humoric or soluble in the blood sample.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: December 30, 2003
    Inventors: David L. Rimm, Stephen C. Wardlaw, Robert A. Levine, Paul Fiedler
  • Patent number: 6444436
    Abstract: A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence or absence of target cancer cells and/or hematologic progenitor cells, or other rare events which are known to circulate in blood. The analysis is performed in a sample of centrifuged anticoagulated whole blood. The analysis involves both morphometric and epitopic examination of the blood sample while the blood sample is disposed in a centrifuged blood sampling container. The epitopic analysis of the presence or absence of cancer cells relies on the detection of epitopes which are known to be present on cancer cells and not on normal circulating blood cells; and the epitopic analysis of the presence or absence of hematologic progenitor cells relies on the detection of epitopes which are known to be present on hematologic progenitor cells and not on normal circulating blood cells.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: September 3, 2002
    Inventors: David L. Rimm, Paul Fiedler, Robert A. Levine, Stephen C. Wardlaw
  • Publication number: 20020061542
    Abstract: A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence of target cells which have expressed surface epitopes that indicate intracellular infection by various viruses or other infectious agents, and also cells which have expressed surface epitopes that indicate the presence of non-infectious medical conditions. The analysis involves the examination of cells in the blood sample for the presence or absence of particular surface epitopes while the blood sample is disposed in a centrifuged blood sampling container. The epitopic analysis for the presence or absence of infected cells, or cells which indicate the presence of non-infectious medical conditions relies on the detection of known target expressed epitopes. The target epitopes on the target cell types are epitopes which are also known to be absent on normal circulating cells in the blood.
    Type: Application
    Filed: January 10, 2002
    Publication date: May 23, 2002
    Inventors: David L. Rimm, Paul Fiedler, Robert A. Levine, Stephen C. Wardlaw
  • Publication number: 20010024802
    Abstract: This method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence or absence of fragments of target analyte cancer cells which are circulating in blood. The analysis is performed in a sample of centrifuged anticoagulated whole blood. The analysis of the presence or absence of fragments of cancer cells relies on the detection of external or internal binding sites which are known to be present only in or on tumorous cancer cells. Fluorophors with distinct wavelength emissions are coupled with antibodies, or other binding moieties such as complementary nucleotide sequences, which antibodies are directed against the epithelial cell fragment membrane binding sites, such as internal or external surface epitopes on the cell fragments, or internal binding sites on cell organelles; and which nucleotide sequences are complementary to portions of cell fragment RNA and/or DNA. The labled binding agents are humoric or soluble in the blood sample.
    Type: Application
    Filed: March 5, 2001
    Publication date: September 27, 2001
    Inventors: David L. Rimm, Stephen C. Wardlaw, Robert A. Levine, Paul Fiedler
  • Patent number: 6197523
    Abstract: A method for analyzing blood enables one to isolate, detect, enumerate and confirm under magnification the presence or absence of target cancer cells and/or hematologic progenitor cells which are known to circulate in blood. The analysis is performed in a sample of centrifuged anticoagulated whole blood. The analysis involves both morphometric and epitopic examination of the blood sample while the blood sample is disposed in a centrifuged blood sampling tube. The epitopic analysis of the presence or absence of cancer cells relies on the detection of epitopes which are known to present only on cancer cells; and the epitopic analysis of the presence or absence of hematologic progenitor cells relies on the detection of epitopes which are known to present only on hematologic progenitor cells.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: March 6, 2001
    Inventors: David L. Rimm, Robert A. Levine, Stephen C. Wardlaw, Paul Fiedler
  • Patent number: 5496704
    Abstract: A biological sample such as feces, sputum, cervical tissue, pleural fluids, exudates, cytologic specimens, or the like, is tested for the presence or absence of: ova; parasites; microorganisms; inflammatory, neoplastic tissue cells; or other target materials which are indicative of infestation, disease or infection. The sample is mixed with a buffer fluid and placed in a transparent tube which contains a volume-constricting cylindrical insert for gravimetric separation of components of the sample. The mixture is centrifuged, and the annular space between the insert and tube bore is examined under magnification for the presence of the target materials.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: March 5, 1996
    Inventors: Paul Fiedler, Robert A. Levine, Stephen C. Wardlaw
  • Patent number: 4988829
    Abstract: A process for making the known fungicide intermediate 2-(4-chlorophenyl ethyl)-2-tert.-butyloxirane of the formula ##STR1## comprising (a) mixing a solution of trimethylsulphonium bromide of the formula(CH.sub.3).sub.3 S.sup..sym. Br.sup..crclbar. (II)in a methanol/toluene mixture with preheated toluene and simultaneously distilling off a methanol/toluene mixture at a temperature between 65.degree. and 110.degree. C. until a suspension having a solids content between 10 and 70% by weight is formed, and(b) reacting the suspension of trimethylsulphonium bromide in toluene thus obtained with 1-(4-chlorophenyl)-4,4-dimethylpentan-3-one of the formula ##STR2## in the presence of solid potassium hydroxide, diethylene glycol and water at a temperature between 20.degree. and 120.degree. C.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: January 29, 1991
    Assignee: Bayer Aktiengessellschaft
    Inventors: Paul Fiedler, Martin Littmann, Manfred Lenthe, Achim Noak, Gerd Siekmann
  • Patent number: 4978771
    Abstract: The selective hydrogenation of unsaturated compounds which carry reducible groups containing nitrogen succeeds in a homogeneous phase with the preservation of the reducible groups containing nitrogen, characterized in that a compound of the formulaRuH.sub.2n L.sub.5-nis used as a catalyst, in whichL signifies a phosphane or arsane andn signifies 1 or 2.
    Type: Grant
    Filed: May 18, 1988
    Date of Patent: December 18, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Hartmuth Buding, Rudolf Braden
  • Patent number: 4812587
    Abstract: Carbon-carbon double bonds are hydrogenated selectively in a compound containing a reducible, nitrogen-containing group if the hydrogenation is carried out in the presence of a ruthenium complex catalyst. Also disclosed are new ruthenium complexes for use in such selective hydrogenation.
    Type: Grant
    Filed: January 29, 1987
    Date of Patent: March 14, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Rudolf Braden, Hartmuth Buding
  • Patent number: 4795788
    Abstract: Unsaturated polymers containing nitrile groups can be hydrogenated with the preservation of the nitrile group in a homogeneous phase with a catalyst of the formula:RuX[(L.sub.1) (L.sub.2).sub.n ]in whichX represents hydrogen, halogen or SnCl.sub.3,L.sub.1 represents optionally substituted indenyl,L.sub.2 represents a phosphane, bisphosphane or arsane and n signifies 1 or 2,if a low-molecular ketone is used as a solvent.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: January 3, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Himmler, Paul Fiedler, Rudolf Braden, Hartmuth Buding
  • Patent number: 4746707
    Abstract: The selective hydrogenation in a homogeneous phase of unsaturated compounds carrying reducible groups containing nitrogen so as to preserve the reducible groups containing nitrogen succeeds with excellent yields if a compound corresponding to the following general formula:RuH.sub.m (R.sub.1 CO.sub.2).sub.n (L).sub.pwhereinR.sub.1 represents an optionally substituted alkyl, aryl, cycloalkyl or aralkyl group;L represents a phosphane or arsane;m represents 0 or 1;n represents 1 or 2; andp represents 2 or 3;is used as catalyst.
    Type: Grant
    Filed: August 1, 1986
    Date of Patent: May 24, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Hartmuth Buding, Rudolf Braden, Joachim Thormer
  • Patent number: 4673757
    Abstract: Carbon-carbon double bonds are hydrogenated selectively in a compound containing a reducible, nitrogen-containing group if the hydrogenation is carried out in the presence of a ruthenium complex catalyst. Also disclosed are new ruthenium complexes for use in such selective hydrogenation.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: June 16, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Rudolf Braden, Hartmuth Buding
  • Patent number: 4631315
    Abstract: Nitrile group-containing polymers are hydrogenated in a homogeneous phase with preservation of the nitrile groups in a low molecular weight ketone as a solvent and with a compound corresponding to formulaRuX[(L.sub.1)(L.sub.2).sub.n ]as a catalyst, whereinX represents hydrogen, halogenL.sub.1 represents hydrogen, halogen, optionally substituted cyclopentadienyl,L.sub.2 represents a phosphane, bisphosphane or arsane andn is 1, 2 or 3 and[(L.sub.1)(L.sub.2).sub.n ] represents a cyclopentadienyl bisphosphane.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: December 23, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hartmuth Buding, Paul Fiedler, Heinrich Konigshofen, Joachim Thormer
  • Patent number: 4536344
    Abstract: Aryl halides are formylated with carbon monoxide and hydrogen in the presence of a noble metal catalyst, tertiary organic nitrogen compounds and phosphanes or phosphites.
    Type: Grant
    Filed: November 4, 1983
    Date of Patent: August 20, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Rudolf Braden
  • Patent number: 4487966
    Abstract: 3-Aminomethyl-1-(3-aminopropyl-1-methyl)-4-methylcyclohexane and a process for the preparation of this new compound, which uses limonene and/or monohydroformylation products of limonene as starting substances and proceeds via a dihydroformylation product of limonene. The new compound is useful as a corrosion inhibitor, as a crosslinking agent for epoxide resins and as a chain lengthening agent for NCO prepolymers.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: December 11, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Rudolf Braden
  • Patent number: RE34548
    Abstract: The selective hydrogenation of unsaturated compounds which carry reducible groups containing nitrogen succeeds in a homogeneous phase with the preservation of the reducible groups containing nitrogen, characterized in that a compound of the formulaRuH.sub.2n L.sub.5-nis used as a catalyst, in whichL signifies a phosphane or arsane andn signifies 1 or 2.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: February 15, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Fiedler, Hartmuth Buding, Rudolf Braden