Patents by Inventor Paul Fields

Paul Fields has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190285521
    Abstract: Systems and methods for inline and automatic dilution of chemicals of interest for speciation and subsequent analysis by ICP spectrometry are described. A system embodiment includes a first valve to receive a sample into a holding loop; a plurality of syringe pumps coupled to the first valve to deliver an inline diluted sample from the first valve; and a second valve coupled to the first valve to receive the inline diluted sample from the first valve into a sample holding loop coupled to the second valve, the second valve configured to couple to at least one of an eluent source or a carrier fluid source to receive at least one of an eluent fluid or a carrier fluid to transfer the inline diluted sample from the sample holding loop to a speciation column to separate one or more species from the inline diluted sample.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 19, 2019
    Inventors: Michael Paul Field, Daniel R. Wiederin, Patrick Sullivan
  • Publication number: 20190183628
    Abstract: Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature. A blood deflecting assembly can deflect embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicant: Claret Medical, Inc.
    Inventors: Cameron Paul Purcell, Antony J. Fields, Whittaker Ian Hamill, Daniel Wayne Fifer, Philip Jon Haarstad, David John Blaeser
  • Patent number: 10269548
    Abstract: A system embodiment includes, but is not limited to, a syringe pump operably coupled to a desolvation unit, the desolvation unit coupled to a sample analyzer configured to measure an intensity of one or more analytes in a sample solution provided through operation of the syringe pump; and a controller operably coupled to the syringe pump, the controller configured to receive the intensity of the one or more analytes measured by the sample analyzer, determine whether the intensity exceeds a threshold difference of an intensity of at least one standard measured by the sample analyzer, and adjust one or more control parameters of the syringe pump when the intensity of the one or more analytes exceeds the threshold difference to control a flow rate of the sample solution introduced to the sample analyzer.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 23, 2019
    Assignee: Elemental Scientific, Inc.
    Inventor: Michael Paul Field
  • Patent number: 10241013
    Abstract: Systems and methods for inline and automatic dilution of chemicals of interest for speciation and subsequent analysis by ICP spectrometry are described. A system embodiment includes a first valve to receive a sample into a holding loop; a plurality of syringe pumps coupled to the first valve to deliver an inline diluted sample from the first valve; and a second valve coupled to the first valve to receive the inline diluted sample from the first valve into a sample holding loop coupled to the second valve, the second valve configured to couple to at least one of an eluent source or a carrier fluid source to receive at least one of an eluent fluid or a carrier fluid to transfer the inline diluted sample from the sample holding loop to a speciation column to separate one or more species from the inline diluted sample.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: March 26, 2019
    Assignee: ELEMENTAL SCIENTIFIC, INC.
    Inventors: Paul Field, Daniel R. Wiederin, Patrick Sullivan
  • Publication number: 20190072464
    Abstract: Systems and methods are described to concentrate a remote sample for analysis. A sample concentration system embodiment includes, but is not limited to, a plurality of valves including at least a first valve, a second valve, and a third valve; a plurality of columns including at least a first column and a second column, the first column fluidically coupled to the first valve, the second column fluidically coupled to the second valve; and a flow meter coupled with the third valve, the flow meter fluidically coupled with each of the first column and the second column when the plurality of valves is in a first flow path configuration to measure an amount of the liquid sample passed through the first column and the second column, wherein the plurality of valves includes a second flow path configuration and a third flow path configuration.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 7, 2019
    Inventors: Daniel R. Wiederin, Austin Schultz, Michael Paul Field, Nathan Saetveit
  • Patent number: 10018543
    Abstract: A method includes supplying a reagent to a column, where the column is configured to purify an element from a sample matrix for isotopic analysis. The method also includes loading the column with the sample matrix, and supplying a second reagent to collect the element retained by the column. The method further includes loading the column with a second sample mixture, and collecting an element from the second sample mixture retained by the column. A column configured to separate an element from a sample matrix for isotopic analysis includes a resin configured to retain the element. The column also includes a first frit disposed of a first end of the column and a second frit disposed of a second end of the column. The column is configured to receive a first reagent in a first flow direction and a second reagent in a second flow direction different from the first flow direction.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 10, 2018
    Assignee: ELEMENTAL SCIENTIFIC, INC.
    Inventors: Daniel R. Wiederin, Paul Field
  • Patent number: 9953822
    Abstract: A system includes a sample selector device, a chromatographic column selectively connectable to the sample selector device, and a spectrometry analysis device selectively connectable to the sample selector device. The sample selector device is configured to supply multiple individual samples to the chromatographic column to separate components of the individual samples. The sample selector device is also configured to store the separated components of the individual samples. The sample selector device is further configured to supply the separated components of the individual samples to the spectrometry analysis device. In embodiments of the disclosure, the components of the individual samples can be chromatographically separated while the spectrometry analysis device is offline.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: April 24, 2018
    Assignee: Elemental Scientific, Inc.
    Inventors: Daniel R. Wiederin, Paul Field
  • Publication number: 20170231240
    Abstract: A rapid method to detect and/or remove mobile insects inside granular material is presented. The core of this method is to heat grain samples to the desired temperatures (about 55 C) using microwave or radio frequency energy to force insects to move out of the granular material.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 17, 2017
    Inventors: Fuji JIAN, Digvir JAYAS, Paul FIELDS
  • Publication number: 20170162373
    Abstract: Systems and methods for inline and automatic dilution of chemicals of interest for speciation and subsequent analysis by ICP spectrometry are described. A system embodiment includes a first valve to receive a sample into a holding loop; a plurality of syringe pumps coupled to the first valve to deliver an inline diluted sample from the first valve; and a second valve coupled to the first valve to receive the inline diluted sample from the first valve into a sample holding loop coupled to the second valve, the second valve configured to couple to at least one of an eluent source or a carrier fluid source to receive at least one of an eluent fluid or a carrier fluid to transfer the inline diluted sample from the sample holding loop to a speciation column to separate one or more species from the inline diluted sample.
    Type: Application
    Filed: December 5, 2016
    Publication date: June 8, 2017
    Inventors: Paul Field, Daniel R. Wiederin, Patrick Sullivan
  • Patent number: 9658143
    Abstract: A method for diluting a sample includes drawing an aliquot of the sample past a mixing junction. The method also includes supplying the sample to the mixing junction and supplying a second fluid to the mixing junction. The second fluid mixes with the sample at the mixing junction to generate a diluted sample. The method further includes supplying the diluted sample from the mixing junction.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 23, 2017
    Assignee: Elemental Scientific, Inc.
    Inventors: Paul Field, Kyle W. Uhlmeyer
  • Patent number: 9620343
    Abstract: A system includes a first aerosolization device (e.g., a nebulizer and a spray chamber/desolvation device in fluid communication with the nebulizer) configured to furnish a first aerosol, and a second aerosolization device (e.g., a second nebulizer and a second spray chamber/desolvation device in fluid communication with the second nebulizer) configured to furnish a second aerosol. The first aerosolization device is balanced with the second aerosolization device. The system also includes an output coupled with the first aerosolization device and the second aerosolization device. The output is configured to supply at least one of the first aerosol or the second aerosol (e.g., to a torch). The system further includes a selection device coupling the first aerosolization device and the second aerosolization device to the output. The selection device is configured to selectively provide at least one of the first aerosol or the second aerosol to the output.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: April 11, 2017
    Assignee: Elemental Scientific, Inc.
    Inventor: Paul Field
  • Patent number: 9343283
    Abstract: A method for internal standardization of cool plasma ICP-MS using one or more enriched stable isotopes includes introducing an enriched stable isotope of a chemical species to a sample containing a non-enriched isotope of the chemical species to form a sample and standard mixture. In implementations, the enriched stable isotope is introduced via an inline syringe addition to a flow of a sample solution containing a non-enriched isotope of the chemical species to be analyzed. The method also includes introducing the sample and standard mixture to an ICP-MS under cool plasma conditions. The method also includes determining an ionization amount of the enriched stable isotope by the ICP-MS. The method further includes correlating an ionization amount of the non-enriched isotope based on the determined ionization amount of the enriched stable isotope.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: May 17, 2016
    Assignee: Elemental Scientific, Inc.
    Inventors: Paul Field, Daniel R. Wiederin, Austin Schultz
  • Patent number: 8543932
    Abstract: A method including obtaining metadata specifying screens based on a business logic of the matter management workflow, generating, based on the metadata, the screens each including screen objects, where the matter management workflow includes a sequence of the screen objects specified by the metadata based on the business logic, receiving a matter management user input via the screen objects to navigate the matter management workflow, receiving a screen tester user input specifying a test instruction including a first specification based on the screen objects, generating, using the first specification and without further user intervention, a test sequence including a second specification based on the metadata, applying the test sequence to the screen objects to generate a first result depicting an evaluation of navigating the matter management workflow according to the business logic, and generating an alert in response to the first result indicating a violation to the business logic.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: September 24, 2013
    Assignee: DataCert, Inc.
    Inventors: Christopher Paul Fields, David Everett Easterby
  • Patent number: 8063022
    Abstract: The invention provides a method of preventing the formation of inhibitory antibodies in a mammal undergoing gene therapy. The method comprises administering to the mammal an immunosuppressive agent in conjunction with the gene therapy.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: November 22, 2011
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Paul A. Fields, Valder R. Arruda, Roland W. Herzog
  • Publication number: 20110265020
    Abstract: A method including obtaining metadata specifying screens based on a business logic of the matter management workflow, generating, based on the metadata, the screens each including screen objects, where the matter management workflow includes a sequence of the screen objects specified by the metadata based on the business logic, receiving a matter management user input via the screen objects to navigate the matter management workflow, receiving a screen tester user input specifying a test instruction including a first specification based on the screen objects, generating, using the first specification and without further user intervention, a test sequence including a second specification based on the metadata, applying the test sequence to the screen objects to generate a first result depicting an evaluation of navigating the matter management workflow according to the business logic, and generating an alert in response to the first result indicating a violation to the business logic.
    Type: Application
    Filed: April 23, 2010
    Publication date: October 27, 2011
    Applicant: DATACERT, INC.
    Inventors: Christopher Paul Fields, David Everett Easterby
  • Patent number: 7368111
    Abstract: Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF?) bind specifically isoforms TGF?2 and TGF?1 or both, preferentially compared with TGF?3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGF?2, neutralizing its activity, but does not bind the latent member.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 6, 2008
    Assignees: Cambridge Antibody Technology Limited, Medical Research Council
    Inventors: Julia Elizabeth Thompson, Tristan John Vaughan, Andrew James Williams, Jonathan Alexander Green, Ronald Henry Jackson, Louise Bacon, Kevin Stuart Johnson, Alison Jane Wilton, Philip Ronald Tempest, Raymond Paul Field, Steven Paul Ruddock, Gregory Paul Winter
  • Publication number: 20060216367
    Abstract: The invention may be summarized as follows. The present invention provides insecticides comprised of naturally-occurring compounds, such as, for example, PA1b-related peptides and terpenoid saponins. The present invention also provides for identification and characterization of a synergistic insecticidal effect between peptides and saponins extracted from plants. Furthermore, simplified extraction procedures are provided that avoid the use of a chloroform defatting step or a column chromatography step.
    Type: Application
    Filed: March 24, 2005
    Publication date: September 28, 2006
    Applicant: Her Majesty The Queen in Right of Canada, The Minister of Agriculture and Agri-Food
    Inventors: Wesley Taylor, Paul Fields, Daniel Sutherland
  • Publication number: 20060093570
    Abstract: This invention describes a surface treatment composition, preferably for personal use, comprising at least one surfactant and at least two different organic acids and/or salts or organic acids, and wherein the total concentration of the organic acids and/or salts in the composition is at least 0.5% (w/v). The invention further extends to a method of treating a surface, preferably hair or skin, to remove dirt and to remove or inhibit microbial growth.
    Type: Application
    Filed: October 10, 2003
    Publication date: May 4, 2006
    Inventors: Andrea Duddington, Paul Field, David Payne
  • Patent number: 6660501
    Abstract: A process for the production of a protein by cell culture, where the cells that produce the protein are cultured in the presence of a chemical agent that enhances the production of the protein.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: December 9, 2003
    Assignee: Lonza Group, AG
    Inventor: Raymond Paul Field
  • Patent number: 6593140
    Abstract: An animal cell culture medium is described which contains 2-hydroxy-2,4,6-cycloheptatrien-1-one or a derivative thereof to support the growth of animal cells, particularly in agitated cell culture at low iron concentrations.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: July 15, 2003
    Assignee: Lonza Group, AG
    Inventor: Raymond Paul Field