Abstract: An electrode array for use with an electroporation device includes a support member having a top surface and a bottom surface and defines a plurality of injection channels extending from the top surface to the bottom surface. A plurality of needle electrodes are coupled to the support member, such that distal ends of the plurality of needle electrodes extend to a needle depth below the bottom surface. The plurality of needle electrodes are arranged in a matrix pattern having rows of the needle electrodes and columns of the needle electrodes disposed along the support member. The plurality of injection channels are dispersed within the matrix pattern.