Patents by Inventor Paul Fitzpatrick
Paul Fitzpatrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240035013Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.Type: ApplicationFiled: October 19, 2022Publication date: February 1, 2024Applicant: BIOMARIN PHARMACEUTICAL INC.Inventors: Augustus O. OKHAMAFE, Sean M. BELL, G. Nick ZECHERLE, Kris ANTONSEN, Yanhong ZHANG, Kieu Ly TRAN, Paul A. FITZPATRICK, Emil D. KAKKIS, Michel Claude VELLARD, Daniel J. WENDT, Mubarack MUTHALIF
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Patent number: 11663543Abstract: Workflow sharing system and method are disclosed that allow a workflow server to provide a shared workflow, wherein the shared workflow generates at least one manifest, wherein the at least one manifest comprises a third-party interaction field, a credentials field, an input parameter field, and an output parameter field, wherein the workflow server receives a request for access to the shared workflow and transmits the at least one manifest of the shared workflow in response to the request for access to the shared workflow, wherein the at least one manifest comprises an acceptance requirement of the third-party interaction field, the credentials field, the input parameter field, and the output parameter field, wherein the workflow server receive consents of the acceptance requirement of the at least one manifest; and allows access to the shared workflow in response to the received consent of the acceptance requirement of the at least one manifest.Type: GrantFiled: April 27, 2021Date of Patent: May 30, 2023Assignee: Nintex UK Ltd.Inventors: Alain Marie Patrice Gentilhomme, Ryan Christopher Duguid, Zoe Dee Clelland, Joshua Joo Hou Tan, David Paul Fitzpatrick
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Patent number: 11549016Abstract: A hybrid crude oil and methods of making the same using man-made or natural petroleum-based waste stream products. The hybrid crude oil is composed of an oil-based solution and petroleum-based coatings that were extracted from a petroleum-containing material. This hybrid crude oil is created by elevating the temperature of the oil-based solution to or above an elevated temperature, i.e., the melting or phase-change temperature of the petroleum-based coating so that it can become liquified and dissolve into the oil-based solution and create the hybrid crude oil. The petroleum-containing material is submerged into the heated oil-based solution to cause the petroleum-based coatings to dissolve into the heated oil-based solution at the elevated temperature.Type: GrantFiled: March 26, 2020Date of Patent: January 10, 2023Inventors: Stojan Kotefski, Michael Paul Fitzpatrick, Nikola Michael Kotevski, Michael Kenwood Fitzpatrick
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Patent number: 11505790Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.Type: GrantFiled: January 11, 2019Date of Patent: November 22, 2022Assignee: BIOMARIN PHARMACEUTICAL INC.Inventors: Augustus O. Okhamafe, Sean M. Bell, G. Nick Zecherle, Kris Antonsen, Yanhong Zhang, Kieu Ly Tran, Paul A. Fitzpatrick, Emil D. Kakkis, Michel Claude Vellard, Daniel J. Wendt, Mubarack Muthalif
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Publication number: 20210264341Abstract: Workflow sharing system and method are disclosed that allow a workflow server to provide a shared workflow, wherein the shared workflow generates at least one manifest, wherein the at least one manifest comprises a third-party interaction field, a credentials field, an input parameter field, and an output parameter field, wherein the workflow server receives a request for access to the shared workflow and transmits the at least one manifest of the shared workflow in response to the request for access to the shared workflow, wherein the at least one manifest comprises an acceptance requirement of the third-party interaction field, the credentials field, the input parameter field, and the output parameter field, wherein the workflow server receive consents of the acceptance requirement of the at least one manifest; and allows access to the shared workflow in response to the received consent of the acceptance requirement of the at least one manifest.Type: ApplicationFiled: April 27, 2021Publication date: August 26, 2021Applicant: Nintex UK Ltd.Inventors: Alain Marie Patrice Gentilhomme, Ryan Christopher Duguid, Zoe Dee Clelland, Joshua Joo Hou Tan, David Paul Fitzpatrick
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Patent number: 11017341Abstract: Workflow sharing system and method are disclosed that allow a workflow server to provide a shared workflow, wherein the shared workflow generates at least one manifest, wherein the at least one manifest comprises a third-party interaction field, a credentials field, an input parameter field, and an output parameter field, wherein the workflow server receives a request for access to the shared workflow and transmits the at least one manifest of the shared workflow in response to the request for access to the shared workflow, wherein the at least one manifest comprises an acceptance requirement of the third-party interaction field, the credentials field, the input parameter field, and the output parameter field, wherein the workflow server receive consents of the acceptance requirement of the at least one manifest; and allows access to the shared workflow in response to the received consent of the acceptance requirement of the at least one manifest.Type: GrantFiled: July 11, 2018Date of Patent: May 25, 2021Assignee: Nintex UK Ltd.Inventors: Alain Marie Patrice Gentilhomme, Ryan Christopher Duguid, Zoe Dee Clelland, Joshua Joo Hou Tan, David Paul Fitzpatrick
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Publication number: 20200224032Abstract: A hybrid crude oil and methods of making the same using man-made or natural petroleum-based waste stream products. The hybrid crude oil is composed of an oil-based solution and petroleum-based coatings that were extracted from a petroleum-containing material. This hybrid crude oil is created by elevating the temperature of the oil-based solution to or above an elevated temperature, i.e., the melting or phase-change temperature of the petroleum-based coating so that it can become liquified and dissolve into the oil-based solution and create the hybrid crude oil. The petroleum-containing material is submerged into the heated oil-based solution to cause the petroleum-based coatings to dissolve into the heated oil-based solution at the elevated temperature.Type: ApplicationFiled: March 26, 2020Publication date: July 16, 2020Inventors: Stojan Kotefski, Michael Paul Fitzpatrick, Nikola Michael Kotevski, Michael Kenwood Fitzpatrick
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Publication number: 20190345475Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.Type: ApplicationFiled: January 11, 2019Publication date: November 14, 2019Applicant: BIOMARIN PHARMACEUTICAL INC.Inventors: Augustus O. Okhamafe, Sean M. Bell, G. Nick Zecherle, Kris Antonsen, Yanhong Zhang, Kieu Ly Tran, Paul A. Fitzpatrick, Emil D. Kakkis, Michel Claude Vellard, Daniel J. Wendt, Mubarack Muthalif
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Patent number: 10221408Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.Type: GrantFiled: April 15, 2016Date of Patent: March 5, 2019Assignee: BIOMARIN PHARMACEUTICAL INC.Inventors: Augustus O. Okhamafe, Sean M. Bell, G. Nick Zecherle, Kris Antonsen, Yanhong Zhang, Kieu Ly Tran, Paul A. Fitzpatrick, Emil D. Kakkis, Michel Claude Vellard, Daniel J. Wendt, Mubarack Muthalif
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Patent number: 10221578Abstract: A personnel platform facilitates maintenance on a loop sorter of a material handling system in a distribution center. The personnel platform includes wheeled axle assemblies, having left and right wheel hub assemblies connected by a lateral support structure, engaged for longitudinal travel to opposing wheel channels of a section bed of the loop sorter that guide a train of material handling carriages. The personnel platform also includes a carrier platform comprising multiple sub-platforms, such that each sub-platform is pivotally attached to an adjacent sub-platform. Further, the personnel platform includes a rail assembly having upright structures and side rail assemblies attached between an adjacent pair of upright structures. Further, the side rail assemblies extend and retract according to changing spacing between the adjacent upright structures as the personnel platform moves along a curved section.Type: GrantFiled: May 23, 2017Date of Patent: March 5, 2019Assignee: INTELLIGRATED HEADQUARTERS, LLCInventors: Murat Lee Newman, Damian Jay Saunders, Jameson Paul Fitzpatrick
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Publication number: 20190019130Abstract: Workflow sharing system and method are disclosed that allow a workflow server to provide a shared workflow, wherein the shared workflow generates at least one manifest, wherein the at least one manifest comprises a third-party interaction field, a credentials field, an input parameter field, and an output parameter field, wherein the workflow server receives a request for access to the shared workflow and transmits the at least one manifest of the shared workflow in response to the request for access to the shared workflow, wherein the at least one manifest comprises an acceptance requirement of the third-party interaction field, the credentials field, the input parameter field, and the output parameter field, wherein the workflow server receive consents of the acceptance requirement of the at least one manifest; and allows access to the shared workflow in response to the received consent of the acceptance requirement of the at least one manifest.Type: ApplicationFiled: July 11, 2018Publication date: January 17, 2019Applicant: Nintex USA, Inc.Inventors: Alain Marie Patrice Gentilhomme, Ryan Christopher Duguid, Zoe Dee Clelland, Joshua Joo Hou Tan, David Paul Fitzpatrick
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Publication number: 20180141866Abstract: A method to reclaim or recycle asphalt or asphalt components to produce reusable asphalt or asphalt components featuring (a) providing asphalt or asphalt components; (b) adding the asphalt or asphalt components to a solution at a temperature higher than the melting temperature of the asphalt binder; and optionally one or more of the following: grinding or breaking the asphalt to be reclaimed or recycled into chunks, millings or particulate prior to step a), c) screening or separating coarse aggregate and fine aggregate asphalt components from the solution of b), d) cleaning or removing asphalt binder and/or the solution from the coarse aggregate and fine aggregate asphalt components screened or separated in step c), and e) cleaning or removing asphalt binder from the solution of b).Type: ApplicationFiled: November 18, 2016Publication date: May 24, 2018Inventors: Stojan KOTEFSKI, Michael Paul FITZPATRICK, Nikola KOTEVSKI, Michael Kenwood FITZPATRICK
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Publication number: 20170342727Abstract: A personnel platform facilitates maintenance on a loop sorter of a material handling system in a distribution center. The personnel platform includes wheeled axle assemblies, having left and right wheel hub assemblies connected by a lateral support structure, engaged for longitudinal travel to opposing wheel channels of a section bed of the loop sorter that guide a train of material handling carriages. The personnel platform also includes a carrier platform comprising multiple sub-platforms, such that each sub-platform is pivotally attached to an adjacent sub-platform. Further, the personnel platform includes a rail assembly having upright structures and side rail assemblies attached between an adjacent pair of upright structures. Further, the side rail assemblies extend and retract according to changing spacing between the adjacent upright structures as the personnel platform moves along a curved section.Type: ApplicationFiled: May 23, 2017Publication date: November 30, 2017Inventors: Murat Lee Newman, Damian Jay Saunders, Jameson Paul Fitzpatrick
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Publication number: 20160362675Abstract: Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.Type: ApplicationFiled: April 15, 2016Publication date: December 15, 2016Inventors: Augustus O. Okhamafe, Sean M. Bell, G. Nick Zecherle, Kris Antonsen, Yanhong Zhang, Kieu Ly Tran, Paul A. Fitzpatrick, Emil D. Kakkis, Michel Claude Vellard, Daniel J. Wendt, Mubarack Muthalif
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Patent number: 9366157Abstract: A lube oil supply system of a turbine system and method of regulating lube oil temperatures. In one embodiment, the system includes a first valve positioned on a lube oil bypass conduit in fluid communication with a lube oil supply line to a heat exchanger. The first valve may be positioned in parallel with the heat exchanger. The system may also include a second valve positioned on a cooling fluid supply line in fluid communication with the heat exchanger, and a lube oil control system operably connected to the first valve and the second valve. The lube oil control system may be configured to modify a position of at least one of the first valve, or the second valve in response to determining a temperature of a lube oil of the lube oil supply line differs from a predetermined lube oil temperature threshold.Type: GrantFiled: August 8, 2013Date of Patent: June 14, 2016Assignee: General Electric CompanyInventors: Matthew Paul Fitzpatrick, Matthew Kenneth King, Jon Michael Merchant, Steven Paul Scarlata
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Patent number: 9354221Abstract: Various embodiments of the invention include a system having: at least one computing device at least one computing device configured to monitor a lubrication oil by performing actions including: determining an initial ideal remaining life for the lubrication oil; determining a temperature-based remaining life for the lubrication oil based upon a temperature measurement of the lubrication oil; calculating a contamination factor of the lubrication oil based upon a contamination sample of the lubrication oil; determining an updated ideal life remaining for the lubrication oil based upon the contamination factor, the initial ideal remaining life, and the temperature-based remaining life; and determining an actual life remaining for the lubrication oil based upon the updated ideal life remaining and a life loss factor.Type: GrantFiled: April 29, 2013Date of Patent: May 31, 2016Assignee: General Electric CompanyInventors: Keegan Saunders O'Donnell, Matthew Paul Fitzpatrick
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Patent number: 9303540Abstract: Various embodiments of the invention include an apparatus for monitoring a lubrication oil in a turbomachine oil reservoir, the apparatus having: a housing section including: a casing; a base plate and a back support coupled with the casing; an oil intake conduit extending through the base plate, the oil intake conduit for fluidly connecting with the turbomachine oil reservoir; a pump fluidly connected with the oil intake conduit; an oil analyzer fluidly connected with the pump; and a drain conduit fluidly connected with the oil analyzer and extending through the base plate; and a mount coupled with the housing section, the mount for coupling with the turbomachine oil reservoir.Type: GrantFiled: April 29, 2013Date of Patent: April 5, 2016Assignee: General Electric CompanyInventors: Keegan Saunders O'Donnell, Matthew Paul Fitzpatrick, Joseph Thomas Lisowski
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Publication number: 20150044036Abstract: A lube oil supply system of a turbine system and method of regulating lube oil temperatures. In one embodiment, the system includes a first valve positioned on a lube oil bypass conduit in fluid communication with a lube oil supply line to a heat exchanger. The first valve may be positioned in parallel with the heat exchanger. The system may also include a second valve positioned on a cooling fluid supply line in fluid communication with the heat exchanger, and a lube oil control system operably connected to the first valve and the second valve. The lube oil control system may be configured to modify a position of at least one of the first valve, or the second valve in response to determining a temperature of a lube oil of the lube oil supply line differs from a predetermined lube oil temperature threshold.Type: ApplicationFiled: August 8, 2013Publication date: February 12, 2015Applicant: General Electric CompanyInventors: Matthew Paul Fitzpatrick, Matthew Kenneth King, Jon Michael Merchant, Steven Paul Scarlata
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Publication number: 20140324361Abstract: Various embodiments of the invention include a system having: at least one computing device at least one computing device configured to monitor a lubrication oil by performing actions including: determining an initial ideal remaining life for the lubrication oil; determining a temperature-based remaining life for the lubrication oil based upon a temperature measurement of the lubrication oil; calculating a contamination factor of the lubrication oil based upon a contamination sample of the lubrication oil; determining an updated ideal life remaining for the lubrication oil based upon the contamination factor, the initial ideal remaining life, and the temperature-based remaining life; and determining an actual life remaining for the lubrication oil based upon the updated ideal life remaining and a life loss factor.Type: ApplicationFiled: April 29, 2013Publication date: October 30, 2014Applicant: General Electric CompanyInventors: Keegan Saunders O'Donnell, Matthew Paul Fitzpatrick
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Publication number: 20140318223Abstract: Various embodiments of the invention include an apparatus for monitoring a lubrication oil in a turbomachine oil reservoir, the apparatus having: a housing section including: a casing; a base plate and a back support coupled with the casing; an oil intake conduit extending through the base plate, the oil intake conduit for fluidly connecting with the turbomachine oil reservoir; a pump fluidly connected with the oil intake conduit; an oil analyzer fluidly connected with the pump; and a drain conduit fluidly connected with the oil analyzer and extending through the base plate; and a mount coupled with the housing section, the mount for coupling with the turbomachine oil reservoir.Type: ApplicationFiled: April 29, 2013Publication date: October 30, 2014Applicant: General Electric CompanyInventors: Keegan Saunders O'Donnell, Matthew Paul Fitzpatrick, Joseph Thomas Lisowski