Patents by Inventor Paul Francis Alewood
Paul Francis Alewood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8765677Abstract: This invention relates to an isolated, synthetic or recombinant peptide, wherein the peptide comprises the sequence: C K G K G A Xaa1 C R Xaa2 Xaa3 Xaa4 Y Xaa5 C C Xaa6 G Xaa7 C R Xaa8 Xaa9 R C SEQ ID NO: 1 wherein Xaa1, Xaa3, Xaa4, Xaa6, Xaa7 and Xaa8 are independently selected from serine and threonine; Xaa2 is selected from arginine and lysine; Xaa5 is selected from aspartic acid and glutamic acid; and Xaa9 is selected from glycine, alanine, valine, leucine and isoleucine.Type: GrantFiled: September 21, 2010Date of Patent: July 1, 2014Assignees: The University of Queensland, The University of SydneyInventors: Richard Lewis, David John Adams, Geza Berecki, Roger Drinkwater, Paul Francis Alewood, MacDonald James Christie
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Publication number: 20120329717Abstract: This invention relates to an isolated, synthetic or recombinant peptide, wherein the peptide comprises the sequence: C K G K G A Xaa1 C R Xaa2 Xaa3 Xaa4 Y Xaa5 C C Xaa6 G Xaa7 C R Xaa8 Xaa9 R C SEQ ID NO: 1 wherein Xaa1, Xaa3, Xaa4, Xaa6, Xaa7 and Xaa8 are independently selected from serine and threonine; Xaa2 is selected from arginine and lysine; Xaa5 is selected from aspartic acid and glutamic acid; and Xaa9 is selected from glycine, alanine, valine, leucine and isoleucine.Type: ApplicationFiled: September 21, 2010Publication date: December 27, 2012Inventors: Richard Lewis, John Adams David, Berecki Geza, Roger Drinkwater, Paul Francis Alewood, James Christie MacDonald
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Publication number: 20120277166Abstract: The invention relates to an isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: ApplicationFiled: May 25, 2011Publication date: November 1, 2012Applicant: XENOME LIMITEDInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Publication number: 20110195909Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO: 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not Mr1A, Mr1B, Mar2, CMrV1A, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: ApplicationFiled: March 18, 2011Publication date: August 11, 2011Applicant: XENOME LTD.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Publication number: 20110040087Abstract: Peptide mimetics of structure X herein which (i) provide a wide range of sidechain functions at all sidechain positions, (ii) can be incorporated in a peptide sequence, (iii) can be readily synthesized and (iv) have a variety of conformations. There is also provided a novel process which can provide valuable intermediates in relation to production of peptide mimetics of structure X which intermediates have a high degree of chemo- and stereo-selectivity. Preferred mimetics include structures I, II, III, IV, V and VI.Type: ApplicationFiled: August 18, 2010Publication date: February 17, 2011Applicant: Mimetica Pty Ltd.Inventors: Peter Joseph Cassidy, Peter Alan Hunt, Paul Francis Alewood, Tracie Elizabeh Ramsdale
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Patent number: 7851444Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide comprising the following sequence of amino acids: Xaa1 Xaa2 Gly Val Cys Cys Gly Tyr Lys Leu Cys His Pro Cys SEQ ID NO. 3 where Xaa1 is a N-terminal Xaa1 is a N-terminal pyroglutamate (pGlu) or D-pyroglutamate (DpGlu) residue; and Xaa2 is Asn or a deletion; or such a sequence in which one or more Cys is replaced with its corresponding D-amino acid and/or one or more amino acid residues other than Cys has undergone a side chain modification, or a salt, ester, amide or prodrug thereof. The invention also relates to pharmaceutical compositions comprising these peptides and the use of these peptides in the prophylaxis or treatment of conditions, such as but not limited to, pain, inflammation, incontinence, cardiovascular conditions and mood disorders.Type: GrantFiled: December 2, 2003Date of Patent: December 14, 2010Assignee: Xenome Ltd.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Publication number: 20090275498Abstract: The invention relates to an isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: ApplicationFiled: November 2, 2007Publication date: November 5, 2009Applicant: The University of QueenslandInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Publication number: 20090275727Abstract: This invention provides novel compounds useful for the synthesis of peptide mimetics, and describes the use of these compounds for the synthesis of novel reverse turn mimetics. The reverse turn mimetics of the invention have the general structure X wherein the variables are as defined herein.Type: ApplicationFiled: April 24, 2009Publication date: November 5, 2009Applicant: MIMETICA PTY LIMITEDInventors: Peter J. Cassidy, Paul Francis Alewood, Andrea Joy Vernall
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Publication number: 20090088389Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO: 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not Mr1A, Mr1B, Mar2, CMrV1A, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: ApplicationFiled: October 14, 2008Publication date: April 2, 2009Applicant: XENOME LTD.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7507717Abstract: An isolated, synthetic or recombinant X-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO:3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not MrIA, MrIB, Mar2, CMrVIA, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: GrantFiled: December 2, 2003Date of Patent: March 24, 2009Assignee: Xenome Ltd.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7326682Abstract: The invention relates to an isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: GrantFiled: August 13, 2004Date of Patent: February 5, 2008Assignee: Xenome LimitedInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Patent number: 7312195Abstract: This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.Type: GrantFiled: February 7, 2005Date of Patent: December 25, 2007Assignee: The University of QueenslandInventors: David James Craik, Norelle Lee Daly, Katherine Justine Nielsen, Christopher John Armishaw, Richard Clark, Paul Francis Alewood
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Patent number: 7101849Abstract: An isolated, synthetic, or recombinant ?-conotoxin peptide in which the fourth loop between cysteine residues 5 and 6 comprises SEQ ID NO: 1 or such a sequence which has undergone one or more amino acid substitutions or side chain modifications, and uses therefor. SEQ ID NO: 1 comprises the amino acid sequence SGTVGR.Type: GrantFiled: April 16, 1999Date of Patent: September 5, 2006Assignee: The University of QueenslandInventors: Roger Desmond Drinkwater, Richard James Lewis, Paul Francis Alewood, Katherine Justine Nielsen
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Patent number: 6849601Abstract: The present invention relates to novel peptides and derivatives thereof useful as selective ?1-adrenoceptor antagonists which ability of inhibiting the agonist action of agonist noradrenaline on the ?1-adrenoceptor is greater than their ability of inhibiting the action of agonist noradrenaline on the other ?-adrenoceptors. The invention also relates to pharmaceutical compositions comprising these peptides.Type: GrantFiled: October 1, 1999Date of Patent: February 1, 2005Assignee: The University of QueenslandInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Patent number: 6794361Abstract: The invention relates to an isolated, synthetic or recombinant &khgr;-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: GrantFiled: June 27, 2001Date of Patent: September 21, 2004Assignee: The University of QueenslandInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe