Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide 5 and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: The present invention relates to a transcription factor gene that plays a key role in Solanaceae fruit ripening. Plants overexpressing the gene have fruits with deeper pigmentation and ripen more rapidly than controls. The invention also relates to transgenic plants comprising said gene, and methods of making said plants.

Abstract: A heat exchanger for transferring heat from a hot gas to a fluid includes two or more corrugated fin structures defining a plurality of hot gas flow channels extending in a generally linear first direction. A fluid conduit includes an outer wall at least partially bonded to at least two of the corrugated fin structures. The fluid conduit defines a plurality of sequentially arranged flow passes for the fluid traveling therethrough. Each of the plurality of flow passes directs the fluid in a direction generally perpendicular to the first direction.

Abstract: A heat exchanger for transferring heat from a hot gas to a fluid includes two or more corrugated fm structures defining a plurality of hot gas flow channels. Each of the plurality of hot gas flow channels extends in a generally linear first direction. A fluid conduit includes an outer wall at least partially bonded to at least two of the corrugated fin structures. The fluid conduit defines a plurality of sequentially arranged flow passes for the fluid traveling therethrough. Each of the plurality of flow passes directs the fluid in a direction generally perpendicular to the first direction.

Abstract: A heat exchanger for transferring heat from a hot gas to a fluid includes two or more corrugated fin structures defining a plurality of hot gas flow channels extending in a generally linear first direction. A fluid conduit includes an outer wall at least partially bonded to at least two of the corrugated fin structures. The fluid conduit defines a plurality of sequentially arranged flow passes for the fluid traveling therethrough. Each of the plurality of flow passes directs the fluid in a direction generally perpendicular to the first direction.

Abstract: Described are various embodiments of a resilient ring-shaped clip installation system and method, as well as handling apparatus associated therewith. In one embodiment, the apparatus comprises gripping fingers circumferentially disposed and radially actuated to grip and radially compress the clip, and stripping rods axially actuated to axially engage and strip the compressed clip from the gripping fingers.

Abstract: Described are various embodiments of a resilient ring-shaped clip installation system and method, as well as handling apparatus associated therewith. In one embodiment, the apparatus comprises gripping fingers circumferentially disposed and radially actuated to grip and radially compress the clip, and stripping rods axially actuated to axially engage and strip the compressed clip from the gripping fingers.

Abstract: Systems, methods, and apparatus relating to the use of Stirling engine technology to convert heat, such as from solar radiation, to mechanical work or electricity. Apparatus, systems, components, and methods relating to energy converting apparatus are described herein. In one aspect, the invention relates to the field alignment of panels and the assembly of a concentrator. In another aspect, a passive balancer is used in combination with a ring frame and other moving masses to reduce engine forces and vibration on the structure of the energy converting apparatus while maintaining properly constrained alignment of various suspended masses. In yet another aspect, the invention relates to various over-insolation control and management strategy to prevent overheating of the energy converting apparatus or components and subsystems thereof.

Abstract: The present invention relates to a transcription factor gene that plays a key role in Solanaceae fruit ripening. Plants overexpressing the gene have fruits with deeper pigmentation and ripen more rapidly than controls. The invention also relates to transgenic plants comprising said gene, and methods of making said plants.

Abstract: In one aspect the invention relates to an electrical circuit for use with a generator having an output port, the circuit to modify one of an electric current or voltage from the generator. The circuit includes a rectifier to convert the alternating current from the generator to direct current, the rectifier having a first port and a second port, the rectifier first port in communication with the output port of the generator; and a direct current to alternating current inverter to convert the direct current from the rectifier to alternating current, the inverter having a first port and a second port, the first port of the inverter in communication with the second port of the rectifier. In one embodiment, the generator is a linear alternator positioned within an energy converting apparatus comprising a Stirling engine having a piston such that motion of the piston drives the linear alternator.

Abstract: A method and system of generating, funding, and distributing multiple jackpots in a game such as poker, specifically such as Texas Hold 'Em. The jackpots may be separate, independent bad beat jackpots that pay out at different intervals due to having independent triggering conditions that have different odds of occurring. Preferably, the triggering condition for each jackpot may be a losing player's hand strength. The specific values for the triggering conditions may be chosen by random, may be generally evenly distributed over the number of jackpots, may be determined by an algorithm, e.g., one that relies on the odds of each hand occurring, or by another method. The jackpots may be funded from rakes collected from substantially every hand that is played—subject to certain prerequisites being established—such that each jackpot may be considered progressive in that it grows over time.

Abstract: Systems, methods, and apparatus relating to the use of Stirling engine technology to convert heat, such as from solar radiation, to mechanical work or electricity. Apparatus, systems, components, and methods relating to energy converting apparatus are described herein. In one aspect, the invention relates to the field alignment of panels and the assembly of a concentrator. In another aspect, a passive balancer is used in combination with a ring frame and other moving masses to reduce engine forces and vibration on the structure of the energy converting apparatus while maintaining properly constrained alignment of various suspended masses. In yet another aspect, the invention relates to various over-insolation control and management strategy to prevent overheating of the energy converting apparatus or components and subsystems thereof.

Abstract: A method and system of generating, funding, and distributing multiple jackpots in a game such as poker, specifically such as Texas Hold 'Em. The jackpots may be separate, independent bad beat jackpots that pay out at different intervals due to having independent triggering conditions that have different odds of occurring. Preferably, the triggering condition for each jackpot may be a losing player's hand strength. The specific values for the triggering conditions may be chosen by random, may be generally evenly distributed over the number of jackpots, may be determined by an algorithm, e.g., one that relies on the odds of each hand occurring, or by another method. The jackpots may be funded from rakes collected from substantially every hand that is played—subject to certain prerequisites being established—such that each jackpot may be considered progressive in that it grows over time.

Abstract: Systems, methods, and apparatus relating to the use of Stirling engine technology to convert heat, such as from solar radiation, to mechanical work or electricity. Apparatus, systems, components, and methods relating to energy converting apparatus are described herein. In one aspect, the invention relates to the field alignment of panels and the assembly of a concentrator. In another aspect, a passive balancer is used in combination with a ring frame and other moving masses to reduce engine forces and vibration on the structure of the energy converting apparatus while maintaining properly constrained alignment of various suspended masses. In yet another aspect, the invention relates to various over-insolation control and management strategy to prevent overheating of the energy converting apparatus or components and subsystems thereof.

Abstract: A system and process for aggregating and displaying information about a plurality of gaming tables to a user comprising a stacking component and a console area. The console area displays one or more active tables, while the stacking component displays changing information about each table the user has open. The stacking component may include one or more sub-components or dialogs, including a table list dialog, a player information dialog, a hand information dialog and/or an action area dialog.

Abstract: The present invention provides new antifibrillogenic agents and peptides, compositions and cells containing same, compositions that bind to same, effective therapeutics for preventing or delaying the progression of, e.g., Alzheimer's disease and diabetes, methods for optimizing antifibrillogenic agents, and methods of using the antifibrillogenic agents, peptides, compositions, and cells of the invention for detecting and/or inhibiting amyloid fibril formation.

Abstract: A system and process for aggregating and displaying information about a plurality of gaming tables to a user comprising a stacking component and a console area. The console area displays one or more active tables, while the stacking component displays changing information about each table the user has open. The stacking component may include one or more sub-components or dialogs, including a table list dialog, a player information dialog, a hand information dialog and/or an action area dialog.

Abstract: Systems, methods, and apparatus relating to the use of Stirling engine technology to convert heat, such as from solar radiation, to mechanical work or electricity. Apparatus, systems, components, and methods relating to energy converting apparatus are described herein. In one aspect, the invention relates to the field alignment of panels and the assembly of a concentrator. In another aspect, a passive balancer is used in combination with a ring frame and other moving masses to reduce engine forces and vibration on the structure of the energy converting apparatus while maintaining properly constrained alignment of various suspended masses. In yet another aspect, the invention relates to various over-insolation control and management strategy to prevent overheating of the energy converting apparatus or components and subsystems thereof.

Abstract: In one aspect the invention relates to an electrical circuit for use with a generator having an output port, the circuit to modify one of an electric current or voltage from the generator. The circuit includes a rectifier to convert the alternating current from the generator to direct current, the rectifier having a first port and a second port, the rectifier first port in communication with the output port of the generator; and a direct current to alternating current inverter to convert the direct current from the rectifier to alternating current, the inverter having a first port and a second port, the first port of the inverter in communication with the second port of the rectifier. In one embodiment, the generator is a linear alternator positioned within an energy converting apparatus comprising a Stirling engine having a piston such that motion of the piston drives the linear alternator.