Patents by Inventor Paul Frederic Worley

Paul Frederic Worley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Identifying Agents that Promote Axonal Development
    Publication number: 20110171230
    Abstract: The present invention is based on the discovery of a novel function of an FKBP proline isomerases in chemotropic nerve guidance and axon regeneration through gating of TRPC1 channel activity. Accordingly, there are provided methods for identifying an agent that inhibits FKBP52 binding to TRPC1. Also provided are methods for identifying an inhibitor of an FKBP52-TRPC1 signaling pathway by contacting a cell expressing TRPC1 and FKBP52 with a test agent and detecting a change in agonist-induced calcium flux of TRPC1. Further provided are methods of enhancing axonal outgrowth by inhibiting the activity of FKBP52 in a neuronal growth cone, and methods of enhancing axonal regeneration in a subject in need thereof by administering an agent that inhibits the activity of FKBP52.
    Type: Application
    Filed: April 24, 2009
    Publication date: July 14, 2011
    Applicant: The Johns Hopkins University
    Inventors: Paul Frederic Worley, Guo-li Ming, Joseph P. Steiner