Patents by Inventor Paul Frederik Grundeman
Paul Frederik Grundeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11376123Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet attached to a supporting element, which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets.Type: GrantFiled: December 3, 2019Date of Patent: July 5, 2022Assignee: DSM IP ASSETS B.V.Inventors: Paul Frederik Gründeman, Jolanda Kluin, Karlien Kristal Boon-Ceelen, Thomas König
-
Patent number: 11266498Abstract: The present invention provides a method of making a leaflet assembly, the leaflet assembly thus made and a prosthetic valve.Type: GrantFiled: August 22, 2019Date of Patent: March 8, 2022Assignee: DSM IP ASSETS B.V.Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas König
-
Publication number: 20200107928Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet attached to a supporting element, which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets.Type: ApplicationFiled: December 3, 2019Publication date: April 9, 2020Inventors: Paul Frederik GRÜNDEMAN, Jolanda KLUIN, Karlien Kristal BOON-CEELEN, Thomas KÖNIG
-
Patent number: 10583003Abstract: The present relates to a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet, a supporting element, and a stent to which the leaflet and supporting element are attached, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising:—providing a woven textile structure,—forming the leaflet and the supporting element from this textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, and—forming the valve therewith, wherein the textile structure has a single layer thickness of between 40 to 150 ?m and comprises yarn comprising polymeric filaments, the yarn having a linear density of less than 120 dtex and an elongation at break of 10% or less, and wherein the leaflet is attached to the stent by making stitches through at lType: GrantFiled: May 6, 2015Date of Patent: March 10, 2020Assignee: DSM IP ASSETS B.V.Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas König
-
Patent number: 10524902Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.Type: GrantFiled: December 28, 2017Date of Patent: January 7, 2020Assignee: DSM IP ASSETS B.V.Inventors: Paul Frederik Gründeman, Jolanda Kluin, Karlien Kristal Boon-Ceelen, Thomas König
-
Publication number: 20190374338Abstract: The present invention provides a method of making a leaflet assembly, the leaflet assembly thus made and a prosthetic valve.Type: ApplicationFiled: August 22, 2019Publication date: December 12, 2019Inventors: Paul Frederik GRUNDEMAN, Jolanda KLUIN, Karlien Kristel BOON-CEELEN, Thomas KÖNIG
-
Patent number: 10441414Abstract: The present invention provides a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least one leaflet attached to a supporting element, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a textile structure, and forming the leaflet assembly from the textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, wherein the textile structure is made by weaving warp and fill threads into a two-layer woven fabric having two stacked and interconnected layers, the two layers having selvedges at one longitudinal edge, and wherein forming the leaflet assembly comprises connecting two lateral edges of a single piece of the fabric to make a substantially tubular structure wherein the inner layeType: GrantFiled: May 6, 2015Date of Patent: October 15, 2019Assignee: DSM IP ASSETS B.V.Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas König
-
Patent number: 10098992Abstract: Heart support device for circulatory assistance, with an internal member (6) to be disposed inside a heart lumen (13) and having a dynamic volume body. The internal member (6) has a substantially stiff wall strengthening portion (8) arranged to engage an inner wall surface (12a) of the heart (10) in operation and a dynamic member (9) that is inflatable to assist pumping action of the heart (10).Type: GrantFiled: June 30, 2015Date of Patent: October 16, 2018Assignee: Stichting Katholieke UniversiteitInventors: Daniël Immanuel Michaël van Dort, Harry Suryapranata, Paul Frederik Gründeman, Jakob Roelf Lahpor
-
Patent number: 10070855Abstract: A surgical device (5) for application in a treatment performed on the human or animal body (1) with the aim of providing access to a surgical site in the body, includes at least one inflatable chamber (70, 71, 72) which can be inflated from a collapsed state to an expanded state, in which expanded state the device is suitable for exerting a force on an organ or tissue at the surgical site, at least one elongated flexible member (8, 80), which member at its proximal end (801) is operatively connected to the device, and which member has a length to allow the distal end (800) of the member to be fixed to a fixation site (100, 101) outside of the body, and methods of using this device.Type: GrantFiled: June 12, 2014Date of Patent: September 11, 2018Assignee: UMC UTRECHT HOLDING B.V.Inventors: Paul Frederik Gründeman, Paul Barteld Kwant
-
Patent number: 10039640Abstract: The invention relates to a prosthetic valve comprising a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.Type: GrantFiled: May 6, 2015Date of Patent: August 7, 2018Assignee: DSM IP ASSETS B.V.Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas König
-
Publication number: 20180193137Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.Type: ApplicationFiled: December 28, 2017Publication date: July 12, 2018Inventors: Paul Frederik GRÜNDEMAN, Jolanda KLUIN, Karlien Kristal BOON-CEELEN, Thomas KÖNIG
-
Publication number: 20170189172Abstract: The present invention relates to a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least two leaflets attached to a supporting element, the leaflets having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a single piece of fabric, made by weaving warp and fill threads into a seamless tubular woven fabric having at least one stabilized edge, and forming the fabric into a leaflet assembly having an inner layer forming the leaflets with the stabilized edge forming the free margin, and an outer layer forming the supporting element. With this method a prosthetic valve can be made from a single piece of fabric made by tubular weaving techniques, and resulting in a valve with high reliability and durability.Type: ApplicationFiled: May 6, 2015Publication date: July 6, 2017Inventors: Paul Frederik GRUNDEMAN, Jolanda KLUIN, Thomas KÖNIG, Karlien Kristel BOON-CEELEN
-
Publication number: 20170136162Abstract: Heart support device for circulatory assistance, with an internal member (6) to be disposed inside a heart lumen (13) and having a dynamic volume body. The internal member (6) has a substantially stiff wall strengthening portion (8) arranged to engage an inner wall surface (12a) of the heart (10) in operation and a dynamic member (9) that is inflatable to assist pumping action of the heart (10).Type: ApplicationFiled: June 30, 2015Publication date: May 18, 2017Applicant: STICHTING KATHOLIEKE UNIVERSITEITInventors: Daniël Immanuel Michaël van Dort, Harry Suryapranata, Paul Frederik Gründeman, Jakob Roelf Lahpor
-
Publication number: 20170071730Abstract: The present invention provides a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least one leaflet attached to a supporting element, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a textile structure, and forming the leaflet assembly from the textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, wherein the textile structure is made by weaving warp and fill threads into a two-layer woven fabric having two stacked and interconnected layers, the two layers having selvedges at one longitudinal edge, and wherein forming the leaflet assembly comprises connecting two lateral edges of a single piece of the fabric to make a substantially tubular structure wherein the inner layeType: ApplicationFiled: May 6, 2015Publication date: March 16, 2017Inventors: Paul Frederik GRUNDEMAN, Jolanda KLUIN, Karlien Kristel BOON-CEELEN, Thomas KÖNIG
-
Publication number: 20170065408Abstract: The present relates to a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet, a supporting element, and a stent to which the leaflet and supporting element are attached, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising:—providing a woven textile structure,—forming the leaflet and the supporting element from this textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, and—forming the valve therewith, wherein the textile structure has a single layer thickness of between 40 to 150 ?m and comprises yarn comprising polymeric filaments, the yarn having a linear density of less than 120 dtex and an elongation at break of 10% or less, and wherein the leaflet is attached to the stent by making stitches through at lType: ApplicationFiled: May 6, 2015Publication date: March 9, 2017Applicant: DSM IP Assets B.V.Inventors: Paul Frederik GRUNDEMAN, Jolanda KLUIN, Karlien Kristel BOON-CEELEN, Thomas KÖNIG
-
Publication number: 20170065411Abstract: The invention relates to a prosthetic valve comprising a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.Type: ApplicationFiled: May 6, 2015Publication date: March 9, 2017Inventors: Paul Frederik GRUNDEMAN, Jolanda KLUIN, Karlien Kristel BOON-CEELEN, Thomas KÖNIG
-
Publication number: 20160120531Abstract: A surgical device (5) for application in a treatment performed on the human or animal body (1) with the aim of providing access to a surgical site in the body, includes at least one inflatable chamber (70, 71, 72) which can be inflated from a collapsed state to an expanded state, in which expanded state the device is suitable for exerting a force on an organ or tissue at the surgical site, at least one elongated flexible member (8, 80), which member at its proximal end (801) is operatively connected to the device, and which member has a length to allow the distal end (800) of the member to be fixed to a fixation site (100, 101) outside of the body, and methods of using this device.Type: ApplicationFiled: June 12, 2014Publication date: May 5, 2016Inventors: Paul Frederik GRÜNDEMAN, Paul Barteld KWANT
-
Patent number: 8764646Abstract: A surgical device for application in a treatment performed on the human or animal body with the aim of providing access to a surgical site in the body by exerting a force, upon expansion of the device at the location of the surgical site, on the organs and/or tissues at the surgical site, e.g. for mobilizing and/or supporting organs and/or tissues, the surgical device including an expansion structure, at least one fluid reservoir, and a conduit for conveying fluid from the reservoir to the expansion structure.Type: GrantFiled: April 29, 2004Date of Patent: July 1, 2014Assignee: UMC Utrecht Holding B.V.Inventor: Paul Frederik Gründeman
-
Patent number: 8092477Abstract: A device (1) for making a cut in a tissue, such as a blood vessel (2), capsule and the like, includes a trocar (3), the distal end (4) of which can be placed on the tissue (2) and inside which trocar (3) a reduced pressure can be generated for holding the tissue pressed against the distal end (3) under the influence of the reduced pressure, as well as a cutting member (6) located in the trocar (3), such that the tissue (2) pressed against the distal end (4) and the cutting member (6) can be moved relative to one another to make the cut (9). A tissue support (10) is provided in the trocar (3) close to the distal end (4) thereof with which the tissue (2) that extends over the lumen of the trocar (3) can make contact under the influence of the reduced pressure inside the trocar (3).Type: GrantFiled: May 13, 2004Date of Patent: January 10, 2012Assignee: UMC Utrecht Holding B.V.Inventors: Paul Frederik Grundeman, Hendricus Jacobus Mansvelt Beck
-
Patent number: 6790171Abstract: Invention relates to a cannula and a screw pump for use in a mechanical circulatory support device, in particular a transventricular circulatory support device. The cannula according to the present invention comprises a tubular member made of a flexible, collapsible material having a diameter between 0.5 cm and 3 cm, preferably between 1 cm and 2.5 cm. The invention also relates to an inflatable screw pump for use in circulatory support system which comprises a flexible central drive shaft and an inflatable body having a free edge defining a spiral shaped contour around the central drive shaft and an inner edge connected to the drive shaft. The Archimedes type screw pump may be used in conjunction with the flexible cannula.Type: GrantFiled: March 1, 2002Date of Patent: September 14, 2004Assignee: Universitair Medisch Cenrum UtrechtInventors: Paul Frederik Gründeman, Cornelis Wilhelmus Jozef Verlaan, Cornelius Borst, Hendricus Jacobus Mansvelt Beck