Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a eczema segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, papulation, lichenification, and excoriation for the cropped image; and generating a full body EASI score based on the eczema segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a lesion segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, induration, desquamation for the cropped image; and generating a full body severity score based on the lesion segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: The present invention relates, in part, to certain cancer biomarkers and use thereof in methods for treating cancer, such as in evaluating and/or predicting patient responses to treatment with a CXCR4 inhibitor optionally in combination with a immunotherapeutic agent, in patients with a cancer such as melanoma, including resectable and unresectable melanoma. The present invention also provides a biomarker expression platform, which is a combination of a set of genes or biomarkers that are correlated with response to a CXCR4 inhibitor in a tumor as well as a normalization gene set. A method and system of using the biomarker expression platform to derive biomarker signatures of anti-tumor response and to test patient samples for predictive biomarker signatures are also disclosed.

Abstract: The present invention relates, in part, to certain serum biomarkers and use thereof in methods for treating cancer, such as in evaluating and/or in additional methods such as predicting patient responses to treatment with a CXCR4 inhibitor optionally in combination with a immunotherapeutic agent, in patients with a cancer such as melanoma, including resectable and unresectable melanoma.

Abstract: A device for treating a continuously conveyed thread group in order to produce tire cord has a roller pair for locally softening the thread group, wherein each roller (3, 4) is provided with a toothing formation. When the thread group is guided through between the rollers (3, 4), it is deformed by the mechanical loading of the teeth. The rollers (3, 4) can be driven in a separate manner directly or indirectly by way of actuable electric motors, as a result of which the gap spacings (A) and (B) can be set precisely identically. The axle spacing (C) of the two rollers (3, 4) can be set depending on the fabric thickness and the fabric type.

Abstract: A device for treating a continuously conveyed thread group in order to produce tyre cord has a roller pair for locally softening the thread group, wherein each roller (3, 4) is provided with a toothing formation. When the thread group is guided through between the rollers (3, 4), it is deformed by the mechanical loading of the teeth. The rollers (3, 4) can be driven in a separate manner directly or indirectly by way of actuable electric motors, as a result of which the gap spacings (A) and (B) can be set precisely identically. The axle spacing (C) of the two rollers (3, 4) can be set depending on the fabric thickness and the fabric type.

Abstract: The invention relates to a device for performing heat treatments comprising at least one treatment module (10), which has a first and a second heating section (11a, 11b). Hot air (L) is introduced into the heating sections (11a, 11b) via a line connection (13). After the treatment, the hot air (L) is discharged via suction means (14). The suction means are arranged at the end faces of the heating sections (11a, 11b).

Abstract: Erosive working machine for cutting prepared closed inner shapes (15) and closed outer shapes (16) of a workpiece (12) fixed by a workpiece holder by means of a filamentary or strip electrode (14) arranged on guidance means (13, 18). At least one guidance means (13, 18) is arranged on a motor-rotatable rotating mechanism (20) in such a way that the center line (23) of rotating mechanism (20) at at least one geometrical locus coincides with the center of the cross-section of electrode (14). Thus, during the erosion process, a collision between the guidance means (13, 18) and the closed inner shape (15) or closed outer shape (16) or a tool holder (11) is avoided.

Abstract: A movement control apparatus, which can be constructed as an accessory, provides in addition to the primary process-controlled movement of the electrode circular a secondary movement. The secondary movement is imparted to the electrode through a drive arm fixed at one end to the bottom slide of a cross-slide on which the electrode is also fixed and attached pivotably at the other end to an eccentric point of a rotating spindle. The mechanism for rotating the spindle is so designed that the degree of eccentricity of the eccentric point may be adjusted mechanically while the spindle is rotating. The eccentricity may also be controlled by the action of a cam follower which runs along a template, so that the circular movement of the electrode is controlled by the template in a copying mode.

Abstract: An assembly such as a tool head for a spark erosion profiling machine tool comprises an elongate tool holding member having first and second opposed lengthwise bearing surfaces and third and fourth opposed lengthwise bearing surfaces. By way of example the member can be square, the bearing surfaces then being the four long sides of the member. The member is partly housed in a housing wherein there are mounted bearings which support the member for movement in the direction of its length with respect to the housing. The bearings can comprise discrete circulating roller bearing shoes and they are in abutting contact with the member at five positions in the region of each of two planes spaced apart along the length of the member by a calculated optimum distance.

Abstract: A workpiece-supporting table of an electro erosion machining equipment is provided with a mechanism for subjecting the workpiece to a circling motion of continuously variable radius during operation from zero to a maximum value. The same tool electrode can be used, without withdrawal from the work, for coarse machining at first and fine machining under circling movement immediately thereafter.