Abstract: A device which is suitable for collecting cellular and DNA specimens from the upper vagina and lower cervix of a female patient's reproductive tract. The device can be self-administered by the patient and typically includes an expandible, cell-collecting insert disposed in a compressed configuration in a housing which is initially inserted in the patient's vagina. Upon controlled release from the housing, the insert expands into a generally spherical shape to contact the upper vaginal and lower cervical walls and remains in position for a selected period of time, such as eight hours, during which time some of the vaginal and cervical cells become trapped on the insert. After removal of the insert from the vagina, the insert is placed in a suitable specimen container and the cells thereon are tested for abnormal cytology or various medical conditions such as cancer or sexually transmitted diseases.