Patents by Inventor Paul G. Grothaus

Paul G. Grothaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for modulators of metallo-enzyme activity
    Patent number: 6569636
    Abstract: An assay is disclosed for determining whether a test compound modulates the activity of an enzyme having a metallated active site. The assay method employs a comparison of the binding ability of the metallated and unmetallated forms of the enzyme to the test compound.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: May 27, 2003
    Assignee: Hawaii Biotechnology Group, Inc.
    Inventors: Paul G. Grothaus, Dana E. Davis, Sean O'Malley
  • TRANSITION STATE BINDING ASSAY
    Publication number: 20010046663
    Abstract: A method to determine whether a test compound modulates the activity of an enzyme that has a metallated active site, comprising:
    Type: Application
    Filed: May 27, 1999
    Publication date: November 29, 2001
    Inventors: PAUL G. GROTHAUS PH.D, DANA E. DAVIS, SEAN O'MALLEY
  • Process for affinity purification by immunoadsorption in non-aqueous solvent
    Patent number: 5364531
    Abstract: Immunoaffinity purifications are performed using non-aqueous media, desirably, a small amount of an aqueous buffered medium, and, optionally, a surfactant. Hydrophobic ligands can be extracted from samples, immunoaffinity purified and eluted to provide a substantially pure product.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: November 15, 1994
    Assignee: Hawaii Biotechnology Group, Inc.
    Inventors: Gary S. Bignami, Paul G. Grothaus
  • Non-aqueous solvent specific binding protein assays
    Patent number: 5118607
    Abstract: Novel specific protein binding assays are provided employing a solvent system comprising a solvent characterized as hydrophobic, essentially anhydrous and water immiscible. Particularly, lipophilic analytes are shown to be sensitively determined using antibodies in hydrocarbon media, optionally substantially saturated with aqueous buffer and/or comprising an anionic surfactant.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: June 2, 1992
    Assignee: Hawaii Biotechnology Group, Inc.
    Inventors: Gary S. Bignami, Paul G. Grothaus