Patents by Inventor Paul G. Roessler
Paul G. Roessler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220170037Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).Type: ApplicationFiled: February 11, 2022Publication date: June 2, 2022Inventors: Terence A. WALSH, Daniel GACHOTTE, Ann Owens MERLO, Paul G. ROESSLER, James George METZ, Scott BEVAN, Jerry M. KUNER
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Publication number: 20190010510Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).Type: ApplicationFiled: September 24, 2018Publication date: January 10, 2019Inventors: Terence A WALSH, Daniel Gachotte, Ann Owens Merlo, Paul G. Roessler, James Metz, Scott Bevan, Jerry Kuner
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Patent number: 8975061Abstract: The present invention relates to the regulation of a toxin and/or antitoxin genes in a genetically engineered microorganism, such as cyanobacterial or eukaryotic algal strains, in particular for preventing unintentional and/or uncontrolled spread of the microorganisms.Type: GrantFiled: June 28, 2012Date of Patent: March 10, 2015Assignee: ExxonMobil Research and Engineering CompanyInventors: Vincent A. Bielinski, Nicholas Bauman, Kate Lyons Boyd, Srividya Akella, Stanley Bower, Paul G. Roessler
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Patent number: 8945875Abstract: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, ?-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.Type: GrantFiled: June 21, 2013Date of Patent: February 3, 2015Assignee: DSM IP Assets B.V.Inventors: Paul G. Roessler, T. Dave Matthews, Tom M. Ramseier, James G. Metz
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Patent number: 8633002Abstract: Genes and strains of recombinant microorganisms are provided that are engineered to produce fatty alcohols and fatty alcohol derivatives. The organisms can include one, two, three or more transgenes that direct the biosynthesis of one or more fatty alcohols or derivatives. Methods of producing fatty alcohols using transgenic microorganisms are also provided.Type: GrantFiled: August 11, 2010Date of Patent: January 21, 2014Assignee: Synthetic Genomics, Inc.Inventors: Paul G. Roessler, Kevin Watts, Bo Liu
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Publication number: 20130295607Abstract: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, ?-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.Type: ApplicationFiled: June 21, 2013Publication date: November 7, 2013Inventors: Paul G. ROESSLER, T. Dave Matthews, Tom M. Ramseier, James G. Metz
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Publication number: 20130023035Abstract: The present invention relates to the regulation of a toxin and/or antitoxin genes in a genetically engineered microorganism, such as cyanobacterial or eukaryotic algal strains, in particular for preventing unintentional and/or uncontrolled spread of the microorganisms.Type: ApplicationFiled: June 28, 2012Publication date: January 24, 2013Applicant: ExxonMobil Research and Engineering CompanyInventors: Vincent A. Bielinski, Nicholas Bauman, Kate Lyons Boyd, Srividya Akella, Stanley Bower, Paul G. Roessler
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Patent number: 8206984Abstract: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, ?-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.Type: GrantFiled: December 22, 2004Date of Patent: June 26, 2012Assignee: Merck Biosciences CorporationInventors: Paul G. Roessler, T. Dave Matthews, Tom M. Ramseier, James G. Metz
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Publication number: 20110195469Abstract: Genes and strains of recombinant microorganisms are provided that are engineered to produce fatty alcohols and fatty alcohol derivatives. The organisms can include one, two, three or more transgenes that direct the biosynthesis of one or more fatty alcohols or derivatives. Methods of producing fatty alcohols using transgenic microorganisms are also provided.Type: ApplicationFiled: August 11, 2010Publication date: August 11, 2011Applicant: SYNTHETIC GENOMICS, INC.Inventors: PAUL G. ROESSLER, KEVIN WATTS, BO LIU
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Publication number: 20110086390Abstract: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, ?-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.Type: ApplicationFiled: November 9, 2010Publication date: April 14, 2011Applicant: Martek Biosciences CorporationInventors: Paul G. ROESSLER, T. Dave Matthews, Tom M. Ramseier, James G. Metz
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Publication number: 20090158473Abstract: A nucleotide sequence comprising a nucleotide sequence having at least about 90% homology to the sequence of SEQ ID NO:9 or SEQ ID NO:10. Nucleotide sequences interest operatively linked to nucleotide sequence having at least about 90% homology to the sequence of SEQ ID NO:9 or SEQ ID NO:10 are disclosed. Vectors, methods of regulating target expression, methods of providing a cells, plants, and seeds comprising the nucleotide sequence are also disclosed.Type: ApplicationFiled: December 3, 2008Publication date: June 18, 2009Applicant: DOW GLOBAL TECHNOLOGIES INC.Inventors: Paul G. Roessler, Lada Rasochova, Vincent D. Lee
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Patent number: 7001772Abstract: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, ?-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.Type: GrantFiled: April 16, 2002Date of Patent: February 21, 2006Assignee: Martek Biosciences CorporationInventors: Paul G. Roessler, T. Dave Matthews, Tom M. Ramseier, James G. Metz
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Publication number: 20030166207Abstract: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, &agr;-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.Type: ApplicationFiled: April 16, 2002Publication date: September 4, 2003Inventors: Paul G. Roessler, T. Dave Matthews, Tom M. Ramseier, James G. Metz
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Patent number: 5928932Abstract: The present invention relates to a cloned gene which encodes an enzyme, the purified enzyme, and the applications and products resulting from the use of the gene and enzyme. The gene, isolated from Cyclotella cryptica, encodes a multifunctional enzyme that has both UDP-glucose pyrophosphorylase and phosphoglucomutase activities.Type: GrantFiled: April 3, 1996Date of Patent: July 27, 1999Assignee: Midwest Research InstituteInventors: Eric E. Jarvis, Paul G. Roessler
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Patent number: 5661017Abstract: Disclosed is a method to transform chlorophyll C-containing algae which includes introducing a recombinant molecule comprising a nucleic acid molecule encoding a dominant selectable marker operatively linked to an algal regulatory control sequence into a chlorophyll C-containing alga in such a manner that the marker is produced by the alga. In a preferred embodiment the algal regulatory control sequence is derived from a diatom and preferably Cyclotella cryptica. Also disclosed is a chimeric molecule having one or more regulatory control sequences derived from one or more chlorophyll C-containing algae operatively linked to a nucleic acid molecule encoding a selectable marker, an RNA molecule and/or a protein, wherein the nucleic acid molecule does not normally occur with one or more of the regulatory control sequences. Further specifically disclosed are molecules pACCNPT10, pACCNPT4.8 and pACCNPT5.1.Type: GrantFiled: March 15, 1995Date of Patent: August 26, 1997Inventors: Terri Goodman Dunahay, Paul G. Roessler, Eric E. Jarvis
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Patent number: 5559220Abstract: A DNA encoding an acetyl-coenzyme A carboxylase (ACCase) from a photosynthetic organism and functional derivatives thereof which are resistant to inhibition from certain herbicides. This gene can be placed in organisms to increase their fatty acid content or to render them resistant to certain herbicides.Type: GrantFiled: April 7, 1995Date of Patent: September 24, 1996Assignee: Midwest Research InstituteInventors: Paul G. Roessler, John B. Ohlrogge