Patents by Inventor Paul G. Spoors

Paul G. Spoors has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of renin inhibitors
    Patent number: 8242290
    Abstract: Disclosed is a process for the preparation of a tetrahydropyran-di-amine represented by Structural Formula (I): wherein R1 is H or alkyl and E is H or an amine protecting group.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: August 14, 2012
    Assignee: Vitae Pharmaceuticals, Inc.
    Inventors: Paul G. Spoors, Lara S. Kallander, David A. Claremon
  • Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
    Patent number: 7902378
    Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: March 8, 2011
    Assignee: SmithKline Beecham (Cork) Limited
    Inventors: Christopher S. Brook, Wei Chen, Philip C. Dell'Orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
  • Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
    Patent number: 7893100
    Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: February 22, 2011
    Assignee: SB Pharmco Puerto Rico Inc.
    Inventors: Christopher S. Brook, Wei Chen, Philip C. Dell'Orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
  • PROCESS FOR THE PREPARATION OF RENIN INHIBITORS
    Publication number: 20100256400
    Abstract: Disclosed is a process for the preparation of a tetrahydropyran-di-amine represented by Structural Formula (I): wherein R1 is H or alkyl and E is H or an amine protecting group.
    Type: Application
    Filed: September 17, 2008
    Publication date: October 7, 2010
    Inventors: Paul G. Spoors, Lara S. Kallander, David A. Claremon
  • Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
    Patent number: 7759384
    Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: July 20, 2010
    Assignee: SmithKline Beecham (Cork) Limited
    Inventors: Christopher S. Brook, Wei Chen, Philip C. Dell'orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
  • Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
    Patent number: 7750036
    Abstract: The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: July 6, 2010
    Assignee: SB Pharmco Puerto Rico Inc.
    Inventors: Christopher S. Brook, Pingyun Y. Chen, Wei Chen, Qunying Dai, Philip C. Dell'Orco, Clifford S. Labaw, Ann Marie Diederich, Choon K. Oh, Claire Hisler, David H. Igo, Lee M. Katrincic, Li-Jen Ping, Paul G. Spoors, Jun Wang, Christopher Werner
  • Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
    Patent number: 7626041
    Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: December 1, 2009
    Assignee: SmithKline Beecham (Cork) Ltd
    Inventors: Christopher S. Brook, Wei Chen, Philip C. Dell'orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
  • Novel Process and Formulations
    Publication number: 20080268044
    Abstract: The present invention provides for a novel process of making 6-carboxylic acid derivatives of pyrido[2,3-d]pyrimidin-7-one's, as well as a novel process for making 8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]-amino}pyrido[2,3-d]pyrimidin-7(8H)-one, and salts thereof.
    Type: Application
    Filed: November 15, 2006
    Publication date: October 30, 2008
    Inventors: John Robert George Appleby, Philip Blatcher, Ann M. Diederich, Lesley Anne Humphries, Jiri Kasparec, As'ad Abu Khalil, Richard S. Lloyd, Paul G. Spoors, John J. Taggart, Lois E. Vernon
  • CARVEDILOL PHOSPHATE SALTS AND/OR SOLVATES THEREOF, CORRESPONDING COMPOSITIONS, AND/OR METHODS OF TREATMENT
    Publication number: 20080262069
    Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Application
    Filed: June 25, 2007
    Publication date: October 23, 2008
    Inventors: Christopher S. BROOK, Wei Chen, Phillip C. Dell'Orco, Lee M. Katrincic, Ann Marie Louvet, Choon K. Oh, Paul G. Spoors, Christopher Werner
  • Carvedilol phosphate salts and/or solvates thereof, corresponding compositions and/or methods of treatment
    Patent number: 7268156
    Abstract: The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: September 11, 2007
    Assignee: SB Pharmco Puerto Rico Inc.
    Inventors: Christopher S. Brook, Wei Chen, Paul G. Spoors