Patents by Inventor Paul Gadue

Paul Gadue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vector for targeting the human Rosa26 gene
    Patent number: 11078494
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: August 3, 2021
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • STEM CELL GENE TARGETING
    Publication number: 20200071719
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: October 25, 2019
    Publication date: March 5, 2020
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • Mesoderm and definitive endoderm cell populations
    Patent number: 10428308
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 1, 2019
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Gordon M. Keller, Paul Gadue
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20180155681
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 7, 2018
    Inventors: Gordon M. Keller, Paul Gadue
  • STEM CELL GENE TARGETING
    Publication number: 20170298384
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 19, 2017
    Inventors: Gordon M. Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • Mesoderm and definitive endoderm cell populations
    Patent number: 9745553
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: August 29, 2017
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon Keller, Paul Gadue
  • Stem cell gene targeting
    Patent number: 9481896
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 1, 2016
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof
    Patent number: 9476030
    Abstract: Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof are disclosed.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: October 25, 2016
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Paul Gadue, Deborah French, Xin Cheng
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20160186134
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: March 11, 2016
    Publication date: June 30, 2016
    Inventors: Gordon Keller, Paul Gadue
  • Compositions and methods for the generation of platelets and methods of use thereof
    Patent number: 9259443
    Abstract: Compositions and methods for generating platelets and methods of use thereof are disclosed.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: February 16, 2016
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Mortimer Poncz, Mitchell Weiss, Paul Gadue, Deborah French
  • STEM CELL GENE TARGETING
    Publication number: 20160017371
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: May 20, 2015
    Publication date: January 21, 2016
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans J. Fehling
  • MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
    Publication number: 20150315543
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: August 25, 2014
    Publication date: November 5, 2015
    Inventors: Gordon M. Keller, Paul Gadue
  • Targeting the Rosa26 gene in human embryonic stem cells
    Patent number: 9062122
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: June 23, 2015
    Assignee: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans Joerg Fehling
  • Mesoderm and definitive endoderm cell populations
    Patent number: 8815591
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 26, 2014
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Gordon M. Keller, Paul Gadue
  • Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells and Methods of Use Thereof
    Publication number: 20140141509
    Abstract: Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof are disclosed.
    Type: Application
    Filed: December 23, 2013
    Publication date: May 22, 2014
    Inventors: Paul Gadue, Deborah French, Xin Cheng
  • Compositions and Methods for the Generation of Platelets and Methods of Use Thereof
    Publication number: 20140086883
    Abstract: Compositions and methods for generating platelets and methods of use thereof are disclosed.
    Type: Application
    Filed: October 25, 2011
    Publication date: March 27, 2014
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Mortimer Poncz, Mitchell Weiss, Paul Gadue, Deborah French
  • Mesoderm and definitive endoderm cell populations
    Patent number: 8283168
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: October 9, 2012
    Assignee: Mount Sinai School of Medicine
    Inventors: Gordon M. Keller, Paul Gadue
  • Mesoderm and Definitive Endoderm Cell Populations
    Publication number: 20110212061
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
    Type: Application
    Filed: June 23, 2006
    Publication date: September 1, 2011
    Applicant: Mount Sinai School of Medicine of New York University
    Inventors: Gordon M. Keller, Paul Gadue
  • STEM CELL GENE TARGETING
    Publication number: 20100011455
    Abstract: The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
    Type: Application
    Filed: January 18, 2008
    Publication date: January 14, 2010
    Applicant: Mount Sinai School of Medicine of New York Univers
    Inventors: Gordon Keller, Stefan Irion, Herve Luche, Paul Gadue, Hans Joerg Fehling
  • Mesoderm And Definitive Endoderm Cell Populations
    Publication number: 20090181453
    Abstract: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
    Type: Application
    Filed: November 17, 2008
    Publication date: July 16, 2009
    Applicant: Mount Sinai School of Medicine Of New York University
    Inventors: Gordon Keller, Paul Gadue