Patents by Inventor Paul Galardy

Paul Galardy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Semisynthetic protein-based site-directed probes for identification and inhibition of active sites, and methods therefor
    Publication number: 20050277762
    Abstract: A C-terminally modified Ubiquitin (Ub) derivative) ubiquitin vinyl sulfone (UbVS), which is specific for deubiquitinating enzymes (DUBs), was synthesized as an active site directed probe that irreversibly modifies a subset of Ub C-terminal hydrolases (UCHs) and Ub specific processing proteases (UBPs), is provided. [125I]-UbVS modifies 6 of the 17 known and putative yeast deubiquitinating enzymes, namely Yuh1p, Ubp1p, Ubp2p, Ubp6p, Ubp12p and Ubp15p. In mammalian cells, a greater number of polypeptides is labeled, most of which are DUBs. An additional DUB that associates with the mammalian 26S proteasome, novel protein USP14, a mammalian homolog of yeast Ubp6p that is bound to the proteasome, is provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: December 15, 2005
    Inventors: Hidde Ploegh, Huib Ovaa, Anna Borodovsky, Benedikt Kessler, Joris Hemelaar, Paul Galardy, Nagamalleswari Kolli, Tudevin Gan-Erdene, Keith Wilkinson