Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: A system, method, server, and computer readable medium for tracking goal progression. Input is received establishing one or more clients. The one or more clients are individuals receiving treatment or assistance. Each of the one or more clients are assigned to an account. Goals are established for each of the one or more clients. Data associated with each of the one or more clients is compiled as received from one or more monitoring devices. A determination is made where the goals are being met in response to the thresholds for the compiled data. Alerts are automatically communicated in response to the compiled data varying from a threshold to become significant for one of the one or more clients.

Abstract: Selective catalytic reduction (SCR) systems are known and are generally included in the exhaust systems of diesel engines in order to treat the exhaust gases of such engines. Such systems typically involve the introduction of a diesel exhaust fluid (DEF) into exhaust gas flowing in an exhaust passage of an engine. DEF dosing systems are limited by the amounts of DEF that can be delivered without deposits forming on surfaces of the aftertreatment system. An impaction device is dosed with DEF at a first rate based on a set of characteristics of the SCR system. A second set of characteristics, such as an available storage capacity for DEF, is determined based on a set of criteria, such as a decomposition rate of DEF. Based on the second set of characteristics, the DEF dosing rate is changed to a second rate. The dosing rate is reverted to the first rate after a second set of criteria, e.g. a lower threshold of available storage for DEF, are fulfilled.

Abstract: An exhaust mixer apparatus, emissions cleaning module, and a method of manufacturing the exhaust mixer apparatus is provided. The exhaust mixer apparatus comprises an exhaust conduit, a first exhaust mixer and a second exhaust mixer. The exhaust conduit is configured to extend in an elongate direction comprising an inlet and an outlet for transporting exhaust fluid. The first exhaust mixer comprises a plurality of elongate mixing blades each having a length extending in the elongate direction. The elongate mixing blades are connected together along at least part of their lengths and arranged about the elongate direction, each elongate mixing blade comprising an outer edge extending in the elongate direction. The elongate mixing blades are twisted along their lengths such that the outer edge of each elongate mixing blade is rotated about the elongate direction. The exhaust conduit is configured to locate the first exhaust mixer in an upstream location of the exhaust conduit.

Abstract: Selective catalytic reduction (SCR) systems are known and are generally included in the exhaust systems of diesel engines in order to treat the exhaust gases of such engines. Such systems typically involve the introduction of a diesel exhaust fluid (DEF) into exhaust gas flowing in an exhaust passage of an engine. DEF dosing systems are limited by the amounts of DEF that can be delivered without deposits forming on surfaces of the aftertreatment system. An impaction device is dosed with DEF at a first rate based on a set of characteristics of the SCR system. A second set of characteristics, such as an available storage capacity for DEF, is determined based on a set of criteria, such as a decomposition rate of DEF. Based on the second set of characteristics, the DEF dosing rate is changed to a second rate. The dosing rate is reverted to the first rate after a second set of criteria, e.g. a lower threshold of available storage for DEF, are fulfilled.

Abstract: A selective catalytic reduction (SCR) system for treating exhaust gases in an exhaust passage is provided. The system comprises a first catalyst for converting urea to ammonia, the first catalyst being located in the passage and having an upstream face and a downstream face. The upstream face is at a right angle to an axial flow path (A) through the passage. The system further comprises a second catalyst for converting NOx to nitrogen gas and water in the presence of ammonia, with the second catalyst being located in the passage downstream of the first catalyst. A diesel exhaust fluid dosing unit is located upstream of the first catalyst. The dosing unit comprises a nozzle arranged so as to inject DEF directly onto the upstream face of the first catalyst.

Abstract: A transceiver package includes a substrate having an upper surface. An electronic component is mounted to the upper surface of the substrate. A shield encloses the electronic component and shields the electronic component from radiation. The transceiver package further includes an antenna and a dielectric cap. The dielectric cap is interposed between the shield and the antenna, the shield being a ground plane for the antenna.

Abstract: A transceiver package includes a substrate having an upper surface. An electronic component is mounted to the upper surface of the substrate. A shield encloses the electronic component and shields the electronic component from radiation. The transceiver package further includes an antenna and a dielectric cap. The dielectric cap is interposed between the shield and the antenna, the shield being a ground plane for the antenna.