Abstract: A speaker (10) comprises an enclosure (8) defining an internal volume (11); and at least one sound generator (7), the sound generator (7) comprising one or more surfaces defining an air-path conduit (15) through which air operably passes in and out of the internal volume. The sound generator (7) further comprises a plurality of electrodes comprising at least one air-exposed electrode (1, 4) and at least one insulated electrode (2, 3). A voltage source (6) is configured to generate an electrical field between the at least one air-exposed electrode (1, 4) and the at least one insulated electrode (2, 3, 70) to operatively generate a plasma proximal (100) to the plurality of electrodes and within the air-path conduit (15).

Abstract: A speaker (10) comprises an enclosure (8) defining an internal volume (11); and at least one sound generator (7), the sound generator (7) comprising one or more surfaces defining an air-path conduit (15) through which air operably passes in and out of the internal volume. The sound generator (7) further comprises a plurality of electrodes comprising at least one air-exposed electrode (1, 4) and at least one insulated electrode (2, 3). A voltage source (6) is configured to generate an electrical field between the at least one air-exposed electrode (1, 4) and the at least one insulated electrode (2, 3, 70) to operatively generate a plasma proximal (100) to the plurality of electrodes and within the air-path conduit (15).

Abstract: A method and apparatus for generating an image to encode digital data to be computer readable is disclosed. The method and apparatus defines a spatial reference object configuration within an encoding region; defines a shape and size of the encoding region by defining a boundary around the spatial reference object configuration; determines relative spatial properties for a plurality of coding objects to be displayed in the image based on the digital data and the spatial reference object configuration; and generates an image of the coding objects spatially arranged in the encoding region around the spatial reference object configuration in accordance with the determined spatial properties, wherein the spatial reference object configuration is distinctive compared to the coding objects. Also a method and apparatus for decoding digital data in an image is disclosed.

Abstract: A computer apparatus and method for determining score data for a location, comprising receiving a vote input by a user on a visit to a location from a user's mobile device, the vote input representing a vote for the location and including an identifier for the user's mobile device or the user and information identifying the location; retrieving from storage score data for the user and score data for the location, the score data for the user being a derivative of previous vote inputs for locations and the score data for the location being a derivative of previous vote inputs by users for the location; and determining score data for the visit dependent upon the score data for the user and the score data for the location; wherein the score data for the location is modified dependent upon the determined score data for the visit.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II): Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression.

Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their uses in inhibiting ?-amyloid peptide (?-AP) production.

Abstract: The present invention provides 4-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-[1,5-?]-pyrazolo-1,3,5-triazine benzenesulfonate salt and a crystalline polymorph thereof. Further provided are pharmaceutical compositions containing the salt and methods of treating CRF-related disorders using said salt.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: 1

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.