Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: A composite I-truss is provided, that comprises a pair of top and bottom flanges and an extending intermediate web having a first end secured to the first flange and a second end secured to the second flange. Each flange comprises one or more longitudinal beams secured to the flange connectors. The web comprises at least a pair of flange connectors extending away from the flange and toward the web. The web comprises a plurality of linking struts located at a plurality of longitudinal positions along a length of the I-truss and connecting the flange connectors of the first flange to the flange connectors of the second flange.

Abstract: An input N-plexer filter stage is susceptible to receive surge energy via an input conductor, when the surge energy occurs. A high-pass filter included in a diplexer filter stage applies a radio frequency (RF) signal in a signal path between the input N-plexer filter stage and an output of a Data Over Cable Service Interface Specification (DOCSIS) transmitter stage. A low-pass filter included in the diplexer filter stage couples a surge suppressing threshold device to the signal path to dissipate the surge energy in the surge suppressing threshold device, when the surge energy occurs. The low-pass filter has a cut-off frequency that is lower than a normal operation frequency range of the RF signal. The low-pass filter isolates the surge suppressing threshold device from the signal path in normal operation frequency range of the RF signal, when no surge energy is applied.

Abstract: A composite I-truss is provided, that comprises a pair of top and bottom flanges and an extending intermediate web having a first end secured to the first flange and a second end secured to the second flange. Each flange comprises one or more longitudinal beams secured to the flange connectors. The web comprises at least a pair of flange connectors extending away from the flange and toward the web. The web comprises a plurality of linking struts located at a plurality of longitudinal positions along a length of the I-truss and connecting the flange connectors of the first flange to the flange connectors of the second flange.

Abstract: The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions.

Abstract: The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions.

Abstract: The invention concerns a microscopic system with atomic force, comprising a probe tip placed on one end of a lever arm (2), oscillating means (1) adapted to oscillate said probe tip substantially based on the fundamental frequency of said lever arm, said system including control means (7) for controlling said oscillating means to vary the oscillation frequency of said tip based on a plurality of harmonics of said lever arm. The invention is characterized in that said control means comprise an input receiving a parameter representing an operating threshold of said system, to vary the oscillation frequency of said tip based on at least one harmonic of said lever arm when said signal corresponds to a state of said system higher than said operating threshold.

Abstract: An electronic game features captivating animations and rich selection criteria while offering the simplicity that makes the popularity of legacy games such as roulette, wheel of fortune and multi-line fruit machines casino games. One implementation of the present electronic game is configured as a 2D game tailored for slot machines. Solid 3D variants of the game extending beyond the established video slot machine form-factor are also described.

Abstract: The invention concerns a microscopic system with atomic force, comprising a probe tip placed on one end of a lever arm (2), oscillating means (1) a to oscillate said probe tip substantially based on the fundamental frequency of said lever arm, said system including control means (7) for controlling said oscillating mean to vary the oscillation frequency of said tip based on a plurality of harmonics of said lever arm. The invention is characterized in that said control means comprise an input receiving a parameter representing an operating threshold of said system, to vary the oscillation frequency of said tip based on at least one harmonic of said lever arm when said signal corresponds to a state of said system higher than said operating threshold.

Abstract: An electronic game features captivating animations and rich selection criteria while offering the simplicity that makes the popularity of legacy games such as roulette, wheel of fortune and multi-line fruit machines casino games. One implementation of the present electronic game is configured as a 2D game tailored for slot machines. Solid 3D variants of the game extending beyond the established video slot machine form-factor are also described.

Abstract: A computer case having at least one 31/2" drive housing which can be removably mounted within the case. Each 31/2" drive housing has one or more (typically, two) channels. A 31/2" drive is slidably insertable within each channel. A plurality (normally, as many as four) 31/2 drive housings are removably mountable at different locations within the case via quick release connectors provided at different locations within the case. A "U" shaped mounting bracket captures each 31/2" drive. The bracket has two opposed legs, with one or more inwardly projecting pins on each leg. The pins slide into apertures located in the opposed sides of industry standard 31/2" drives. A one-piece backplane with quick release connectors is easily removed and replaced by adjacent a cutout provided in an outer wall of the case. A series of cutouts are provided in the backplane. Each cutout is positioned to align with a connector on a motherboard mounted in the case, when the backplane is in place adjacent the case outer wall cutout.

Abstract: A circuit arrangement for reducing access time to information contained in a memory system that includes a register for collecting the information contained in the memory system. The register operates as a flip-flop and is composed of a first inverter, an AND gate and a second inverter. The input of the first inverter is connected to receive the information bits read in a memory block. The AND gate includes two inputs, one of which is connected to the output of the first inverter. The other input receives, at the beginning of the memory reading cycle, an initialization signal for positioning the flip-flop in a given state. The output of the AND gate is connected to the second inverter which has its output connected, in turn, to the input receiving information read from the memory system.

Abstract: A device is provided for automatically determining the storage capacity of a data processing or transmission system and signalling when the storage capacity is inadequate to handle an incoming address. The store includes a plurality of storage fractions made up of storage modules adopted to be plugged into a printed circuit board having a conductor pattern thereon and connector locations disposed along the conductor pattern. The modules may be plugged into the circuit board and a full storage fraction is established when electrical continuity is established along the whole length of a conductor which connects all of the location localities assigned to a storage fraction. The conductor pattern is interrupted at the connection localities of the modules of one and the same storage fraction.