Abstract: A rupture disk (20), along with associated methods, is disclosed. More particularly, a miniaturized rupture disk is disclosed, comprising a transition area (23) configured to determine a pressure at which the rupture able portion will rupture. A method for forming a rupture disk is also disclosed, wherein a radius (R) of a transition area is configured to set the burst pressure of the rupture disk. A rupture disk having an indent at its apex (24) and a circular line of weakness configured to improve opening performance is also disclosed. Additionally, a method of relieving pressure in a pressurized system is disclosed, wherein a set of rupture disks is provided, wherein each rupture disk in the set has a different radius of transition area. A rupture disk may be selected from the set and installed based on a burst pressure set by the radius of transition area.

Abstract: A rupture disk (200) having a line of weakness (235) is disclosed. In one embodiment, a frustum-shaped rupture disk has a shear-scored line of weakness located in one or more of a central truncated portion (220), an angled frustum portion (230), a flange portion (210), and in the areas of transition between a flange portion and an angled frustum portion, and between an angled frustum portion and a central truncated portion. In another embodiment, a frustum-shaped rupture disk has an angled frustum portion, with a line of weakness in the angled frustum portion. A stiffening member may be provided to stiffen a central truncated portion of a frustum-shaped rupture disk.

Abstract: A hinge assembly for a rupture disk is disclosed. More particularly, a hinge assembly is disclosed having a first hinge member with a flange body and a collapsible hinge, and a second hinge member with a platform hinge, wherein the collapsible hinge is configured to be positioned between the platform hinge and a rupture disk. A rupture disk hinge is also disclosed, having a flange body and a collapsible hinge extending from the flange body. The collapsible hinge may have an approach extending from the flange body, a platform extending from the approach, and a lip extending from the platform. A rupture disk hinge also is disclosed having a hinge extension that extends along a diameter of a flange body across a central fluid flow path.

Abstract: A rupture disk (200) having a line of weakness (235) is disclosed. In one embodiment, a frustum-shaped rupture disk has a shear-scored line of weakness located in one or more of a central truncated portion (220), an angled frustum portion (230), a flange portion (210), and in the areas of transition between a flange portion and an angled frustum portion, and between an angled frustum portion and a central truncated portion. In another embodiment, a frustum-shaped rupture disk has an angled frustum portion, with a line of weakness in the angled frustum portion. A stiffening member may be provided to stiffen a central truncated portion of a frustum-shaped rupture disk.

Abstract: A system and associated methods of quality control for a pressure relief device are disclosed. More specifically, a system and method including one or more of non-destructive dimensional or visual verification, unique identification (e.g., serialization), and image capture of a pressure relief device or a constituent component of such a device are disclosed. A system and method are disclosed in which a checked physical attribute of a pressure relief device, or component thereof, is compared against a statistically expected attribute to determine whether the device or component is suitable for further manufacture or delivery to a customer.

Abstract: A system and associated methods of quality control for a pressure relief device are disclosed. More specifically, a system and method including one or more of non-destructive dimensional or visual verification, unique identification (e.g., serialization), and image capture of a pressure relief device or a constituent component of such a device are disclosed. A system and method are disclosed in which a checked physical attribute of a pressure relief device, or component thereof, is compared against a statistically expected attribute to determine whether the device or component is suitable for further manufacture or delivery to a customer.

Abstract: A hinge assembly for a rupture disk is disclosed. More particularly, a hinge assembly is disclosed having a first hinge member with a flange body and a collapsible hinge, and a second hinge member with a platform hinge, wherein the collapsible hinge is configured to be positioned between the platform hinge and a rupture disk. A rupture disk hinge is also disclosed, having a flange body and a collapsible hinge extending from the flange body. The collapsible hinge may have an approach extending from the flange body, a platform extending from the approach, and a lip extending from the platform. A rupture disk hinge also is disclosed having a hinge extension that extends along a diameter of a flange body across a central fluid flow path.

Abstract: A rupture disk (20), along with associated methods, is disclosed. More particularly, a miniaturized rupture disk is disclosed, comprising a transition area (23) configured to determine a pressure at which the rupture able portion will rupture. A method for forming a rupture disk is also disclosed, wherein a radius (R) of a transition area is configured to set the burst pressure of the rupture disk. A rupture disk having an indent at its apex (24) and a circular line of weakness configured to improve opening performance is also disclosed. Additionally, a method of relieving pressure in a pressurized system is disclosed, wherein a set of rupture disks is provided, wherein each rupture disk in the set has a different radius of transition area. A rupture disk may be selected from the set and installed based on a burst pressure set by the radius of transition area.

Abstract: The present invention relates to compositions for transdermal administration of a therapeutic agent for providing a systemic therapeutic effect. In particular, the invention relates to spreadable compositions, or compositions which may be solid at a temperature of about 25° C. or less and have a softening point of not higher than 35° C., wherein transdermal administration of the therapeutic agent may be either rapid or sustained.

Abstract: The present invention relates to compositions and applicator devices for providing accurate and localized administration of pharmaceutical compositions containing therapeutic agents to the skin. In particular, the invention relates to compositions which are solid at a temperature of about 250 C or less, and which soften upon continuous contact with the skin of a patient. The present invention allows a user to administer precise doses of a therapeutic agent by highly localized application of the composition to a desired skin region, without contacting surrounding skin regions, or the user's hand.

Abstract: The present invention provides pharmaceutical compositions for treating a paediatric mammal, the compositions comprising a therapeutic agent and a pharmaceutically acceptable carrier, the composition being suitable for topical application resulting in transdermal administration of the therapeutic agent and a systemic therapeutic effect. The invention also provides relates uses of the compositions, applicators and kits.

Abstract: A confectionery product for delivering at least one pharmaceutically active agent which includes a hard outer shell and a core comprised of a core material which is or forms a liquid-like to a gel-like substance in the oral cavity and is capable of delivering pharmaceutically active agents to infected and/or irritated tissues of the throat.