Patents by Inventor Paul Golueke
Paul Golueke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120076761Abstract: Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.Type: ApplicationFiled: October 1, 2010Publication date: March 29, 2012Applicant: University of MassachusettsInventors: Steven Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce De Leon, D. Joseph Jerry
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Publication number: 20090092588Abstract: Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.Type: ApplicationFiled: September 26, 2006Publication date: April 9, 2009Inventors: Steven Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce De Leon, D. Joseph Jerry
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Patent number: 7291764Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: GrantFiled: September 13, 1999Date of Patent: November 6, 2007Assignee: University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at AmherstInventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke
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Publication number: 20070067861Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: ApplicationFiled: November 22, 2006Publication date: March 22, 2007Inventors: Steven Stice, James Robl, Jose Cibelli, Paul Golueke
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Publication number: 20060294603Abstract: The invention is directed in part to totipotent cells that have one or more artificial chromosomes; processes for producing such cells; processes for using such cells (e.g., nuclear transfer); transgenic embryos and transgenic animals cloned from such cells; and processes for producing such embryos and animals.Type: ApplicationFiled: February 21, 2002Publication date: December 28, 2006Inventors: Eric Forsberg, Kelly Mallon, Paul Golueke, Michael Bishop
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Publication number: 20060021070Abstract: Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNA is inserted into the subject CICM cells and cell lines so as produce transgenic CICM cell which are introduced into non-human fertilized embryos to produce transgenic chimeric embryos. The transgenic chimeric embryos are transferred into recipient females where they are permitted to develop into transgenic chimeric fetuses. Recipient females give birth to transgenic chimeric animals which are capable of transmitting the heterologous DNA to their progeny. Transgenic CICM cells are also used to produce cloned transgenic embryos, fetuses and offspring.Type: ApplicationFiled: December 28, 2004Publication date: January 26, 2006Applicant: University of Massachusetts, A public Institution of Higher Education of the Commonwealth of MAInventors: Steven Stice, Jose Cibelli, James Robl, Paul Golueke, F. Leon, D. Jerry
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Publication number: 20050108785Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: ApplicationFiled: September 2, 2004Publication date: May 19, 2005Applicant: University of Massachusetts, Amherst CampusInventors: Steven Stice, Jose Cibelli, James Robl, Paul Golueke, F. de Leon, D. Jerry
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Publication number: 20040194159Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: ApplicationFiled: April 2, 2004Publication date: September 30, 2004Applicant: University of MassachusettsInventors: Steven L. Stice, James M. Robl, Jose Cibelli, Paul Golueke
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Publication number: 20040120934Abstract: Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.Type: ApplicationFiled: March 21, 2003Publication date: June 24, 2004Applicant: Advanced Cell Technology, Inc.Inventors: Steven Stice, Jose Cibelli, James M. Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry
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Publication number: 20020035737Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: ApplicationFiled: May 1, 2001Publication date: March 21, 2002Applicant: University of MassachusettsInventors: Steven L. Stice, James M. Robl, Jose Cibelli, Paul Golueke
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Publication number: 20020010949Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: ApplicationFiled: April 10, 2001Publication date: January 24, 2002Applicant: University of Massachusetts, Amherst CampusInventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry
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Patent number: 6235969Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: GrantFiled: July 3, 1997Date of Patent: May 22, 2001Assignee: University of MassachusettsInventors: Steven L. Stice, James M. Robl, Jose Cibelli, Paul Golueke
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Patent number: 6235970Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: GrantFiled: September 22, 1997Date of Patent: May 22, 2001Assignee: University of Massachusetts, Amherst CampusInventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry
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Patent number: 6215041Abstract: Methods and cell lines for cloning bovine embryos and offspring are provided. The resultant embryos or offspring are especially useful for the expression of desired heterologous DNAs.Type: GrantFiled: January 8, 1998Date of Patent: April 10, 2001Assignee: University of MMassachusettsInventors: Steven L. Stice, Jose Cibelli, James M. Robl, Paul Golueke, D. Joseph Jerry
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Patent number: 5994619Abstract: Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNA is inserted into the subject CICM cells and cell lines so as produce transgenic CICM cell which are introduced into non-human fertilized embryos to produce transgenic chimeric embryos. The transgenic chimeric embryos are transferred into recipient females where they are permitted to develop into transgenic chimeric fetuses. Recipient females give birth to transgenic chimeric animals which are capable of transmitting the heterologous DNA to their progeny. Transgenic CICM cells are also used to produce cloned transgenic embryos, fetuses and offspring.Type: GrantFiled: December 16, 1996Date of Patent: November 30, 1999Assignee: University of Massachusetts, A Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst CampusInventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry
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Patent number: 5945577Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.Type: GrantFiled: January 10, 1997Date of Patent: August 31, 1999Assignee: University of Massachusetts as represented by its Amherst CampusInventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry