Abstract: Provided herein are compounds of Formula (I?), Formula (I?), Formula (I), Formula (II?), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are methods, uses, and kits involving the disclosed compounds and pharmaceutical compositions thereof for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers), inflammatory diseases (e.g., fibrosis), autoimmune diseases (e.g., sclerosis)) in a subject. Provided are methods of inhibiting the activity of a transcription factor (e.g., TEAD, such as TEAD1, TEAD2, TEAD3, TEAD4) and/or inhibiting the transcription of a gene (e.g., a gene controlled or regulated by a transcription factor (e.g., TEAD)) in a subject.

Abstract: Devices, systems, and methods for coupling tubing to a fluid reservoir to provide liquid to an endoscope system. A manifold for coupling to a fluid reservoir and a tubing assembly may include first portion interfacing with an interior of the fluid reservoir and a second portion configured to interface with tubing to be fluidly coupled to the interior of the reservoir. The first portion may include one or more openings to allow gas to pass into the fluid reservoir and liquid to pass out of the fluid reservoir. The second portion may include one or more ports for connecting to tubing that brings gas to the fluid reservoir and receives liquid from the fluid reservoir. The manifold may include a valve that selectively allows gas to pass into the fluid reservoir.

Abstract: The present invention provides novel compounds of Formulae (I?) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: An ophthalmic surgical laser system includes a laser beam delivery system having multiple moving components for scanning a laser focal spot in a target eye tissue, where the motors that actuate some of the moving components are equipped with respective digital encoders that measure actual motor positions. A controller controls the laser beam delivery system to perform a treatment scan, while recording the actual motor positions from the encoders. Using the actual motor positions and a calibration relationship between actual motor positions and delivered laser focal spot positions in a target tissue, a laser cutting pattern is digitally reconstructed, which represents the incisions actually achieved by the treatment scan. The reconstructed laser cutting pattern may be visually inspected and further analyzed, e.g. to compare it to the intended laser cutting pattern used to execute the treatment scan, to calculate the achieved refractive correction, or to simulate tissue resetting.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: An electrical connector includes a differential signal pair. A portion of each terminal is disposed in an insulative housing and an electrically conductive shield extends around at least a portion of the terminals and a least a portion of the housing. The housing may have a lower surface and a projection extending downward from the lower surface between a portion of a vertical section of each of the terminals. The terminals may have an angled section including a vertical portion having a first width, an angled portion narrower than the vertical portion, and a horizontal portion narrower than the angled portion. The housing may have a housing mating component spaced from a housing body component and aligned with but spaced from the terminals. The terminals may have a planar termination section with a first portion wider than a second portion.

Abstract: A roof vent assembly may include a vent tube, a vent cap, an air plate and one or more airflow extension members. The airflow extension members may extend outward beyond the periphery of the air plate to create external air plenums. The roof vent assembly may be operable to draw air from the external air plenums under a roof membrane, into an internal air plenum defined by the air plate, through the vent tube and out of the vent cap to remove moisture from the roof.

Abstract: In order to confirm that a telephone call received by a network termination on a first connection is from a trusted party, the called party connects over a second, independent, connection 7 to a server associated with the trusted party and shares a code with the server. That code is then transmitted over the first connection and, if the connection is genuine, it is intercepted by the server which generates a message over the second connection confirming that the code has been matched. This gives the called party assurance that the call is from a party associated with the trusted server. If a rogue caller attempts to call the termination, the called party's transmission of the shared code will be routed over the caller's connection, which is not associated with the trusted server, so no match will be identified by the server and no confirmation is returned over the second connection.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: According to one embodiment, a method comprises automatically uploading device information from a first network device in a first operating state to a second network device in response to an event, such as an initial power up. The second network device is part of the cloud, and thus, providing cloud-based services. Subsequent to the uploading of the device information, the first network device receives information controlling the operation of the first network device based on the device information.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: A motor position compensation method for an ophthalmic surgical laser system employs a deep artificial neural network to characterize motor following errors of the motors of the system. The artificial neural network is trained using a large number of commanded motor positions and corresponding measured actual motor positions (measured by encoders associated with the motors) as training data, to obtain a trained artificial neural network that can predict the actual motor position for any commanded motor position. Before executing a treatment scan, the original commanded motor positions calculated from the intended scan pattern are inputted to the trained artificial neural network to predict the actual motor positions, and the predicted actual motor positions are used to adjust the original commanded motor positions. The adjusted commanded motor positions are then used to perform the treatment scan, which produces an actual scan pattern that more closely match the intended scan pattern.

Abstract: An ophthalmic surgical laser system includes a laser beam delivery system having multiple moving components for scanning a laser focal spot in a target eye tissue, where the motors that actuate some of the moving components are equipped with respective digital encoders that measure actual motor positions. A controller controls the laser beam delivery system to perform a treatment scan, while recording the actual motor positions from the encoders. Using the actual motor positions and a calibration relationship between actual motor positions and delivered laser focal spot positions in a target tissue, a laser cutting pattern is digitally reconstructed, which represents the incisions actually achieved by the treatment scan. The reconstructed laser cutting pattern may be visually inspected and further analyzed, e.g. to compare it to the intended laser cutting pattern used to execute the treatment scan, to calculate the achieved refractive correction, or to simulate tissue resetting.

Abstract: An agricultural data collection framework is provided in a system and method for tracking and managing livestock, and for analyzing animal conditions such as health, growth, nutrition, and behavior. The framework uses ultra-high frequency interrogation of RFID tags to collect individual animal data across multiple geographical locations, and incorporates artificial intelligence techniques to develop machine learning base models for statistical process controls around each animal for evaluating the animal condition. The framework provides a determination of normality at an individual animal basis or for a specific location, and generates alerts, predictions, and a targeted processing or application schedule for prioritizing and delivering resources when intervention is needed.

Abstract: An electrical connector includes a differential signal pair. A portion of each terminal is disposed in an insulative housing and an electrically conductive shield extends around at least a portion of the terminals and a least a portion of the housing. The housing may have a lower surface and a projection extending downward from the lower surface between a portion of a vertical section of each of the terminals. The terminals may have an angled section including a vertical portion having a first width, an angled portion narrower than the vertical portion, and a horizontal portion narrower than the angled portion. The housing may have a housing mating component spaced from a housing body component and aligned with but spaced from the terminals. The terminals may have a planar termination section with a first portion wider than a second portion.

Abstract: In order to confirm that a telephone call received by a network termination on a first connection is from a trusted party, the called party connects over a second, independent, connection 7 to a server associated with the trusted party and shares a code with the server. That code is then transmitted over the first connection and, if the connection is genuine, it is intercepted by the server which generates a message over the second connection confirming that the code has been matched. This gives the called party assurance that the call is from a party associated with the trusted server. If a rogue caller attempts to call the termination, the called party's transmission of the shared code will be routed over the caller's connection, which is not associated with the trusted server, so no match will be identified by the server and no confirmation is returned over the second connection.