Abstract: Novel benzothiazolyl thienopyridine compounds are provided and pharmaceutical compositions comprising benzothiazolyl thienopyridine compounds. The benzothiazolyl thienopyridine compounds are capable of inhibiting the interactions between vascular endothelial growth factor (VEGF) and heparan sulfate glycosaminoglycans (HS-GAGs), and are useful for prevention or treatment of diseases and disorders such as inflammation, autoimmune diseases and cancer.

Abstract: Apparatus for detecting a flammable atmosphere within a compressor during operation thereof is provided. The apparatus comprising a test chamber which is selectably connected between the compressor and an exhaust duct of the compressor using isolation means; an ignition device which is located within the test chamber for igniting any flammable fluid mixture present therein; and sensing means associated with the test chamber for monitoring a parameter indicative of combustion within the test chamber and for outputting a signal indicative of the parameter to a controller.

Abstract: The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) interactions with effector cell adhesion molecules (ECAM) are useful for treating diseases and disorders mediated by GAG-ECAMs interactions, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.

Abstract: The present invention provides pharmaceutical compositions comprising quinazolinecarboxamide derivative, and certain novel quinazolinecarboxamide derivatives capable of inhibiting heparan sulfate-glycosaminoglycan (HS-GAGs) interactions with L-selectin, and useful in the prevention or treatment of various diseases, disorders and conditions mediated by HS-GAGs, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.

Abstract: The present invention relates to a method of screening for small organic molecules that directly inhibit the interaction of glycosaminoglycans (GAGs) with GAG-binding viral proteins (GBVPs), which comprises contacting a GAG with an GBVP in the presence of at least one candidate compound; and measuring the amount of the GAG bound to the GBVP or the amount of the GBVP bound to the GAG, wherein a significant decrease in GAG-GBVP binding as compared to GAG-GBVP binding in the absence of the candidate compound, identifies said compound as inhibitor of the GAG-GBVP interaction. The invention further provides pharmaceutical compositions comprising certain 2-thioxo-thiazolidinone derivatives, particularly useful against virus infections.

Abstract: The present invention relates to methods for screening small organic compounds capable of inhibiting the interactions of glycosaminoglycans with effector cell adhesion molecules. Specifically, the present invention provides a method for screening of small organic compounds, the compounds inhibit the interaction of heparin with L-selectin or P-selectin. The compounds identified by the methods of the invention are useful for treating inflammatory disorders, autoimmune diseases and cancer.

Abstract: The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) interactions with effector cell adhesion molecules (ECAM) are useful for treating diseases and disorders mediated by GAG-ECAMs interactions, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.

Abstract: A system and method for achieving self-regulated voltage division among multiple serially stacked voltage planes. The system of the present invention is incorporated within a source voltage plane having a source supply node for supplying current and a source ground node for sinking current supplied therefrom. An intermediate voltage supply node is coupled between the source supply voltage node and the source ground node for dividing the source voltage plane into a plurality of intermediate voltage planes. The self-regulated voltage divider of the present invention includes a first capacitor and a second capacitor that are each controllably coupled between either the source supply voltage node and the intermediate voltage supply node, or between the intermediate voltage supply node and the source ground node, such that a voltage level balance is achieved among the intermediate voltage planes.

Abstract: A programmable delay element having a fine delay circuit with fractional units of delay. The fine delay circuit has a fine delay circuit with a plurality of selectable delay paths, each delay path having an associated delay interval. The fine delay element is electrically-coupled to a data terminal for receiving and delaying an input signal. A control circuit is electrically-coupled to the fine delay circuit to select the delay path for the input signal. In a further aspect of the invention, the fine delay circuit is electrically-coupled to a coarse delay circuit having a plurality of selectable delay blocks in a repetitive block configuration. The coarse delay circuit is electrically-coupled to a second data terminal for receiving and inserting a second signal through said fine delay circuit. The control circuit is electrically-coupled to the selective delay path of the fine delay circuit and the coarse delay circuit such that either a fine delay, a coarse delay, or a coarse and a fine delay can be selected.

Abstract: In the laying of communications cables in the interior of pipes, in which hot substances are conveyed, it is important to provide communications cables of this type with long-term protection against the surrounding aggressive heat. The communications cable is not laid directly in contact with this aggressive hot environment in that at least one continuous cavity is arranged around the cable core of the said communications cable, which cavity is sealed by a sleeve. In order to be able to extract heat which inevitably diffuses over time from the hot environment into the said cavity, a medium is advantageously conveyed through the cavity. Only in this way is it possible to maintain a constant temperature around the cable core on a long-term basis and to accordingly obtain a long-life communications cable laid, for example, in district heating pipes.

Abstract: An apparatus comprising a clock for providing a clock signal, means for providing a delayed version of the clock signal, two transparent latches having clock inputs controlled by opposite polarities of the delayed clock signal, a multiplexer having (i) inputs fed by outputs of the latches, and (ii) a select input fed by the clock signal, and means for providing a select signal for selecting the latch whose clock is inactive. Preferably, each of the latches has a scan input gate and a scan output gate, and the scan output of the first latch is applied to the scan input of the second latch to form a scannable latch pair. Also, preferably, the apparatus further comprises a data port for applying data to the first and second latches, and an exclusive OR gate at the data port, whereby the apparatus produces a gated clock signal. Also disclosed is a method of operating this apparatus.

Abstract: Rapid set-up is achieved in a programmable delay element having identical pairs of positionally corresponding delay stages in parallel arrays. The pairs of delay elements include identical arrangements of circuit elements and are replicable in a step-and-repeat fashion to simplify delay element manufacture for any arbitrary maximum delay time to be provided. Delay stages of the delay element are comprised of multiplexers. Outputs of respective delay stages are simultaneously stored as a signal transition is propagated through the delay stages in a first order to program the delay element. Thereafter, signals are propagated through selected delay stages in a second order controlled by the simultaneously stored outputs of respective delay stages during the propagation of the signal transition.

Abstract: An LSSD MUX D flip flop includes a multiplexer, a master latch L1 and a slave latch L2. The inputs to the multiplexer are functional data D, scan data I, and the control is scan enable SE. The L1 master latch receives its input from the output of the multiplexer and is clocked by the NAND of a -FLUSH (-A CLOCK) with an +EdgeClock (-C CLOCK.) The L2 slave latch receives its data input from the output of the L1 master latch and is clocked with the AND of -FREEZE (B CLOCK) and +EdgeClock. The output of the flip flop is the output of the L2 slave latch. This flip flop structure supports edge sensitive, level sensitive, functional, scan, freeze, flush, and test operations.

Abstract: A latch comprises first and second NFETs and a first inverter. Data is applied without inversion to the gate of the first NFET and via the first inverter to the gate of the second NFET. A third NFET has a drain connected to the sources of the first and second NFETs. A clock is applied to the gate of the third NFET. Thus, there is only one NFET subject to the constant switching the clock, and therefore the constant power dissipation caused by the clock. To latch the data from the first and second NFETS, first and second inverters are connected in paralle with each other such that the output of each inverter is connected to the input of the other inverter. The input of one of the inverters is connected to the drain of the first NFET and the input of the other inverter is connected to the drain of the second NFET. A second stage of latching is also disclosed.

Abstract: A two-port memory cell design which permits simultaneous reading and writing of cells which are on the same wordline but on different Bit Select lines without increase in Read Access Time, and while maintaining memory functionality at low voltages. The memory cell uses a standard 6 transistor design to provide a differential read for fast access plus another three transistors are added to each cell to provide a means of differentially writing the cell and de-gating the write if the bit-select is not active. This cell design has applicability to multi-port memories as well.