Patents by Inventor Paul Grimaldi

Paul Grimaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stimulating the differentiation of preadipocytic cells and therapies based thereon
    Patent number: 6248791
    Abstract: The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-&agr; receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: June 19, 2001
    Assignee: Centre International de Recherches Dermatologiques Galderma
    Inventors: Gérard Ailhaud, Paul Grimaldi, Irina Safonova, Braham Shroot, Uwe Reichert
  • Stimulating the differentiation of preadipocytic cells and therapies based thereon
    Patent number: 5854292
    Abstract: The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-.alpha. receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: December 29, 1998
    Assignee: Centre International De Recherches Dermatologiques Galderma
    Inventors: Gerard Ailhaud, Paul Grimaldi, Irina Safonova, Braham Shroot, Uwe Reichert
  • Stimulating the differentiation of predipocytic cells and therapies based thereon
    Patent number: 5827897
    Abstract: The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-.alpha. receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: October 27, 1998
    Assignee: Centre International De Recherches Dermatologiques Galderma
    Inventors: Gerald Ailhaud, Paul Grimaldi, Irina Safonova, Braham Shroot, Uwe Reichert
  • Stimulating the differentiation of preadipocytic cells and therapies based thereon
    Patent number: 5728739
    Abstract: The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-.alpha. receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: March 17, 1998
    Assignee: Centre International De Recherches Dermatologiques Galderma
    Inventors: Gerard Ailhaud, Paul Grimaldi, Irina Safonova, Braham Shroot, Uwe Reichert