Patents by Inventor Paul Grinberg

Paul Grinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11951156
    Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-? ligand trap, and methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-? signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-? ligand trap to reduce right ventricular systolic pressure in a subject.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: April 9, 2024
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ACCELERON PHARMA, INC.
    Inventors: Paul B. Yu, Asya Grinberg, Dianne S. Sako, Roselyne Castonguay, Rita Steeves, Ravindra Kumar
  • Publication number: 20240082583
    Abstract: A medical device is configured to sense a cardiac signal that includes far field ventricular event signals and determine a ventricular activity metric from the sensed cardiac signal. The ventricular activity metric may be representative of a ventricular rate or an atrioventricular time interval. The medical device is configured to determine an atrioventricular synchrony metric based on the ventricular activity metric and generate an output based on the atrioventricular synchrony metric. The device may include a memory configured to store data corresponding to the atrioventricular synchrony metric.
    Type: Application
    Filed: November 13, 2023
    Publication date: March 14, 2024
    Inventors: Vincent P. GANION, Yanina GRINBERG, Paul R. SOLHEIM
  • Patent number: 10078888
    Abstract: Aspects of the disclosure are directed toward systems and methods for combining aspects of a plurality of indexed images taken at different focus distances in order to generate a final image having objects at a variety of depths remain in focus. High frequency frames associated with each of the plurality of images can be generated, each high frequency frame being representative of the high frequency content of the associated image. The high frequency content in a plurality of regions in each of the plurality of high frequency frames can be analyzed to determine which regions include valid high frequency content. A final image can be generated comprising, for each of the plurality of regions, image data from the image having like index as the high frequency frame having the greatest valid high frequency content in that region.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: September 18, 2018
    Assignee: Fluke Corporation
    Inventors: Jamie Rhead, Brian R. Gattman, Paul Grinberg, Matthew H. Skorina, Eugene Skobov
  • Publication number: 20170206642
    Abstract: Aspects of the disclosure are directed toward systems and methods for combining aspects of a plurality of indexed images taken at different focus distances in order to generate a final image having objects at a variety of depths remain in focus. High frequency frames associated with each of the plurality of images can be generated, each high frequency frame being representative of the high frequency content of the associated image. The high frequency content in a plurality of regions in each of the plurality of high frequency frames can be analyzed to determine which regions include valid high frequency content. A final image can be generated comprising, for each of the plurality of regions, image data from the image having like index as the high frequency frame having the greatest valid high frequency content in that region.
    Type: Application
    Filed: February 12, 2016
    Publication date: July 20, 2017
    Inventors: Jamie Rhead, Brian R. Gattman, Paul Grinberg, Matthew H. Skorina, Eugene Skobov
  • Patent number: 9619249
    Abstract: A wall module user interface having a memory with a table driven structure. The structure may incorporate an objects table subject to a dynamic object table capable of rendering display objects such as labels or button icons based on arbitrary comparison conditions against the value of a variable at run time. Also, the structure may incorporate a screen actions table subject to a dynamic actions table to similarly determine an action of the user interface based on arbitrary comparison conditions against the value of a variable. An action may be, for example, going to a next screen, where the next screen is determined by the value of the variable at run time.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 11, 2017
    Assignee: Honeywell International Inc.
    Inventors: Paul Grinberg, Miroslav Mikulica, Ralph C. Brindle, Paul C. Wacker
  • Patent number: 9239718
    Abstract: A system for upgrading firmware in multiple units or devices of a building control or automation system. A computer may have a tool that can reflash the firmware with an upgrade. The tool may reflash the firmware of multiple devices automatically without intervention of an operator. Devices having firmware that need an upgrade may be identified and classified as eligible for a firmware upgrade. Devices having firmware similar to firmware in other devices may be grouped with the latter devices for upgrading together, sequentially or in parallel, to simplify and expedite firmware upgrading of the devices. Firmware of devices in the field may be upgraded via a communication network or the like by the computer with the tool. The firmware upgrade, communications and/or associated activity associated with the upgrade may be proprietary and/or secured from public availability.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: January 19, 2016
    Assignee: Honeywell International Inc.
    Inventors: Paul Grinberg, Gary Kasper, Jeffrey Randall
  • Patent number: 9141407
    Abstract: A system and approach for defining labels for values, such as ordinal numbers, of enumerated parameters in a wall module. Label and number pairs may be downloaded to a wall module as part of definitions of the parameters. The wall module may be a source of a list of labels to a user and then set each parameter to a value associated with a label selected by the user.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: September 22, 2015
    Assignee: Honeywell International Inc.
    Inventors: Gary Kasper, Paul Wacker, Paul Grinberg, William Bray, Aaron D'Souza
  • Publication number: 20150254799
    Abstract: A flexible fixed-content dynamically changeable wall module user interface having a memory with a table driven structure. The structure may incorporate an objects table subject to a dynamic object table capable of rendering display objects such as labels or button icons based on arbitrary comparison conditions against the value of a variable at run time. Also, the structure may incorporate a screen actions table subject to a dynamic actions table to similarly determine an action of the user interface based on arbitrary comparison conditions against the value of a variable. An action may be, for example, going to a next screen, where the next screen is determined by the value of the variable at run time.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 10, 2015
    Applicant: Honeywell International Inc.
    Inventors: Paul Grinberg, Miroslav Mikulica, Ralph C. Brindle, Paul C. Wacker
  • Publication number: 20140173581
    Abstract: A system for upgrading firmware in multiple units or devices of a building control or automation system. A computer may have a tool that can reflash the firmware with an upgrade. The tool may reflash the firmware of multiple devices automatically without intervention of an operator. Devices having firmware that need an upgrade may be identified and classified as eligible for a firmware upgrade. Devices having firmware similar to firmware in other devices may be grouped with the latter devices for upgrading together, sequentially or in parallel, to simplify and expedite firmware upgrading of the devices. Firmware of devices in the field may be upgraded via a communication network or the like by the computer with the tool. The firmware upgrade, communications and/or associated activity associated with the upgrade may be proprietary and/or secured from public availability.
    Type: Application
    Filed: December 18, 2012
    Publication date: June 19, 2014
    Applicant: HONEYWELL INTERNATIONAL INC.
    Inventors: Paul Grinberg, Gary Kasper, Jeffrey Randall
  • Publication number: 20140137022
    Abstract: A system and approach for defining labels for values, such as ordinal numbers, of enumerated parameters in a wall module. Label and number pairs may be downloaded to a wall module as part of definitions of the parameters. The wall module may be a source of a list of labels to a user and then set each parameter to a value associated with a label selected by the user.
    Type: Application
    Filed: November 14, 2012
    Publication date: May 15, 2014
    Applicant: Honeywell International Inc.
    Inventors: Gary Kasper, Paul Wacker, Paul Grinberg, William Bray, Aaron D'Souza
  • Patent number: 8443110
    Abstract: A system for discovering devices on a common bus without direct communication. Each device on the bus has a unique identification. One of the devices or a computer may be a master or a host. The host may broadcast a request asking every device with an identification value in a particular range to respond. If no device or one device exists on the bus in this particular range, then there is no or one response, respectively. If multiple devices exist within the range, then multiple responses may be received by the host. In a case of multiple responses, the host may re-transmit its request to one or more half ranges. If multiple responses are again received, then the host may again re-transmit its request where the half range or ranges are again split in half. This approach of half-range reduction may be repeated until no more collisions occur.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: May 14, 2013
    Assignee: Honeywell International Inc.
    Inventor: Paul Grinberg
  • Publication number: 20120221746
    Abstract: A system for discovering devices on a common bus without direct communication. Each device on the bus has a unique identification. One of the devices or a computer may be a master or a host. The host may broadcast a request asking every device with an identification value in a particular range to respond. If no device or one device exists on the bus in this particular range, then there is no or one response, respectively. If multiple devices exist within the range, then multiple responses may be received by the host. In a case of multiple responses, the host may re-transmit its request to one or more half ranges. If multiple responses are again received, then the host may again re-transmit its request where the half range or ranges are again split in half. This approach of half-range reduction may be repeated until no more collisions occur.
    Type: Application
    Filed: February 28, 2011
    Publication date: August 30, 2012
    Applicant: HONEYWELL INTERNATIONAL INC.
    Inventor: Paul Grinberg
  • Patent number: 7783938
    Abstract: Provided is a method and system for diagnosing a test system to determine whether a condition of the test system contributed to an undesirable measurement result. The method includes interrogating a device under test comprising at least one of transmitting an electric signal to energize a device under test by the test system and conducting a passive measurement that does not require the device under test to be energized to be performed to determine if the device under test satisfies a design parameter. The method further includes processing an output signal including at least one of a responsive electric signal transmitted from the device under test in response to being energized and a passive signal corresponding to the passive measurement, and comparing a value of a property of the output signal to a reference value. Responsive to the comparing, the method determines whether the value of the output signal is within an acceptable tolerance of the reference value.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: August 24, 2010
    Assignee: Keithly Instruments, Inc.
    Inventors: William F. Merkel, Paul Grinberg