Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-? ligand trap, and methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-? signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-? ligand trap to reduce right ventricular systolic pressure in a subject.

Abstract: An extra-cardiovascular implantable cardioverter defibrillator (ICD) having a high voltage therapy module is configured to control a high voltage charging circuit to charge a capacitor to a pacing voltage amplitude to deliver charge balanced pacing pulses. The capacitor is chargeable to a shock voltage amplitude that is greater than the pacing voltage amplitude. The ICD is configured to enable switching circuitry of the high voltage therapy module to discharge the capacitor to deliver a first pulse having a first polarity and a leading voltage amplitude corresponding to the pacing voltage amplitude for pacing the patient's heart via a pacing electrode vector selected from extra-cardiovascular electrodes. The high voltage therapy module delivers a second pulse after the first pulse. The second pulse has a second polarity opposite the first polarity and balances the electrical charge delivered during the first pulse.

Abstract: An implantable cardioverter defibrillator (ICD) receives a cardiac electrical signal by a sensing circuit while operating in a sensing without pacing mode and detects asystole based on the cardiac electrical signal. The ICD determines, in response to detecting the asystole, if asystole backup pacing is enabled, and automatically switches to a temporary pacing mode in response to the asystole backup pacing being enabled. Other examples of detecting asystole and providing a response to detecting asystole by the ICD are described herein.

Abstract: Aspects of the disclosure are directed toward systems and methods for combining aspects of a plurality of indexed images taken at different focus distances in order to generate a final image having objects at a variety of depths remain in focus. High frequency frames associated with each of the plurality of images can be generated, each high frequency frame being representative of the high frequency content of the associated image. The high frequency content in a plurality of regions in each of the plurality of high frequency frames can be analyzed to determine which regions include valid high frequency content. A final image can be generated comprising, for each of the plurality of regions, image data from the image having like index as the high frequency frame having the greatest valid high frequency content in that region.

Abstract: Aspects of the disclosure are directed toward systems and methods for combining aspects of a plurality of indexed images taken at different focus distances in order to generate a final image having objects at a variety of depths remain in focus. High frequency frames associated with each of the plurality of images can be generated, each high frequency frame being representative of the high frequency content of the associated image. The high frequency content in a plurality of regions in each of the plurality of high frequency frames can be analyzed to determine which regions include valid high frequency content. A final image can be generated comprising, for each of the plurality of regions, image data from the image having like index as the high frequency frame having the greatest valid high frequency content in that region.

Abstract: A wall module user interface having a memory with a table driven structure. The structure may incorporate an objects table subject to a dynamic object table capable of rendering display objects such as labels or button icons based on arbitrary comparison conditions against the value of a variable at run time. Also, the structure may incorporate a screen actions table subject to a dynamic actions table to similarly determine an action of the user interface based on arbitrary comparison conditions against the value of a variable. An action may be, for example, going to a next screen, where the next screen is determined by the value of the variable at run time.

Abstract: A system for upgrading firmware in multiple units or devices of a building control or automation system. A computer may have a tool that can reflash the firmware with an upgrade. The tool may reflash the firmware of multiple devices automatically without intervention of an operator. Devices having firmware that need an upgrade may be identified and classified as eligible for a firmware upgrade. Devices having firmware similar to firmware in other devices may be grouped with the latter devices for upgrading together, sequentially or in parallel, to simplify and expedite firmware upgrading of the devices. Firmware of devices in the field may be upgraded via a communication network or the like by the computer with the tool. The firmware upgrade, communications and/or associated activity associated with the upgrade may be proprietary and/or secured from public availability.

Abstract: A system and approach for defining labels for values, such as ordinal numbers, of enumerated parameters in a wall module. Label and number pairs may be downloaded to a wall module as part of definitions of the parameters. The wall module may be a source of a list of labels to a user and then set each parameter to a value associated with a label selected by the user.

Abstract: A flexible fixed-content dynamically changeable wall module user interface having a memory with a table driven structure. The structure may incorporate an objects table subject to a dynamic object table capable of rendering display objects such as labels or button icons based on arbitrary comparison conditions against the value of a variable at run time. Also, the structure may incorporate a screen actions table subject to a dynamic actions table to similarly determine an action of the user interface based on arbitrary comparison conditions against the value of a variable. An action may be, for example, going to a next screen, where the next screen is determined by the value of the variable at run time.

Abstract: A system for upgrading firmware in multiple units or devices of a building control or automation system. A computer may have a tool that can reflash the firmware with an upgrade. The tool may reflash the firmware of multiple devices automatically without intervention of an operator. Devices having firmware that need an upgrade may be identified and classified as eligible for a firmware upgrade. Devices having firmware similar to firmware in other devices may be grouped with the latter devices for upgrading together, sequentially or in parallel, to simplify and expedite firmware upgrading of the devices. Firmware of devices in the field may be upgraded via a communication network or the like by the computer with the tool. The firmware upgrade, communications and/or associated activity associated with the upgrade may be proprietary and/or secured from public availability.

Abstract: A system and approach for defining labels for values, such as ordinal numbers, of enumerated parameters in a wall module. Label and number pairs may be downloaded to a wall module as part of definitions of the parameters. The wall module may be a source of a list of labels to a user and then set each parameter to a value associated with a label selected by the user.

Abstract: A system for discovering devices on a common bus without direct communication. Each device on the bus has a unique identification. One of the devices or a computer may be a master or a host. The host may broadcast a request asking every device with an identification value in a particular range to respond. If no device or one device exists on the bus in this particular range, then there is no or one response, respectively. If multiple devices exist within the range, then multiple responses may be received by the host. In a case of multiple responses, the host may re-transmit its request to one or more half ranges. If multiple responses are again received, then the host may again re-transmit its request where the half range or ranges are again split in half. This approach of half-range reduction may be repeated until no more collisions occur.

Abstract: A system for discovering devices on a common bus without direct communication. Each device on the bus has a unique identification. One of the devices or a computer may be a master or a host. The host may broadcast a request asking every device with an identification value in a particular range to respond. If no device or one device exists on the bus in this particular range, then there is no or one response, respectively. If multiple devices exist within the range, then multiple responses may be received by the host. In a case of multiple responses, the host may re-transmit its request to one or more half ranges. If multiple responses are again received, then the host may again re-transmit its request where the half range or ranges are again split in half. This approach of half-range reduction may be repeated until no more collisions occur.

Abstract: Provided is a method and system for diagnosing a test system to determine whether a condition of the test system contributed to an undesirable measurement result. The method includes interrogating a device under test comprising at least one of transmitting an electric signal to energize a device under test by the test system and conducting a passive measurement that does not require the device under test to be energized to be performed to determine if the device under test satisfies a design parameter. The method further includes processing an output signal including at least one of a responsive electric signal transmitted from the device under test in response to being energized and a passive signal corresponding to the passive measurement, and comparing a value of a property of the output signal to a reference value. Responsive to the comparing, the method determines whether the value of the output signal is within an acceptable tolerance of the reference value.