Patents by Inventor Paul Gris

Paul Gris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of SOX9 function in the treatment of proteoglycan-associated pathophysiological conditions
    Patent number: 8791084
    Abstract: A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: July 29, 2014
    Assignee: Robarts Research Institute
    Inventors: Arthur Brown, Paul Gris
  • INHIBITION OF SOX9 FUNCTION IN THE TREATMENT OF PROTEOGLYCAN-ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS
    Publication number: 20100028364
    Abstract: A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.
    Type: Application
    Filed: October 25, 2007
    Publication date: February 4, 2010
    Applicant: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Arthur Brown, Paul Gris