Patents by Inventor PAUL H. KUSSIE

PAUL H. KUSSIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof
    Publication number: 20110142822
    Abstract: The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.
    Type: Application
    Filed: June 14, 2005
    Publication date: June 16, 2011
    Inventors: Paul H. Kussie, Kathryn M. Ferguson
  • CO-CRYSTAL OF ANTIBODY 11F8FAB FRAGMENT AND EGFR EXTRACELLULAR DOMAIN AND USES THEREOF
    Publication number: 20100086540
    Abstract: The present invention relates to co-crystals of antibody 11F8 Fab fragments and the complete extracellular domain of EGFR or isolated domain III of EGFR, and structural coordinates obtained from such crystals. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may, for example, inhibit binding of ligands to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.
    Type: Application
    Filed: June 30, 2009
    Publication date: April 8, 2010
    Inventors: PAUL H. KUSSIE, KATHRYN M. FERGUSON