Patents by Inventor Paul H. O'Brien

Paul H. O'Brien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-marker RT-PCR panel for detecting metastatic breast cancer
    Patent number: 6037129
    Abstract: A method of detecting the metastasis of primary breast cancer to a lymph node is provided, comprising detecting, in lymph node tissue, the presence of a nucleic acid of c-myc, PIP or keratin-19. The presence of any one of these nucleic acids in lymph node tissue is associated with metastatic breast cancer. The presence of one or more of these markers in lymph node tissue or other tissue indicates that cells from the primary tumor have migrated from the breast tissue to the lymph node or other tissue. Also provided is a method of predicting the histopathologic stage of a cancer in a patient without having to perform a histopathologic analysis, comprising detecting, in lymph node tissue from the patient, the presence of a nucleic acid of c-myc, the presence of a nucleic acid of c-myc being correlated with stage I cancer as determined by histopathology.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: March 14, 2000
    Assignee: Medical University of South Carolina
    Inventors: David J. Cole, Paul L. Baron, Paul H. O'Brien