Abstract: A floor cleaning system having a flat headed mop is provided. The system includes a bucket having a wringing assembly. A blade including a first angled portion is provided for that is adjacent a plurality of first openings for compressing the flat headed mop as it is inserted in the wringing assembly to remove dirt and debris accumulated during use. A second angled portion is provided for adjacent a plurality of second openings for compressing the flat headed mop as it is withdrawn from the wringing assembly.

Abstract: Provided herein, in certain embodiments, are various methods, reagents, and devices for detection of multiple target nucleic acids in a sample, or multiple segments of a target nucleic acid in a sample, using a programmable nuclease. In certain embodiments, the present disclosure provides compositions of pools of guide nucleic acids, programmable nucleases, and detector nucleic acids and methods of using said compositions for detection of different segments of one target nucleic acid or different target nucleic acids in a sample.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: An intelligent impedance injection module is for use with transmission lines in a power grid. The intelligent impedance injection module has a plurality of transformer-less impedance injector units and a controller. The controller changes injector gain of the impedance injector units to compensate for current swings in a transmission line.

Abstract: An intelligent impedance injection module is for use with transmission lines in a power grid. The intelligent impedance injection module has a plurality of transformer-less impedance injector units and a controller. The controller changes injector gain of the impedance injector units to compensate for current swings in a transmission line.

Abstract: A checkout terminal for customers in a retail store. The terminal provides a path for products from a loading conveyor section, via a scanning section and a common transfer conveyor section, to reach a respective one of a plurality of plurality of packing stations to be bagged or packed by or for the customer. Conveniently, three of these packing stations are arranged substantially parallel to each other. Each packing station may be associated with a corresponding payment interface. Customer throughput is increased by providing multiple packing areas associated with one loading and scanning area, and customer convenience is improved by the faster and more efficient configuration of the checkout terminal.

Abstract: An extensible software application utilizes rules to initiate a behavior that performs operations that customize the extensible software application in a preferred manner. The behavior is applied when pre-defined events occur during execution of the extensible software application. The rules are provided by a third party developer in metadata that is separate from the extension's program code. The rules are based on expressions that define the events that need to take place during the execution of the extensible software application before the behavior is applied.

Abstract: A checkout terminal for customers in a retail store. The terminal provides a path for products from a loading conveyor section, via a scanning section and a common transfer conveyor section, to reach a respective one of a plurality of plurality of packing stations to be bagged or packed by or for the customer. Conveniently, three of these packing stations are arranged substantially parallel to each other. Each packing station may be associated with a corresponding payment interface. Customer throughput is increased by providing multiple packing areas associated with one loading and scanning area, and customer convenience is improved by the faster and more efficient configuration of the checkout terminal.

Abstract: An extensible software application utilizes rules to initiate a behavior that performs operations that customize the extensible software application in a preferred manner. The behavior is applied when pre-defined events occur during execution of the extensible software application. The rules are provided by a third party developer in metadata that is separate from the extension's program code. The rules are based on expressions that define the events that need to take place during the execution of the extensible software application before the behavior is applied.

Abstract: The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

Abstract: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.

Abstract: The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

Abstract: The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.

Abstract: The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

Abstract: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.

Abstract: The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.