Patents by Inventor Paul Hastwell

Paul Hastwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genotoxic testing
    Patent number: 8969008
    Abstract: The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding a reporter protein operatively linked to a human GADD45? gene promoter and a human GADD45? gene regulatory element arranged to activate expression of the DNA sequence in response to DNA damage) to an agent; and monitoring the expression of the reporter protein from the cell. The invention also concerns expression cassettes, vectors and cells which may be used according to such a method and also modified media that may be employed in fluorescence assays and in preferred embodiments of the method of the invention.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: March 3, 2015
    Assignee: Gentronix Limited
    Inventors: Paul Hastwell, Richard Walmsley
  • GENOTOXIC TESTING
    Publication number: 20130316362
    Abstract: The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding a reporter protein operatively linked to a human GADD45? gene promoter and a human GADD45? gene regulatory element arranged to activate expression of the DNA sequence in response to DNA damage) to an agent; and monitoring the expression of the reporter protein from the cell. The invention also concerns expression cassettes, vectors and cells which may be used according to such a method and also modified media that may be employed in fluorscence assays and in preferred embodiments of the method of the invention.
    Type: Application
    Filed: April 10, 2013
    Publication date: November 28, 2013
    Applicant: GENTRONIX LIMITED
    Inventors: Paul Hastwell, Richard Walmsley
  • Genotoxic Testing
    Publication number: 20070224609
    Abstract: The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding a reporter protein operatively linked to a human GADD45? gene promoter and a human GADD45? gene regulatory element arranged to activate expression of the DNA sequence in response to DNA damage) to an agent; and monitoring the expression of the reporter protein from the cell. The invention also concerns expression cassettes, vectors and cells which may be used according to such a method and also modified media that may be employed in fluorescence assays and in preferred embodiments of the method of the invention.
    Type: Application
    Filed: May 18, 2005
    Publication date: September 27, 2007
    Inventors: Paul Hastwell, Richard Walmsley