Patents by Inventor Paul Hendrik Maria Savelkoul

Paul Hendrik Maria Savelkoul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11359249
    Abstract: The present invention relates to a method of typing a microbiome for having a desirable or undesirable signature, comprising analyzing the composition of the population of microorganisms in the microbiome based on taxonomic variation in the DNA sequence of the microbial 16S-23S rRNA internal transcribed spacer (ITS) regions in the genomic DNA of the microorganisms, wherein the sequences of conserved DNA regions comprised in the 16S and 23S rRNA sequences flanking said ITS region in the genome of the microorganisms comprise primer binding sites for amplification of the ITS regions.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: June 14, 2022
    Assignee: IS-DIAGNOSTICS LTD
    Inventors: Andries Edward Budding, Paul Hendrik Maria Savelkoul
  • Publication number: 20170349937
    Abstract: The invention relates to methods for detecting microbial blood infections including sepsis in a subject, preferably a neonate or a non-neonate such as an adult, the method comprising real-time PCR reactions for detection of specific microorganisms. Said methods preferably include treatment of a subject following detection of a specific microorganism or group of microorganisms. The invention further relates to a kit of parts adapted for performing a method of the invention, a set of at least one forward or re verse primer or probe and a method for monitoring sepsis or for determining the efficacy of an anti-sepsis treatment.
    Type: Application
    Filed: July 25, 2015
    Publication date: December 7, 2017
    Inventor: Paul Hendrik Maria Savelkoul
  • Publication number: 20170159108
    Abstract: The present invention relates to a method of typing a microbiome for having a desirable or undesirable signature, comprising analyzing the composition of the population of microorganisms in said microbiome based on taxonomic variation in the DNA sequence of the microbial 16S-23S rRNA internal transcribed spacer (ITS) regions in the genomic DNA of said microorganisms, wherein the sequences of conserved DNA regions comprised in the 16S and 23S rRNA sequences flanking said ITS region in the genome of said microorganisms comprise primer binding sites for amplification of said ITS regions.
    Type: Application
    Filed: May 6, 2015
    Publication date: June 8, 2017
    Inventors: Andries Edward BUDDING, Paul Hendrik Maria SAVELKOUL
  • Patent number: 9506109
    Abstract: The current invention relates to a method for analysis of a population of micro-organisms (e.g. bacterial population) of different taxonomic groups in an environment suspected to contain said bacteria, primers, primer sets and pair of primer sets suitable for use is such method, and use of such method in determining the effect of external factors like drugs, nutrients and pesticides on bacterial populations of different taxonomic groups.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: November 29, 2016
    Assignee: Microbiome Limited
    Inventors: Paul Hendrik Maria Savelkoul, Andries Edward Budding
  • Patent number: 8536321
    Abstract: Method for the detection of Chlamydia trachomatis, which method comprises the performance of a DNA amplification involving the use of a primer pair by using DNA that is derived from a sample as a template and the detection of an amplification product, characterized in that the primer pair used for the DNA amplification is designed on the basis of nucleotide sequences of the regions corresponding to the nucleotide numbers 3654 to 4320 and 4351 to 4448 in the nucleotide sequence of SEQ ID No. 1.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: September 17, 2013
    Assignee: Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patientenzorg
    Inventors: Paul Hendrik Maria Savelkoul, Arnold Catsburg, Antonie Servaas Morre
  • Publication number: 20130045476
    Abstract: The invention relates to methods for combined monitoring of detection of at least two molecular targets.
    Type: Application
    Filed: February 11, 2011
    Publication date: February 21, 2013
    Inventors: Paul Hendrik Maria Savelkoul, Maria Hendrika Anna Hemans
  • Publication number: 20110020796
    Abstract: Method for the detection of Chlamydia trachomatis, which method comprises the performance of a DNA amplification involving the use of a primer pair by using DNA that is derived from a sample as a template and the detection of an amplification product, characterized in that the primer pair used for the DNA amplification is designed on the basis of nucleotide sequences of the regions corresponding to the nucleotide numbers 3654 to 4320 and 4351 to 4448 in the nucleotide sequence of SEQ ID No. 1.
    Type: Application
    Filed: February 6, 2008
    Publication date: January 27, 2011
    Applicant: Vereniging Voor Christelijk Hoger Onderwijs Wetens chappelljk Onderzoek En Patientenzorg
    Inventors: Paul Hendrik Maria Savelkoul, Arnold Catsburg, Antonie Servaas Morre
  • Publication number: 20100129816
    Abstract: The current invention relates to a method for analysis of a population of micro-organisms (e.g. bacterial population) of different taxonomic groups in an environment suspected to contain said bacteria, primers, primer sets and pair of primer sets suitable for use is such method, and use of such method in determining the effect of external factors like drugs, nutrients and pesticides on bacterial populations of different taxonomic groups.
    Type: Application
    Filed: April 17, 2008
    Publication date: May 27, 2010
    Applicant: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelljk Onderzoek En Patientenzorg
    Inventors: Paul Hendrik Maria Savelkoul, Andries Edward Budding