Patents by Inventor Paul Hruz

Paul Hruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLUT4 Selective Inhibitors for Cancer Therapy
    Publication number: 20190321345
    Abstract: This disclosure relates to GLUT 4 inhibitors and uses as chemotherapy agents. In certain embodiments, this disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a GLUT 4 inhibitor disclosed herein to a subject in need thereof. In certain embodiments, the GLUT 4 inhibitor has Formula (I), prodrugs, derivatives, or salts thereof wherein the substituents are reported herein. In certain embodiments, the GLUT 4 inhibitor is N-(3-(4-fluorophenethoxy)benzyl)-2-(4-methoxyphenyl)-N-(pyridin-4-ylmethyl)acetamide or salts thereof.
    Type: Application
    Filed: December 28, 2017
    Publication date: October 24, 2019
    Inventors: Malathy Shanmugam, Gary Schiltz, Rama Mishra, Paul Hruz
  • INHIBITORS OF MALARIAL AND HUMAN GLUCOSE TRANSPORTERS AND METHODS FOR IDENTIFYING THE INHIBITORS
    Publication number: 20170307590
    Abstract: Inhibitors of glucose transporter Plasmodium falciparum hexose transporter (PfHT) are provided herein. Further, a cell-based, high-throughput assay that directly measures the ability of a compound to inhibit glucose transport by PfHT is provided.
    Type: Application
    Filed: April 20, 2017
    Publication date: October 26, 2017
    Inventors: Paul Hruz, Thomas E. Kraft, Brian DeBosch