Patents by Inventor Paul Hujsak

Paul Hujsak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for separating rare cells from fluid samples
    Publication number: 20070202536
    Abstract: The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.
    Type: Application
    Filed: August 2, 2006
    Publication date: August 30, 2007
    Inventors: Douglas Yamanishi, Paul Hujsak, Sara Snyder, George Walker, Junquan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Charina Schmitigal, Samantha O'Neill, Jing Cheng, Jia Xu
  • Methods, compositions, and automated systems for separating rare cells from fluid samples
    Patent number: 7166443
    Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients. The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: January 23, 2007
    Assignee: Aviva Biosciences Corporation
    Inventors: George Walker, Junquan Xu, Douglas Yamanishi, Paul Hujsak, Lei Wu, Mingxian Huang, Guoliang Tao, Sara Snyder, Charina Yap
  • Methods and compositions for detecting non-hematopoietic cells from a blood sample
    Publication number: 20060252054
    Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.
    Type: Application
    Filed: October 31, 2005
    Publication date: November 9, 2006
    Inventors: Ping Lin, Douglas Yamanishi, Paul Hujsak, Sara Snyder, George Walker, Junguan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Charina Schmitigal, Samantha O'Neill, Jing Cheng, Elizabeth Voung, Jia Xu
  • Methods, compositions, and automated systems for separating rare cells from fluid samples
    Patent number: 6949355
    Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients. A first aspect of the present invention is a microfabricated filter for filtering a fluid sample. A microfabricated filter of the present invention comprises at least one tapered pore, and preferably comprises at least two tapered pores whose variation in size is 20% or less. The present invention also includes a method of enriching rare cells of a fluid sample using a microfabricated filter of the present invention.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: September 27, 2005
    Assignee: AVIVA Biosciences
    Inventors: Douglas Yamanishi, Paul Hujsak, Zhaohuai Yang, J{dot over (u)}nquan Xu, Xiaobo Wang, Lei Wu, Mingxian Huang, Guoliang Tao, Jing Cheng
  • Methods, compositions, and automated systems for separating rare cells from fluid samples
    Publication number: 20040142463
    Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients. The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample.
    Type: Application
    Filed: November 4, 2003
    Publication date: July 22, 2004
    Inventors: George Walker, Junquan Xu, Douglas Yamanishi, Paul Hujsak, Lei Wu, Mingxian Huang, Guoliang Tao, Sara Snyder, Charina Yap
  • Methods, compositions, and automated systems for separating rare cells from fluid samples
    Publication number: 20030134416
    Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients.
    Type: Application
    Filed: October 10, 2002
    Publication date: July 17, 2003
    Inventors: Douglas Yamanishi, Paul Hujsak, Zhaohuai Yang, Junquan Xu, Xiaobo Wang, Lei Wu, Mingxian Huang, Guoliang Tao, Jing Cheng