Abstract: The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, characterised in that the dicistronic message comprises a sequence selected from AEOS1 (SEQ ID NO:1), AEOS2 (SEQ ID NO:2), AEOS3 (SEQ ID NO:3), AEOS4 (SEQ ID NO: 4), AEOS5 (SEQ ID NO:5), AEOS6 (SEQ ID NO:6), AEOS7 (SEQ ID NO:7), AEOS8 (SEQ ID NO:8), AEOS9 (SEQ ID NO:9), AEOS1O (SEQ ID NO:10) and AEOS1 1 (SEQ ID NO:11).

Abstract: The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.

Abstract: Expression vectors encoding bacteriophage signal peptides are described. The vectors may be used for the heterologous expression and secretion of polypeptides such as antibodies in bacterial host cells.

Abstract: Expression vectors encoding bacteriophage signal peptides are described. The vectors may be used for the heterologous expression and secretion of polypeptides such as antibodies in bacterial host cells.

Abstract: Peptides comprising the amino acid sequence set forth in SEQ ID NO:1 are described wherein the amino acid at position 7 of SEQ ID NO:1 and the amino acid at position 8 of SEQ ID NO:1, which may be the same or different, is each a neutral aliphatic L-ammo acid residue, and protected and reactive derivatives thereof. The peptides may be used as hinge regions in proteins, wherein they are capable of being covalently coupled to achieve dimeric structures, for example, as found in antibodies.

Abstract: An uninterruptible power supply system comprising a source of a utility power signal, a source of hydrogen, a fuel cell stack, first and second input circuits, an output circuit, and a control circuit. The fuel cell stack converts the hydrogen into a fuel cell output signal. The first input circuit is operatively connected to the utility power signal and outputs a first AC input signal based on the utility power signal. The second input circuit operatively is connected to the fuel cell output signal and generates a second AC input signal based on the fuel cell output signal. The output circuit is operatively connected to the first and second input circuits and outputs at least one output signal based on one of the first and second AC input signals. The control circuit operatively is connected to the fuel cell stack, the first input circuit, the second input circuit. The output circuit controls whether the output signal is generated based on the utility power signal or hydrogen.

Abstract: An uninterruptible power supply system comprising a source of a utility power signal, a source of hydrogen, a fuel cell stack, first and second input circuits, an output circuit, and a control circuit. The fuel cell stack converts the hydrogen into a fuel cell output signal. The first input circuit is operatively connected to the utility power signal and outputs a first AC input signal based on the utility power signal. The second input circuit operatively is connected to the fuel cell output signal and generates a second AC input signal based on the fuel cell output signal. The output circuit is operatively connected to the first and second input circuits and outputs at least one output signal based on one of the first and second AC input signals. The control circuit operatively is connected to the fuel cell stack, the first input circuit, the second input circuit. The output circuit controls whether the output signal is generated based on the utility power signal or hydrogen.