Abstract: The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.

Abstract: The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.

Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C?, D, E, F, G, H?, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C?, D, E, F, G, H?, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C?, D, E, F, G, H?, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

Abstract: The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.

Abstract: Mechanisms are disclosed that allow for the use of a false background, or background tone, in voice input in a telephonic call. A voice input may have both voice from a user talking and a background noise input which may be every other noise received at the user's phone. A trigger to use a background tone is received, the background tone is selected and the associated background tone file is retrieved. Then, a combiner combines the voice input with the background tone file. A filter may be used to filter the actual background noise from the voice input. Additionally, background tones may be used in various telephonic networks, including traditional land-line and wireless cellular networks.

Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.

Abstract: Mechanisms are disclosed that allow for the use of a false background, or background tone, in voice input in a telephonic call. A voice input may have both voice from a user talking and a background noise input which may be every other noise received at the user's phone. A trigger to use a background tone is received, the background tone is selected and the associated background tone file is retrieved. Then, a combiner combines the voice input with the background tone file. A filter may be used to filter the actual background noise from the voice input. Additionally, background tones may be used in various telephonic networks, including traditional land-line and wireless cellular networks.

Abstract: Mechanisms are disclosed that allow for the use of a false background, or background tone, in voice input in a telephonic call. A voice input may have both voice from a user talking and a background noise input which may be every other noise received at the user's phone. A trigger to use a background tone is received, the background tone is selected and the associated background tone file is retrieved. Then, a combiner combines the voice input with the background tone file. A filter may be used to filter the actual background noise from the voice input. Additionally, background tones may be used in various telephonic networks, including traditional land-line and wireless cellular networks.

Abstract: Mechanisms are disclosed that allow for the use of a false background, or background tone, in voice input in a telephonic call. A voice input may have both voice from a user talking and a background noise input which may be every other noise received at the user's phone. A trigger to use a background tone is received, the background tone is selected and the associated background tone file is retrieved. Then, a combiner combines the voice input with the background tone file. A filter may be used to filter the actual background noise from the voice input. Additionally, background tones may be used in various telephonic networks, including traditional land-line and wireless cellular networks.

Abstract: Alpha substituted carboxylic acids of formula (I): wherein R1 and R2 are as defined in the specification and R3 is wherein Y, Ar1, Ar2, Ar3, R4, R5, R6, R7, R8, R9, R9a, R10, R11, R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR ?/? related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.