Patents by Inventor Paul Insel

Paul Insel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10107816
    Abstract: The disclosure provides diagnostic and therapeutic agents for chronic lymphocytic leukemia (CLL). Further provided are biomarkers and a biomarker panel comprising G-protein coupled receptors (GPCRs) specifically expressed by CLL cells. Methods for diagnosing a disease stage of a CLL patient, progression, or prediction of clinical course and drug selection for the CLL patient, as well as methods for treating CLL, by targeting these GPCR biomarkers are also provided.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: October 23, 2018
    Assignee: The Regents of the University of California
    Inventors: Paul Insel, Fiona Murray, Lingzhi Zhang, Trishna Katakia, Andrea Wilderman, Charles Gray
  • Publication number: 20160349261
    Abstract: The disclosure provides diagnostic and therapeutic agents for chronic lymphocytic leukemia (CLL). Further provided are biomarkers and a biomarker panel comprising G-protein coupled receptors (GPCRs) specifically expressed by CLL cells. Methods for diagnosing a disease stage of a CLL patient, progression, or prediction of clinical course and drug selection for the CLL patient, as well as methods for treating CLL, by targeting these GPCR biomarkers are also provided.
    Type: Application
    Filed: April 8, 2014
    Publication date: December 1, 2016
    Inventors: Paul Insel, Fiona Murray, Lingzhi Zhang, Trishna Katakia, Andrea Wilderman, Charles Gray
  • Publication number: 20160169918
    Abstract: Diagnostic and therapeutic agents for pulmonary arterial hypertension (PAH) are provided. Circulating microparticles (MPs) and/or the expression level of GPR75 are significantly increased in PAH-PASMC, but not normal PASMC, thus, providing a non-invasive diagnostic method for PAH. Furthermore targeting MPs and/or GPR75 with specific antibodies, inverse agonists or antagonists is a strategy to treat PAH.
    Type: Application
    Filed: July 31, 2014
    Publication date: June 16, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Fiona Murray, Paul Insel, Nakon Aroonsakool, Daniel McDonald, Ohmin Kwon
  • Publication number: 20050250721
    Abstract: The present invention relates to methods and compositions for enhancing cardiac function in mammalian hearts by inserting transgenes that increase beta-adrenergic responsiveness within the myocardium. The present invention can thus be used in the treatment of heart disease, especially congestive heart failure.
    Type: Application
    Filed: September 14, 2004
    Publication date: November 10, 2005
    Inventors: H. Hammond, Paul Insel, Peipei Ping, Steven Post, Meihua Gao