Patents by Inventor Paul J. Hung

Paul J. Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture and invasion assay method and system
    Patent number: 11034925
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: June 15, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Paul J. Hung, Philip J. Lee
  • Methods and apparatus for cell culture array
    Patent number: 10843189
    Abstract: Methods and systems are described for improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: November 24, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • Cell Culture And Invasion Assay Method And System
    Publication number: 20200208089
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Application
    Filed: December 13, 2019
    Publication date: July 2, 2020
    Inventors: Paul J. Hung, Philip J. Lee
  • Cell culture and invasion assay method and system
    Patent number: 10526572
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: January 7, 2020
    Assignee: EMD Millipore Corporaticn
    Inventors: Paul J. Hung, Philip J. Lee
  • METHODS AND APPARATUS FOR CELL CULTURE ARRAY
    Publication number: 20190106664
    Abstract: Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Application
    Filed: March 19, 2018
    Publication date: April 11, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • Cell culture array system for automated assays and methods of operation and manufacture
    Patent number: 10138453
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: November 27, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Paul J. Hung, Philip J. Lee
  • Methods and apparatus for cell culture array
    Patent number: 9969963
    Abstract: Methods and systems are described for improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: May 15, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • Cell Culture And Invasion Assay Method And System
    Publication number: 20170267961
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Paul J. Hung, Philip J. Lee
  • Cell culture and invasion assay method and system
    Patent number: 9637715
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Grant
    Filed: April 1, 2012
    Date of Patent: May 2, 2017
    Assignee: EMD Millipore Corporation
    Inventors: Paul J. Hung, Philip J. Lee
  • Microfluidic Cell Culture Systems
    Publication number: 20160333298
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation.
    Type: Application
    Filed: June 7, 2016
    Publication date: November 17, 2016
    Inventors: Paul J. Hung, Philip J. Lee
  • Cell Culture Array System For Automated Assays And Methods Of Operation And Manufacture
    Publication number: 20160289623
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.
    Type: Application
    Filed: May 24, 2016
    Publication date: October 6, 2016
    Inventors: Paul J. Hung, Phillip J. Lee
  • Microfluidic cell culture systems
    Patent number: 9388374
    Abstract: In one embodiment, a microfluidic structure comprises a culture chamber having an object flow inlet disposed between a pair of object flow outlets. A flow-around channel provides fluidic mass transport to the culture chamber through a perfusion barrier disposed opposite from the object flow inlet and object flow outlets. The perfusion barrier surrounds the culture chamber, defines an opposite wall of the culture chamber, and prevents cell passage into the flow around-channel. The perfusion barrier creates a low fluidic resistance path within the culture chamber, such that a flow of cells entering the culture chamber from the object flow inlet encounters a flow of media passing through the perfusion barrier. This causes the cells to take an approximately 180 degree turn and exit the culture chamber via the object flow outlets. The low fluidic resistance path allows the cells to settle onto the chamber floor without needing any physical barrier.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: July 12, 2016
    Assignee: EMD Millipore Corporation
    Inventors: Paul J. Hung, Philip J. Lee
  • Cell culture array system for automated assays and methods of operation and manufacture thereof
    Patent number: 9376658
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: June 28, 2016
    Assignee: EMD Millipore Corporation
    Inventors: Paul J. Hung, Philip J. Lee
  • METHODS AND APPARATUS FOR CELL CULTURE ARRAY
    Publication number: 20160075984
    Abstract: Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Application
    Filed: September 16, 2015
    Publication date: March 17, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • Methods and apparatus for cell culture array
    Patent number: 9260688
    Abstract: Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: February 16, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • CELL CULTURE AND INVASION ASSAY METHOD AND SYSTEM
    Publication number: 20130059322
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Application
    Filed: April 1, 2012
    Publication date: March 7, 2013
    Applicant: CellASIC, INC.
    Inventors: Paul J. Hung, Philip J. Lee
  • MICROFLUIDIC CELL CULTURE SYSTEMS
    Publication number: 20120003732
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation.
    Type: Application
    Filed: January 21, 2011
    Publication date: January 5, 2012
    Applicant: CellASIC, INC.
    Inventors: Paul J. Hung, Philip J. Lee
  • CELL CULTURE ARRAY SYSTEM FOR AUTOMATED ASSAYS AND METHODS OF OPERATION AND MANUFACTURE THEREOF
    Publication number: 20090203126
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.
    Type: Application
    Filed: January 5, 2009
    Publication date: August 13, 2009
    Inventors: Paul J. Hung, Philip J. Lee
  • METHODS AND APPARATUS FOR CELL CULTURE ARRAY
    Publication number: 20090023608
    Abstract: Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Application
    Filed: July 6, 2006
    Publication date: January 22, 2009
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee