Patents by Inventor Paul J. J. Hooykaas

Paul J. J. Hooykaas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Agrobacterium bacteria capable of site-specific recombination
    Patent number: 5635381
    Abstract: The invention provides Agrobacterium strains capable of producing a cite-specific recombinase capable of effecting site-specific recombination of a first and a second recombination site in Agrobacterium strains, when present therein, comprising a structural DNA sequence encoding said recombinase and a DNA sequence capable of controlling expression in Agrobacterium strains. The invention also provides methods for using the strains to transform plant cells.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: June 3, 1997
    Assignee: Mogen International NV
    Inventors: Paul J. J. Hooykaas, Teresa Mozo
  • Process for the site-directed integration of DNA into the genome of plants
    Patent number: 5501967
    Abstract: The present invention provides a method for site-directed integration of DNA-sequences into the genome of plants via homologous recombination, by transforming said plants using the DNA-transfer system of Agrobacterium, in which the transforming DNA comprises in its most simple form a region homologous to the target locus, as well as a region which is different from the target locus either next to one or between two T-DNA borders.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: March 26, 1996
    Assignee: Mogen International, n.v./Rijksuniversiteit te Leiden
    Inventors: Remko Offringa, Marcellus J. A. De Groot, Paul J. J. Hooykaas, Petrus J. M. Van Den Elzen
  • Process for introducing foreign DNA into the genome of plants
    Patent number: 5149645
    Abstract: Process for introducing foreign DNA into the genome of plants by infecting plants or explantates thereof or plant protoplasts or by incubating plant protoplasts with Agrobacterium, in which Agrobacteria are used, which contain one or more T-regions and a Vir-region from the Ti-plasmid of Agrobacterium in their genetic material and/or one or more T-regions comprising an artificial T-region which consists of each DNA desired, flanked by border sequences as present in the wild type T-region of Agrobacterium or sequences being functionally analogous thereto.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: September 22, 1992
    Assignees: Rijksuniversiteit Leiden, Robbert Adriaan Scilperoort
    Inventors: Andre Hoekema, Paul J. J. Hooykaas, Robert A. Schilperoort
  • Process for the incorporation of foreign dna into the genome of dicotyledonous plants
    Patent number: 4940838
    Abstract: The invention relates to a process for the incorporation of foreign DNA into chromosomes of dicotyledonous plants by infecting the plants or incubating plant protoplasts with Agrobacterium bacteria, which contain one or more plasmids, wherein bacteria are used which contain at least one plasmid having the vir-region of a Ti (tumour inducing) plasmid but no T-region, and at least one other plasmid having a T-region with incorporated therein foreign DNA but no vir-region, as well as to a Agrobacterium bacteria wherein at least one plasmid which has the vir-region of a Ti (tumour inducing) plasmid but no T-region and at least one other plasmid which has a wild type T-region with incorporated in it foreign DNA but no vir-region.
    Type: Grant
    Filed: February 23, 1984
    Date of Patent: July 10, 1990
    Inventors: Robbert A. Schilperoort, Andreas Hoekema, Paul J. J. Hooykaas