Patents by Inventor Paul J. Jackson
Paul J. Jackson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240077309Abstract: The present disclosure generally relates to displaying information related to a physical activity. In some embodiments, methods and user interfaces for managing the display of information related to a physical activity are described.Type: ApplicationFiled: January 12, 2023Publication date: March 7, 2024Inventors: Nicholas D. FELTON, James B. CARY, Edward CHAO, Kevin W. CHEN, Christopher P. FOSS, Eamon F. GILRAVI, Austen J. GREEN, Bradley W. GRIFFIN, Anders K. HAGLUNDS, Lori HYLAN-CHO, Stephen P. JACKSON, Matthew S. KOONCE, Paul T. NIXON, Robert M. PEARSON
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Publication number: 20240075895Abstract: Embodiments are disclosed for crash detection on one or more mobile devices (e.g., smartwatch and/or smartphone). In some embodiments, a method comprises: detecting, with at least one processor, a crash event on a crash device; extracting, with the at least one processor, multimodal features from sensor data generated by multiple sensing modalities of the crash device; computing, with the at least one processor, a plurality of crash decisions based on a plurality of machine learning models applied to the multimodal features; and determining, with the at least one processor, that a severe vehicle crash has occurred involving the crash device based on the plurality of crash decisions and a severity model.Type: ApplicationFiled: September 6, 2023Publication date: March 7, 2024Inventors: Vinay R. Majjigi, Sriram Venkateswaran, Aniket Aranake, Tejal Bhamre, Alexandru Popovici, Parisa Dehleh Hossein Zadeh, Yann Jerome Julien Renard, Yi Wen Liao, Stephen P. Jackson, Rebecca L. Clarkson, Henry Choi, Paul D. Bryan, Mrinal Agarwal, Ethan Goolish, Richard G. Liu, Omar Aziz, Alvaro J. Melendez Hasbun, David Ojeda Avellaneda, Sunny Kai Pang Chow, Pedro O. Varangot, Tianye Sun, Karthik Jayaraman Raghuram, Hung A. Pham
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Patent number: 11918582Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.Type: GrantFiled: March 14, 2022Date of Patent: March 5, 2024Assignee: RAPT Therapeutics, Inc.Inventors: Cyril Bucher, Adrian Dukes, Blanca Gomez, Hannah Haley, Dennis Hu, Jeffrey J. Jackson, Michelle Yoo Min Ko, Paul Leger, Anqi Ma, Andrew A. Ng, Daniel Poon, Omar Robles, Anton Shakhmin, Grant Shibuya, Parcharee Tivitmahaisoon, Vi-Anh Vu, David J. Wustrow, Mikhail Zibinsky
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Publication number: 20200400521Abstract: Targeted antimicrobials are described and related, compositions, methods and systems.Type: ApplicationFiled: May 21, 2020Publication date: December 24, 2020Inventors: Paul J. JACKSON, Brian E. SOUZA, Feliza A. BOURGUET, Matthew A. COLEMAN
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Patent number: 10688163Abstract: Targeted antimicrobials are described and related, compositions, methods and systems.Type: GrantFiled: August 11, 2014Date of Patent: June 23, 2020Assignee: Lawrence Livermore National Security, LLCInventors: Paul J. Jackson, Brian E. Souza, Feliza A. Bourguet, Matthew A. Coleman
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Publication number: 20140369990Abstract: Targeted antimicrobials are described and related, compositions, methods and systems.Type: ApplicationFiled: August 11, 2014Publication date: December 18, 2014Inventors: Paul J. JACKSON, Brian E. SOUZA, Feliza A. BOURGUET, Matthew A. COLEMAN
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Patent number: 8821860Abstract: Targeted antimicrobials are described and related, compositions, methods and systems.Type: GrantFiled: August 6, 2010Date of Patent: September 2, 2014Assignee: Lawrence Livermore National Security, LLCInventors: Paul J. Jackson, Brian E. Souza, Feliza A. Bourguet, Matthew A. Coleman
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Publication number: 20040014707Abstract: The cloning, expression and purification of a 32 kDa B. anthracis PA fragment (PA32) is described. This fragment has been expressed as a fusion construct to stabilized green fluorescent protein (EGFP-PA32). Both proteins bind to specific cell surface receptors. To confirm binding specificity, non-fluorescent PA83 or PA32 was used to competitively inhibit fluorescent EGFP-PA32 binding to cell receptors. The high intracellular expression levels and ease of purification make this recombinant protein an attractive vaccine candidate or therapeutic treatment for anthrax poisoning. Antibody fragments were isolated from a naive single-chain Fv (scFv) library biopanned against PA83. Four scFv proteins were found to bind to PA83, the best one exhibiting a 10 nM Kd. Two scFv proteins, scFv #1 and scFv #4, had similar affinities for PA32 and PA83, confirming the recombinant fragment was folded correctly.Type: ApplicationFiled: February 27, 2003Publication date: January 22, 2004Inventors: Nick M. Cirino, Paul J. Jackson, Bruce E. Lehnert
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Publication number: 20020055628Abstract: Bacillus anthracis is one the most molecularly homogeneous pathogens described, which makes strain discrimination particularly difficult. The present invention includes a molecular-typing method based upon rapidly evolving variable number tandem repeat (VNTR) loci. Multiple-locus VNTR analysis (MLVA) combines the information from multiple alleles at several marker loci. PCR amplification products from eight VNTR regions are detected and sized using fluorescently labeled primers. Five of these eight loci were discovered by characterization of AFLP markers (vrrC1, vrrC2, vrrB1, vrrB2 and CG3); two were discovered from complete plasmid nucleotide sequences (pXO1-aat, pXO2-at); and, one was previously known (vrrA). 425 isolates were characterized to identify 89 distinct genotypes. VNTR markers frequently had multiple alleles (from 2 to 8) and diversity (D) values between 0.3 and 0.8. UPGMA cluster analysis identified six genetically distinct groups that appear to represent genetic clones.Type: ApplicationFiled: April 26, 2001Publication date: May 9, 2002Inventors: Paul S. Keim, Paul J. Jackson
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Patent number: 6329156Abstract: The protective antigen (PA) of Bacillus anthracis is integral to the mechanism of anthrax poisoning. The cloning, expression and purification of a 32 kDa B. anthracis PA fragment (PA32) is described. This fragment has also been expressed as a fusion construct to stabilized green fluorescent protein (EGFP-PA32). Both proteins were capable of binding to specific cell surface receptors as determined by fluorescent microscopy and a flow cytometric assay. To confirm binding specificity in the flow cytometric assay, non-fluorescent PA83 or PA32 was used to competitively inhibit fluorescent EGFP-PA32 binding to cell receptors. This assay can be employed as a rapid screen for compounds which disrupts binding of PA to cells. Additionally, the high intracellular expression levels and ease of purification make this recombinant protein an attractive vaccine candidate or therapeutic treatment for anthrax poisoning.Type: GrantFiled: March 22, 1999Date of Patent: December 11, 2001Assignee: The Regents of the University of CaliforniaInventors: Nick M. Cirino, Paul J. Jackson, Bruce E. Lehnert
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Patent number: 5296146Abstract: The use of plant suspension cultures to remove ionic metallic species and TNT-based explosives and their oxidation products from aqueous solution is described. Several plant strains were investigated including D. innoxia, Citrus citrus, and Black Mexican Sweet Corn. All showed significant ability to remove metal ions. Ions removed to sub-ppm levels include barium, iron, and plutonium. D. innoxia cells growing in media containing weapons effluent contaminated with Ba.sup.2+ also remove TNT, other explosives and oxidation products thereof from solution. The use of dead, dehydrated cells was also found to be of use in treating waste directly.Type: GrantFiled: June 8, 1992Date of Patent: March 22, 1994Assignees: The Regents of the University of CA, Los Alamos National LaboratoryInventors: Paul J. Jackson, Agapito P. Torres, deceased, Emmanuel Delhaize
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Patent number: 5120441Abstract: The use of plant suspension cultures to remove ionic metallic species and TNT-based explosives and their oxidation products from aqueous solution is described. Several plant strains were investigated including D. innoxia, Citrus citrus, and Black Mexican Sweet Corn. All showed significant ability to remove metal ions. Ions removed to sub-ppm levels include barium, iron, and plutonium. D. innoxia cells growing in media containing weapons effluent contaminated with Ba.sup.2+ also remove TNT, other explosives and oxidation products thereof from solution. The use of dead, dehydrated cells were also found to be of use in treating waste directly.Type: GrantFiled: May 30, 1990Date of Patent: June 9, 1992Assignee: The Regents of the University of CaliforniaInventors: Paul J. Jackson, Agapito P. Torres, deceased, Emmanuel Delhaize
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Patent number: 5089470Abstract: A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly (.gamma.-glutamylcysteinyl)glycines, is immobilized on an inert material in particulate form. Upon contact with an aqueous solution containing heavy metals, the polypeptides sequester the metals, removing them from the solution. There is selectivity of poly (.gamma.-glutamylcysteinyl)glycines having a particular number of monomer repeat units for particular metals. The polypeptides are easily regenerated by contact with a small amount of an organic acid, so that they can be used again to remove heavy metals from solution. This also results in the removal of the metals from the column in a concentrated form.Type: GrantFiled: December 18, 1989Date of Patent: February 18, 1992Assignee: The United State of America as represented by the United States Department of EnergyInventors: Paul J. Jackson, Emmanuel Delhaize, Nigel J. Robinson, Clifford J. Unkefer, Clement Furlong
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Patent number: 4969995Abstract: A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly (.gamma.-glutamylcysteinyl)glycines, is immobilized on an inert material in particulate form. Upon contact with an aqueous solution containing heavy metals, the polypeptides sequester the metals, removing them from the solution. There is selectivity of poly (.gamma.-glutamylcysteinyl)glycines having a particular number of monomer repeat unit for particular metals. The polypeptides are easily regenerated by contact with a small amount of an organic acid, so that they can be used again to remove heayv metals from solution. This also results in the removal of the metals from the column in a concentrated form.Type: GrantFiled: December 18, 1989Date of Patent: November 13, 1990Assignee: The United States of America as represented by the United States Department of EnergyInventors: Paul J. Jackson, Emmanuel Delhaize, Nigel J. Robinson, Clifford J. Unkefer, Clement Furlong
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Patent number: 4909944Abstract: A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly (.gamma.-glutamylcysteinyl)glycines, is immobilized on an inert material in particulate form. Upon contact with an aqueous solution containing heavy metals, the polypeptides sequester the metals, removing them from the solution. There is selectivity of poly (.gamma.-glutamylcysteinyl)glycines having a particular number of monomer repeat units for particular metals. The polypeptides are easily regenerated by contact with a small amount of an organic acid, so that they can be used again to remove heavy metals from solution. This also results in the removal of the metals from the column in a concentrated form.Type: GrantFiled: August 26, 1988Date of Patent: March 20, 1990Assignee: The United States of America as represented by the United States Department of EnergyInventors: Paul J. Jackson, Emmanuel Delhaize, Nigel J. Robinson, Clifford J. Unkefer, Clement Furlong