Patents by Inventor Paul J. Maes

Paul J. Maes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified release formulations of at least one form of tramadol
    Patent number: 8158147
    Abstract: The present invention relates to a modified release composition of at least one form of tramadol which is a delayed and extended release composition for oral administration suitable for once daily dosing. That composition comprises a core comprising at least one form of tramadol selected from the group consisting of tramadol, racemic mixtures thereof, enantiomers thereof, pharmaceutically acceptable salts thereof, and combinations thereof in combination with a pharmaceutically acceptable excipient. That composition further comprises a modified release coating which substantially surrounds said core. The compositions of the invention provide delayed and extended release of said at least one form of tramadol such that the mean plasma concentration of the at least one form of tramadol reaches a therapeutically effective level at a time which is after at least about 3 hours after first administration.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: April 17, 2012
    Assignee: Valeant International (Barbados) SRL
    Inventors: Pawan Seth, Paul J. Maes
  • Modified release compositions of at least one form of tramadol
    Patent number: 8128957
    Abstract: The present invention relates to a modified release composition of at least one form of tramadol which is a delayed and extended release composition for oral administration suitable for once daily dosing. That composition comprises a core comprising at least one form of tramadol selected from the group consisting of tramadol, racemic mixtures thereof, enantiomers thereof, pharmaceutically acceptable salts thereof, and combinations thereof in combination with a pharmaceutically acceptable excipient. That composition further comprises a modified release coating which substantially surrounds said core. The compositions of the invention provide delayed and extended release of said at least one form of tramadol such that the mean plasma concentration of the at least one form of tramadol reaches a therapeutically effective level at a time which is after at least about 3 hours after first administration.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: March 6, 2012
    Assignee: Valeant International (Barbados) SRL
    Inventors: Pawan Seth, Paul J. Maes
  • Pharmaceutical method and preparation containing indomethacin
    Patent number: 5036100
    Abstract: This invention relates to a liquid pharmaceutical preparation for topical use on the skin of patients, said preparation containing indomethacin as active ingredient and dimethylisosorbide and isopropanol as excipients.The preparation according to the invention allows an easy and precise local administration by external application on the skin of a solution of indomethacin in the excipients.
    Type: Grant
    Filed: October 5, 1989
    Date of Patent: July 30, 1991
    Assignee: Pharlyse S.A. Societe Anonyme
    Inventors: Arthur M. Deboeck, Philippe R. Baudier, Jacques J. Fossion, Paul J. Maes