Patents by Inventor Paul J. Mihalko

Paul J. Mihalko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating respiratory disorders associated with pulmonary elastic fiber injury
    Publication number: 20020086852
    Abstract: The present invention relates generally to the field of respiratory therapeutics, and in particular to the treatment of disorders of the lung matrix caused by damage to the elastic fibers of the lung matrix. More specifically, methods and materials are disclosed for the delivery to the lungs of polysaccharides, derivatives thereof and/or drug conjugates, used in the treatment and/or prevention of pulmonary disorders.
    Type: Application
    Filed: May 23, 2001
    Publication date: July 4, 2002
    Inventors: Jerome O. Cantor, Jing-wen Kuo, Paul J. Mihalko, Dan Sachs, Gerard Turino
  • Liposome/bronchodilator method & System
    Patent number: 5340587
    Abstract: A method and system for treating bronchial constriction. The system includes a liposome composition containing a .beta..sub.2 -adrenoreceptor agonist in a liposome-entrapped form, and a device for aerosolizing a metered quantity of the composition. The drug in liposome aerosol form is substantially more effective in bronchodilation, over a substantially longer time, than the same amount of drug in free-drug aerosol form.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: August 23, 1994
    Assignee: Liposome Technology, Inc.
    Inventors: Paul J. Mihalko, Robert M. Abra, Ramachandran Radhakrishnan
  • Corticosteroid inhalation treatment method
    Patent number: 5192528
    Abstract: A method for delivering a therapeutic dosage of corticosteroid drug to the lungs, for treating a lung condition or disease. An aqueous suspension of sized liposomes containing the drug in liposome-entrapped form is aerosolized under conditions which produce aerosol particle sizes favoring particle deposition in a selected region of the respiratory tract, and the aerosol is administered in an amount which delivers the thereapeutic dosage level to the selected lung region.
    Type: Grant
    Filed: December 1, 1989
    Date of Patent: March 9, 1993
    Assignee: Liposome Technology, Inc.
    Inventors: Ramachandran Radhakrishnan, Paul J. Mihalko, Robert M. Abra
  • Method and apparatus for administering dehydrated liposomes by inhalation
    Patent number: 4895719
    Abstract: A system and method for administering a drug, at a selected dose, via the respiratory tract. Spray-dried liposome particles containing the selected dose of the entrapped drug are released into the air in aerosolized form, either by entrainment in an air or propellant stream, or by release from a pressurized can containing a suspension of the liposomes in a fluorchlorocarbon solvent.
    Type: Grant
    Filed: March 6, 1987
    Date of Patent: January 23, 1990
    Assignee: Liposome Technology, Inc.
    Inventors: Ramachandran Radhakrishnan, Paul J. Mihalko, Robert M. Abra