Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: An operable panel for an appliance includes a metallic outer wrapper having a perimetrical wrapper edge that partially defines a perimetrical breaker channel, an inner liner and a plurality of corner brackets disposed proximate the perimetrical wrapper edge. Each corner bracket cooperates with the perimetrical wrapper edge to fully define the perimetrical breaker channel. A trim breaker is adhered to the metallic outer wrapper and the corner brackets at the perimetrical breaker channel and having a liner channel that receives a portion of the inner liner. The trim breaker extends between the inner liner and the outer wrapper. An insulation material is disposed within an insulating cavity defined between the inner liner and the outer wrapper.

Abstract: A system may generate a waveform signal indicative of a biometric parameter of a target subject based on motion data associated with the target subject. The motion data may be provided by a depth sensing device and be substantially free of image data. The system may set a threshold condition based on one or more characteristics of the waveform signal. The system may output a control signal to a stimulation device based on the waveform signal satisfying the threshold condition.

Abstract: An operable panel for an appliance includes a metallic outer wrapper having a perimetrical wrapper edge that partially defines a perimetrical breaker channel, an inner liner and a plurality of corner brackets disposed proximate the perimetrical wrapper edge. Each corner bracket cooperates with the perimetrical wrapper edge to fully define the perimetrical breaker channel. A trim breaker is adhered to the metallic outer wrapper and the corner brackets at the perimetrical breaker channel and having a liner channel that receives a portion of the inner liner. The trim breaker extends between the inner liner and the outer wrapper. An insulation material is disposed within an insulating cavity defined between the inner liner and the outer wrapper.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed. An inner shroud damper for a gas turbine engine includes: at least one carrier including a joint to couple to an inner shroud, the at least one carrier having a first side and a second side, and at least one mass damper coupled to the at least one carrier.

Abstract: A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.

Abstract: A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.

Abstract: An authentication server may not support all types of user credentials. For example, an on-premise authentication server may support credentials based on user secrets (i.e. username and password) and certificate-based credentials, but not hardware-key based credentials. A client device may use an un-supported type of credential to access resources managed by the on-premise authentication server by authenticating with a web-based authentication server. The web-based authentication server may support any type of credential, and the supported types of credentials may change over time. The web-based authentication server returns an authenticated user token indicating the user has been authenticated, but without authorizing access to any resources. The client device uses the on-premise authentication server to exchange the authenticated user token for an authorized user token. The client device then uses the authorized user token to access resources on the on-premise network.

Abstract: An authentication server may not support all types of user credentials. For example, an on-premise authentication server may support credentials based on user secrets (i.e. username and password) and certificate-based credentials, but not hardware-key based credentials. A client device may use an un-supported type of credential to access resources managed by the on-premise authentication server by authenticating with a web-based authentication server. The web-based authentication server may support any type of credential, and the supported types of credentials may change over time. The web-based authentication server returns an authenticated user token indicating the user has been authenticated, but without authorizing access to any resources. The client device uses the on-premise authentication server to exchange the authenticated user token for an authorized user token. The client device then uses the authorized user token to access resources on the on-premise network.

Abstract: A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.

Abstract: A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.

Abstract: A fluid path set for a fluid delivery system includes a tube coil that is designed to optimally position one or more volumes of a pharmaceutical within an ionization chamber to measure and prepare a pharmaceutical dose for administration to a patient. Methods for priming at least a portion of the fluid path set include placing a tubing section of the fluid path set in fluid connection with a source of a radiopharmaceutical, and placing the tube coil within a dose calibrator of the fluid delivery system. A volume of the radiopharmaceutical may be pumped through the tube coil, the tubing section, and an additional tubing section, and the dose calibrator may be monitored to determine if a measured activity level is substantially equal to or above a predetermined activity level, and if so, it may be concluded that the tubing section of the fluid path set has been primed.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a push member having a proximal portion with a proximal stiffness, a distal portion with a distal stiffness different from the proximal stiffness, and a transition portion disposed between the proximal portion and the distal portion. The transition portion may provide a smooth transition between the proximal stiffness and the distal stiffness. The push member may have a first outer diameter. A distal tubular member may be attached to the push member. The distal tubular member may have a second outer diameter larger than the first outer diameter.

Abstract: The disclosure pertains to debris diverters for use within the aorta and methods of diverting or redirecting emboli and other debris away from the carotid arteries to prevent cerebral embolization. The disclosure includes aortic diverters positionable in the ascending aorta in order to divert embolic material of all sizes away from the carotid arteries, thereby washing emboli downstream into the thoracic and peripheral vasculature. The debris diverters of the disclosure are adapted to be placed in the ascending and transverse aorta via the left subclavian artery in order to divert embolic material away from the carotid arteries and methods of use therefor.

Abstract: The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.

Abstract: A fluid path set for a fluid delivery system includes a tube coil that is designed to optimally position one or more volumes of a pharmaceutical within an ionization chamber to optimally measure and prepare a pharmaceutical dose for administration to a patient. The tube coil may be maintained in a desired dimensional geometry by means of a core structure around which the tube coil is positioned.

Abstract: A client can communicate with a middle tier, which can then, in turn, communicate with a back end tier to access information and resources on behalf of the client within the context of a system that can scale well. Each individual back end can establish a policy that defines which computing device can delegate to that back end. That policy can be enforced by a domain controller within the same administrative domain as the particular back end. When a middle tier requests to delegate to a back end, the domain controller to which that request was directed can either apply the policy, or, if the domain controller is in a different domain than the targeted back end, it can direct the middle tier to a domain controller in a different domain and can sign relevant information that the middle tier can utilize when communicating with that different domain controller.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a push member having a proximal portion with a proximal stiffness, a distal portion with a distal stiffness different from the proximal stiffness, and a transition portion disposed between the proximal portion and the distal portion. The transition portion may provide a smooth transition between the proximal stiffness and the distal stiffness. The push member may have a first outer diameter. A distal tubular member may be attached to the push member. The distal tubular member may have a second outer diameter larger than the first outer diameter.

Abstract: A fluid path set for a fluid delivery system includes a tube coil that is designed to optimally position one or more volumes of a pharmaceutical within an ionization chamber to measure and prepare a pharmaceutical dose for administration to a patient. The fluid path set includes a medical fluid component having a first tubing section for connection to a source of a medical fluid, a pharmaceutical component having a second tubing section for connection to a source of a pharmaceutical, and a coil assembly which includes the tube coil. The tube coil may be maintained in a desired dimensional geometry by means of a core structure around which the tube coil is positioned.