Patents by Inventor Paul J. Muchowski

Paul J. Muchowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying agents that diminish cellular toxicity associated with an ?-synuclein polypeptide of parkinson's disease in yeast
    Patent number: 8735072
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: May 27, 2014
    Assignees: Whitehead Institute for Biomedical Research, University of Washington
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Small molecule inhibitors of kynurenine-3-monooxygenase
    Patent number: 8710237
    Abstract: The present invention relates to compounds of formula Ia or Ib below and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: April 29, 2014
    Assignees: The J. David Gladstone Institute, University of Maryland, Baltimore
    Inventors: Paul J. Muchowski, Joseph M. Muchowski, Robert Schwarcz, Paolo Guidetti
  • Small molecule inhibitors of kynurenine-3-monooxygenase
    Patent number: 8466182
    Abstract: The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: June 18, 2013
    Assignees: The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone, University of Maryland, Baltimore
    Inventors: Paul J. Muchowski, Joseph M. Muchowski, Robert Schwarcz, Paolo Guidetti
  • METHODS OF IDENTIFYING LEAD COMPOUNDS THAT MODULATE TOXICITY OF NEUROTOXIC POLYPEPTIDES
    Publication number: 20130084596
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Application
    Filed: March 13, 2012
    Publication date: April 4, 2013
    Applicants: UNIVERSITY OF WASHINGTON, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Methods of identifying agents that diminish cellular toxicity associated with an ?-synuclein polypeptide of Parkinson's disease in yeast
    Patent number: 8133679
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: March 13, 2012
    Assignees: Whitehead Institute for Biomedical Research, University of Washington
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • SMALL MOLECULE INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
    Publication number: 20120046324
    Abstract: The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof.
    Type: Application
    Filed: November 2, 2011
    Publication date: February 23, 2012
    Inventors: Paul J. Muchowski, Joseph M. Muchowski, Robert Schwarcz, Paolo Guidetti
  • SMALL MOLECULE INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
    Publication number: 20120022052
    Abstract: The present invention relates to compounds of formula Ia or Ib below and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 26, 2012
    Inventors: Paul J. Muchowski, Joseph M. Muchowski, Robert Schwarcz, Paolo Guidetti
  • Small molecule inhibitors of kynurenine-3-monooxygenase
    Patent number: 8071631
    Abstract: The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof:
    Type: Grant
    Filed: August 16, 2007
    Date of Patent: December 6, 2011
    Assignees: The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone, University Of Maryland, Baltimore
    Inventors: Paul J. Muchowski, Joseph M. Muchowski, Robert Schwarcz, Paolo Guidetti
  • Small molecule inhibitors of kynurenine-3-monooxygenase
    Patent number: 7994338
    Abstract: The present invention relates to compounds of formula Ia or Ib below and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.
    Type: Grant
    Filed: August 16, 2007
    Date of Patent: August 9, 2011
    Assignees: The J. David Gladstone Institutes, University Of Maryland, Baltimore
    Inventors: Paul J. Muchowski, Joseph M. Muchowski, Robert Schwarcz, Paolo Guidetti
  • Identifying agents for decreasing cellular toxicity associated with huntingin polypeptide
    Patent number: 7618793
    Abstract: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: November 17, 2009
    Assignee: The Regents of the University of Washington
    Inventors: Paul J. Muchowski, Flaviano Giorgini
  • Drug targets for the treatment of neurodegenerative disorders
    Patent number: 7504227
    Abstract: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: March 17, 2009
    Assignee: University of washington
    Inventors: Paul J. Muchowski, Vicente E. Sancenon Galarza
  • METHODS OF IDENTIFYING LEAD COMPOUNDS THAT MODULATE TOXICITY OF NEUROTOXIC POLYPEPTIDES
    Publication number: 20090068111
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Application
    Filed: November 17, 2008
    Publication date: March 12, 2009
    Applicants: UNIVERSITY OF WASHINGTON, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Methods of identifying agents that diminish cellular toxicity associated with an ?-synuclein polypeptide of Parkinson's disease in yeast
    Patent number: 7452670
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: November 18, 2008
    Assignees: University of Washington, Whitehead Institute for Biomedical Research
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Non-invasive methods and related compositions for identifying compounds that modify in vivo aggregations of disease-related polypeptides
    Publication number: 20080168569
    Abstract: Embodiments of the present invention are directed to various high-throughput methods for identifying compounds that are useful for the treatment of various neurodegenerative diseases, including the Huntington's Disease (HD), Parkinson's Disease (PD), Alzheimer's Disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Methods and compositions of the present invention enable the exogenous expression of one or more neurodegenerative-disease-related polypeptide variants within the ocular lens of an animal host. The formation of aggregates containing neurodegenerative-disease-related polypeptide variants increases the opacity of the lens, in a manner similar to the development of age-onset cataracts. The effect of a test compound in decreasing aggregate formation and/or destabilizing aggregates that contain neurodegenerative-disease-related polypeptide variants can be visually monitored and quantified in living animal hosts by employing conventional cataract-detecting instrumentation and related methods.
    Type: Application
    Filed: August 13, 2004
    Publication date: July 10, 2008
    Inventors: Paul J. Muchowski, John I. Clark