Abstract: A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, wherein, R, R1, R2, R3 and X are as defined herein.

Abstract: A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, wherein, R, R1, R2, R3 and X are as defined herein.

Abstract: The invention relates to heterocyclic substituted urea derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders.

Abstract: In a spray nozzle (10), a carrier (12) defines a spray aperture (20), a groove (30) surrounding the spray aperture for receiving an o-ring (32), a first locating bore (26) for slidably receiving an orifice plate (14) seated against the o-ring (32) and for aligning the orifice plate with the spray aperture, and a second locating bore (28) for slidably receiving a swirl unit and aligning the swirl unit (16) with the orifice plate and spray aperture. The swirl unit (16) defines on its peripheral surface a recessed flat (58) forming a fluid passageway between the swirl unit and carrier. The swirl unit (16) includes a swirl chamber (60) defined by a curvilinear surface (62) formed within the swirl unit, and an inlet port (64) formed in fluid communication between the swirl chamber and fluid passageway. The nozzle body (18) is threadedly received within the carrier (12) behind the swirl unit (16) to axially press the swirl unit, and in turn press the orifice plate (14) against the adjacent surface of the carrier.

Abstract: In a spray nozzle (10), a carrier (12) defines a spray aperture (20), a groove (30) surrounding the spray aperture for receiving an o-ring (32), a first locating bore (26) for slidably receiving an orifice plate (14) seated against the o-ring (32) and for aligning the orifice plate with the spray aperture, and a second locating bore (28) for slidably receiving a swirl unit and aligning the swirl unit (16) with the orifice plate and spray aperture. The swirl unit (16) defines on its peripheral surface a recessed flat (58) forming a fluid passageway between the swirl unit and carrier. The swirl unit (16) includes a swirl chamber (60) defined by a curvilinear surface (62) formed within the swirl unit, and an inlet port (64) formed in fluid communication between the swirl chamber and fluid passageway. The nozzle body (18) is threadedly received within the carrier (12) behind the swirl unit (16) to axially press the swirl unit, and in turn press the orifice plate (14) against the adjacent surface of the carrier.