Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.

Abstract: A replaceable fluid restriction mechanism includes: an aperture residing adjacent to a fluid pathway connection and configured to permit flow of a drug fluid through the aperture when the fluid pathway connection is open; an entry point of a fluid channel configured such that the flow of drug fluid can travel through aperture to the entry point and through the fluid channel to an exit point; and an outlet aperture of a port through which the flow of drug fluid may travel after exiting the exit point, wherein a fluid conduit is connected to the fluid restriction mechanism at the outlet aperture. A configurable fluid restriction mechanism includes a plurality of fluid channels, selectable to align with the entry point and an exit point of the fluid restriction mechanism.

Abstract: A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Abstract: A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Abstract: A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Abstract: The present invention describes a method and an apparatus for plasma coating the inside surface of a container to provide an effective barrier against gas transmission. The method provides a way to deposit rapidly and uniformly very thin and nearly defect-free layers of polyorganosiloxane and silicon oxide on the inner surface of a container to achieve more than an order of magnitude increase in barrier properties.

Abstract: A barrier to diffusion of gas through polymers by means of plasma generated coating on polymeric substrates. The coating is suitable for application on planar polymeric substrates such a sheet or film. The coating is suitable for application on three-dimensional polymeric substrates, such as polymeric containers, or bottles.

Abstract: A barrier to diffusion of gas through polymers by means of plasma generated coating on polymeric substrates. The coating is suitable for application on planar polymeric substrates such as sheet or film. The coating is suitable for application on three-dimensional polymeric substrates, such as polymeric containers, or bottles.

Abstract: A self-cleaning automotive head lamp, wherein the inner surface of the lens has applied to it an amphiphilic coating containing a photocatalyst.

Abstract: The present invention is a covered microchannel comprising: a) a substrate; b) an etched material adhered to the substrate; and c) a silicon-carbon material adhered to the etched material in such a manner to form a covered microchannel; wherein the silicon-carbon material comprises SiO.sub.1.8-2.4 C.sub.0.3-1.0 and H.sub.0.7-4.0 containing at least one of the following functional groups:--Si--O--Si--, --Si--CH.sub.2 --, --Si--H, or --Si--OH.The covered microchannel can be prepared by the steps of: a) coating a filler material onto a substrate having a groove, wherein the filler material covering the substrate fills the groove; b) removing filler material from the substrate but not from the groove; c) coating the substrate and the filler with an adhering, formable, capping material; and d) removing the filler from the groove. An etched laminate can also be used to prepare the covered microchannel.

Abstract: The present invention is a laminate which comprises:a) a plastic substrate having a surface;b) an adhesion promoter layer which is a first plasma polymerized organosilicon compound deposited on the surface of the substrate in the substantial absence of oxygen; andc) a protective coating layer which is a second plasma polymerized organosilicon compound deposited on the surface of the adhesion layer at a power density from about 10.sup.6 J/kg to about 10.sup.8 J/kg, and in the presence of a sufficient stoichiometric excess of oxygen to form a silicon polymer of SiO.sub.1.8-2.4 C.sub.0.3-1.0 and H.sub.0.7-4.0.The coating layer provides abrasion and solvent resistance for the substrate, and the adhesion promoter prevents the coating layer from peeling off the substrate. The coated plastic substrate can be used in liquid crystal display devices as an alternative to glass.

Abstract: A reversed permeation membrane assembly and method for collecting one or more compounds of interest from a sample solution. The membrane assembly includes a semi-permeable membrane of predetermined thickness and length, and having inner and outer surfaces. The membrane is attached adjacent its outer surface to a substantially rigid membrane support, and a non-porous barrier contacts the outer surface of the membrane to prevent permeation of compounds beyond the outer surface in use. In a preferred embodiment, the semi-permeable membrane assumes a substantially tubular conformation through which sample solution may be passed. The membrane support also preferably features a tubular conformation within which the semi-permeable membrane is mounted. Because of its unique structure and improved efficiency, the assembly of the present invention may be incorporated for in-line use with liquid and gas chromatography devices and GC/MS units.

Abstract: This disclosure relates to a new organic base, asbestos-free, asphalt-aluminum coating composition for use on roofs and the like. By the use of a gelling agent in place of asbestos fiber, a product with superior reflectivity is obtained which contains less aluminum than typical asbestos-containing coatings. In addition, since no water is used in the formulation of the composition, the possibility of producing such undesirable by-products as hydrogen gas or aluminum hydroxide is virtually eliminated.